2020
Individual‐ and hospital‐level correlates of red blood cell, platelet, and plasma transfusions among hospitalized children and neonates: a nationally representative study in the United States
Goel R, Josephson CD, Patel EU, Petersen MR, Packman Z, Gehrie E, Bloch EM, Lokhandwala P, Ness PM, Katz L, Nellis M, Karam O, Tobian AAR. Individual‐ and hospital‐level correlates of red blood cell, platelet, and plasma transfusions among hospitalized children and neonates: a nationally representative study in the United States. Transfusion 2020, 60: 1700-1712. PMID: 32589286, PMCID: PMC7951993, DOI: 10.1111/trf.15855.Peer-Reviewed Original ResearchConceptsAdjusted odds ratioRed blood cellsRBC transfusionPlatelet transfusionsPlasma transfusionAge groupsBlood cellsElective admission statusProportion of neonatesMultivariable logistic regressionOlder age groupsTotal hospitalizationsPrimary outcomeSecondary outcomesHospitalized neonatesNonwhite raceHospitalized childrenFemale sexOverall prevalenceOdds ratioHospital birthsPediatric dischargesTransfusion proceduresTransfusionHigh risk
2019
Anemia at Discharge From the PICU: A Bicenter Descriptive Study.
Demaret P, Valla FV, Behal H, Mimouni Y, Baudelet JB, Karam O, Recher M, Duhamel A, Tucci M, Javouhey E, Leteurtre S. Anemia at Discharge From the PICU: A Bicenter Descriptive Study. Pediatric Critical Care Medicine 2019, 20: e400-e409. PMID: 31246740, DOI: 10.1097/pcc.0000000000002015.Peer-Reviewed Original ResearchConceptsPediatric critical illnessPICU admissionPICU dischargeRisk of anemiaCritical illnessRisk markersHigher C-reactive protein levelsInotropic/vasopressor supportC-reactive protein levelsWorld Health Organization criteriaMedian hemoglobin levelRetrospective cohort studyElectronic medical recordsVasopressor supportPlasma transfusionCohort studyCreatinine levelsMultivariate adjustmentAnemic childrenHemoglobin levelsMechanical ventilationAnemia statusOrganization criteriaMedical recordsIll childrenInternational Study of the Epidemiology of Platelet Transfusions in Critically Ill Children With an Underlying Oncologic Diagnosis.
Nellis ME, Goel R, Karam O, Cushing MM, Davis PJ, Steiner ME, Tucci M, Stanworth SJ, Spinella PC. International Study of the Epidemiology of Platelet Transfusions in Critically Ill Children With an Underlying Oncologic Diagnosis. Pediatric Critical Care Medicine 2019, 20: e342-e351. PMID: 31107379, DOI: 10.1097/pcc.0000000000001987.Peer-Reviewed Original ResearchConceptsPlatelet transfusionsOncologic diagnosisIll childrenCurrent recommendationsHematopoietic stem cell transplantationCritically Ill ChildrenExtracorporeal life supportStem cell transplantationTotal platelet countMechanical ventilationPlatelet countAppropriate indicationsCell transplantationPediatric intensivistsSubgroup analysisObservational studyPlatelet functionTransfusionParent studyTherapeutic transfusionTotal plateletsLife supportDiagnosisVulnerable populationsSignificant differences
2016
Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) in children and adults
Gebistorf F, Karam O, Wetterslev J, Afshari A. Inhaled nitric oxide for acute respiratory distress syndrome (ARDS) in children and adults. Cochrane Database Of Systematic Reviews 2016, 2018: cd002787. PMID: 27347773, PMCID: PMC6464789, DOI: 10.1002/14651858.cd002787.pub3.Peer-Reviewed Original ResearchConceptsAcute respiratory distress syndromeAcute hypoxaemic respiratory failureTrial sequential analysisEffects of iNORespiratory distress syndromeINO groupControl groupDistress syndromeNitric oxideRisk ratioSecondary objectiveHypoxaemic respiratory failureTrial methodological componentsVentilator-free daysCochrane Central RegisterPrimary outcome measureEffect of administrationLength of stayRisk of biasConfidence intervalsAllied Health LiteratureSearch of MEDLINELevel of evidenceEffects of interventionsNitric oxide results
2015
Clinical Outcomes Associated With RBC Transfusions in Critically Ill Children
Demaret P, Tucci M, Karam O, Trottier H, Ducruet T, Lacroix J. Clinical Outcomes Associated With RBC Transfusions in Critically Ill Children. Pediatric Critical Care Medicine 2015, 16: 505-514. PMID: 25905491, DOI: 10.1097/pcc.0000000000000423.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesChildChild, PreschoolCritical CareCritical IllnessErythrocyte TransfusionFemaleHumansInfantInfant, NewbornIntensive Care Units, PediatricLength of StayMaleMultiple Organ FailureOxygenPartial PressureProspective StudiesRenal Replacement TherapyRespiration, ArtificialTime FactorsTreatment OutcomeConceptsProgressive multiple organ dysfunction syndromeMultiple organ dysfunction syndromeFirst RBC transfusionOrgan dysfunction syndromeRBC transfusionIll childrenDysfunction syndromeRenal replacement therapyTertiary children's hospitalCritically Ill ChildrenProspective observational studyArterial partial pressurePICU lengthProlonged PICUPICU patientsMedical chartsClinical outcomesMechanical ventilationMultivariable analysisChildren's HospitalPotential confoundersReplacement therapyConsecutive admissionsPotential complicationsOdds ratio
2011
Red blood cell transfusion thresholds in pediatric patients with sepsis*
Karam O, Tucci M, Ducruet T, Hume HA, Lacroix J, Gauvin F. Red blood cell transfusion thresholds in pediatric patients with sepsis*. Pediatric Critical Care Medicine 2011, 12: 512-518. PMID: 21057356, DOI: 10.1097/pcc.0b013e3181fe344b.Peer-Reviewed Original ResearchConceptsRed blood cell transfusionBlood cell transfusionProgressive multiple organ dysfunction syndromeMultiple organ dysfunction syndromeOrgan dysfunction syndromeCell transfusionTransfusion thresholdDysfunction syndromeTransfusion strategySubgroup analysisIll childrenPediatric intensive care unit studyRed blood cell transfusion thresholdRestrictive red-cell transfusion strategyCritical care unit admissionRed-cell transfusion strategyIntensive care unit studiesPediatric critical care unitLiberal transfusion strategyRestrictive transfusion thresholdCare unit admissionSubgroup of patientsCritical care unitsTransfusion requirementsUnit admission