2023
The Effects of Expectation Setting and Bundle Consent on Acute Caregiver Stress in the PICU: A Randomized Controlled Trial
Goldstein G, Karam O, Miller Ferguson N. The Effects of Expectation Setting and Bundle Consent on Acute Caregiver Stress in the PICU: A Randomized Controlled Trial. Pediatric Critical Care Medicine 2023, 24: 692-700. PMID: 37125809, DOI: 10.1097/pcc.0000000000003265.Peer-Reviewed Original ResearchConceptsBundled consentSeverity of illnessParents' perceptionsParents/guardians of patientsParents' perceived severityNegative mental health consequencesMental health consequencesPercentage of parentsCaregiver stressPersonal vulnerabilityChild's illnessChild's admissionControl groupChild's conditionExperimental groupPatients admitted to PICUDemographic surveyHealth consequencesLife-threatening natureStress burdenExpectation settingDemographic variablesControl weekIllnessAdmitted to PICU
2021
Transfusion practices for pediatric oncology and hematopoietic stem cell transplantation patients: Data from the National Heart Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study‐III (REDS‐III)
Goel R, Nellis ME, Karam O, Hanson SJ, Tormey CA, Patel RM, Birch R, Sachais BS, Sola‐Visner M, Hauser RG, Luban NLC, Gottschall J, Josephson CD, Hendrickson JE, Karafin MS, Study‐IV‐Pediatric F. Transfusion practices for pediatric oncology and hematopoietic stem cell transplantation patients: Data from the National Heart Lung and Blood Institute Recipient Epidemiology and Donor Evaluation Study‐III (REDS‐III). Transfusion 2021, 61: 2589-2600. PMID: 34455598, DOI: 10.1111/trf.16626.Peer-Reviewed Original ResearchConceptsInternational normalized ratioBlood Institute Recipient EpidemiologyDonor Evaluation Study-IIINational Heart LungTransfusion practicePediatric oncologyRecipient EpidemiologyHSCT patientsPlasma transfusionRed blood cellsPlatelet countHeart LungHematopoietic stem cell transplantation patientsHematopoietic stem cell transplant patientsMedian international normalized ratioStem cell transplant patientsStem cell transplantation patientsLower INR valuesPre-transfusion HbMedian platelet countMulticenter retrospective studyCell transplant patientsCell transplantation patientsStudy IIIAcute myeloid leukemiaTransfusion practices in a large cohort of hospitalized children
Nellis ME, Goel R, Hendrickson JE, Birch R, Patel RM, Karafin MS, Hanson SJ, Sachais BS, Hauser RG, Luban NLC, Gottschall J, Sola‐Visner M, Josephson CD, Karam O, Study‐IV‐Pediatric F. Transfusion practices in a large cohort of hospitalized children. Transfusion 2021, 61: 2042-2053. PMID: 33973660, DOI: 10.1111/trf.16443.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlood Component TransfusionBlood TransfusionChildChild, PreschoolDatasets as TopicDiagnosis-Related GroupsFemaleHospital MortalityHospitals, CommunityHospitals, TeachingHumansInfantInfant, NewbornInpatientsMaleProcedures and Techniques UtilizationRetrospective StudiesUnited StatesConceptsRBC transfusionCardiopulmonary bypassTransfusion practiceHospitalized childrenInpatient encountersBlood componentsLarge cohortHospital settingBlood Institute Recipient EpidemiologyDonor Evaluation Study-IIIPatient blood management initiativesDiagnostic categoriesFrequency of transfusionInstitutional transfusion guidelinesCohort of patientsInternational normalized ratioPercent of encountersNational Heart LungPediatric hospital settingYears of ageSubset of childrenRecipient EpidemiologyTransfusion guidelinesRed blood cellsEntire cohort
2020
Effect of platelet storage duration on clinical outcomes and incremental platelet change in critically ill children
Nellis ME, Spinella PC, Tucci M, Stanworth SJ, Steiner ME, Cushing MM, Davis PJ, Karam O, The Pediatric Acute Lung Injury and Sepsis Investigators network P. Effect of platelet storage duration on clinical outcomes and incremental platelet change in critically ill children. Transfusion 2020, 60: 2849-2858. PMID: 32959409, PMCID: PMC8396066, DOI: 10.1111/trf.16094.Peer-Reviewed Original ResearchConceptsClinical outcomesIll childrenPLT transfusionsObservational point prevalence studyPediatric intensive care unitStorage ageSafety of plateletsFurther prospective evaluationPoint prevalence studyIntensive care unitImmune system dysfunctionFebrile transfusion reactionsDays of ageScreening weekCare unitProspective evaluationSystem dysfunctionTransfusion reactionsPlatelet changesTransfusionPLT countTransfusion efficacyAge groupsSecondary analysisSignificant associationPleural Effusions After Congenital Cardiac Surgery Requiring Readmission: A Systematic Review and Meta-analysis
Hughes A, Carter K, Cyrus J, Karam O. Pleural Effusions After Congenital Cardiac Surgery Requiring Readmission: A Systematic Review and Meta-analysis. Pediatric Cardiology 2020, 41: 1145-1152. PMID: 32424719, DOI: 10.1007/s00246-020-02365-4.Peer-Reviewed Original ResearchConceptsCongenital heart diseaseSingle-ventricle palliationPleural effusionRisk factorsPost-pericardiotomy syndromeImproved risk stratificationSingle ventricle physiologySubpopulation of patientsAdditional invasive proceduresRandom-effects modelFull-text articlesBiventricular physiologyHospital dischargeSurgical patientsCardiopulmonary bypassRisk stratificationPatient populationEarly recognitionHeart diseaseOverall prevalenceSurgical techniqueFallot patientsInvasive proceduresReadmissionPatientsPerioperative Transfusions and Venous Thromboembolism
Goel R, Josephson CD, Patel EU, Petersen MR, Makhani S, Frank SM, Ness PM, Bloch EM, Gehrie EA, Lokhandwala PM, Nellis MM, Karam O, Shaz BH, Patel RM, Tobian AAR. Perioperative Transfusions and Venous Thromboembolism. Pediatrics 2020, 145: e20192351. PMID: 32198293, PMCID: PMC7111487, DOI: 10.1542/peds.2019-2351.Peer-Reviewed Original ResearchConceptsPerioperative RBC transfusionPostoperative venous thromboembolismNational Surgical Quality Improvement ProjectVenous thromboembolismRBC transfusionRed blood cellsSurgeons National Surgical Quality Improvement ProjectDevelopment of VTESurgical Quality Improvement ProjectDay of surgeryMultivariable logistic regressionQuality improvement projectDose-dependent mannerPerioperative transfusionPostoperative transfusionTransfusion statusThird tertilePediatric patientsPostoperative developmentSecond tertileAnnual incidenceProspective studyTransfusion decisionsHospitalized childrenBody of evidencePediatric Plasma and Platelet Transfusions on Extracorporeal Membrane Oxygenation: A Subgroup Analysis of Two Large International Point-Prevalence Studies and the Role of Local Guidelines.
Nellis ME, Saini A, Spinella PC, Davis PJ, Steiner ME, Tucci M, Cushing M, Demaret P, Stanworth SJ, Leteurtre S, Karam O. Pediatric Plasma and Platelet Transfusions on Extracorporeal Membrane Oxygenation: A Subgroup Analysis of Two Large International Point-Prevalence Studies and the Role of Local Guidelines. Pediatric Critical Care Medicine 2020, 21: 267-275. PMID: 31644453, PMCID: PMC7060816, DOI: 10.1097/pcc.0000000000002160.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlood TransfusionChildChild, PreschoolExtracorporeal Membrane OxygenationFemaleHemorrhageHumansInfantInfant, NewbornIntensive Care Units, PediatricInternational Normalized RatioMalePlasmaPlatelet CountPlatelet TransfusionPractice Guidelines as TopicProspective StudiesSurveys and QuestionnairesConceptsExtracorporeal membrane oxygenationMembrane oxygenationPlatelet transfusionsTotal platelet countPlasma transfusionPlatelet countSubgroup analysisInstitutional protocolMedian increaseInternational point prevalence studyPediatric extracorporeal membrane oxygenationTotal median doseInternational normalized ratioML/Point prevalence studyPlatelet count valuesScreening weekMedian doseMild coagulopathyNormalized ratioInterventional studyLocal guidelinesObservational studyMedian reductionTransfusionExecutive summary: surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children
Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol ED, Carroll CL, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KFM, Joshi P, Karam O, Kneyber MCJ, Lemson J, MacLaren G, Mehta NM, Møller MH, Newth CJL, Nguyen TC, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HF, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P. Executive summary: surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Medicine 2020, 46: 1-9. PMID: 32030528, DOI: 10.1007/s00134-019-05877-7.Peer-Reviewed Original ResearchSurviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children
Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol ED, Carroll CL, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KFM, Joshi P, Karam O, Kneyber MCJ, Lemson J, MacLaren G, Mehta NM, Møller MH, Newth CJL, Nguyen TC, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HF, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P. Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children. Intensive Care Medicine 2020, 46: 10-67. PMID: 32030529, PMCID: PMC7095013, DOI: 10.1007/s00134-019-05878-6.Peer-Reviewed Original ResearchConceptsSepsis-associated organ dysfunctionOrgan dysfunctionSeptic shockBest practice statementsWeak recommendationKey international meetingsStand-alone meetingManagement of childrenManagement of infectionsQuality of evidenceEvidence-based recommendationsResuscitation of childrenGuideline development processMethodsThe panelInternational expertsRecommendations AssessmentAdjunctive therapyPractice patternsMetabolic therapyConsistent careLarge cohortPanel membersResearch prioritiesInternational guidelinesSystematic reviewExecutive Summary: Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children.
Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol ED, Carroll CL, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KFM, Joshi P, Karam O, Kneyber MCJ, Lemson J, MacLaren G, Mehta NM, Møller MH, Newth CJL, Nguyen TC, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HF, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P. Executive Summary: Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children. Pediatric Critical Care Medicine 2020, 21: 186-195. PMID: 32032264, DOI: 10.1097/pcc.0000000000002197.Peer-Reviewed Original ResearchSurviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children.
Weiss SL, Peters MJ, Alhazzani W, Agus MSD, Flori HR, Inwald DP, Nadel S, Schlapbach LJ, Tasker RC, Argent AC, Brierley J, Carcillo J, Carrol ED, Carroll CL, Cheifetz IM, Choong K, Cies JJ, Cruz AT, De Luca D, Deep A, Faust SN, De Oliveira CF, Hall MW, Ishimine P, Javouhey E, Joosten KFM, Joshi P, Karam O, Kneyber MCJ, Lemson J, MacLaren G, Mehta NM, Møller MH, Newth CJL, Nguyen TC, Nishisaki A, Nunnally ME, Parker MM, Paul RM, Randolph AG, Ranjit S, Romer LH, Scott HF, Tume LN, Verger JT, Williams EA, Wolf J, Wong HR, Zimmerman JJ, Kissoon N, Tissieres P. Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children. Pediatric Critical Care Medicine 2020, 21: e52-e106. PMID: 32032273, DOI: 10.1097/pcc.0000000000002198.Peer-Reviewed Original ResearchConceptsSepsis-associated organ dysfunctionOrgan dysfunctionSeptic shockBest practice statementsWeak recommendationKey international meetingsStand-alone meetingManagement of childrenQuality of evidenceManagement of infectionsEvidence-based recommendationsGuideline development processResuscitation of childrenInternational expertsRecommendations AssessmentAdjunctive therapyMetabolic therapyPractice patternsConsistent careLarge cohortPanel membersResearch prioritiesSystematic reviewInternational guidelinesDysfunction
2019
Anemia at Discharge From the PICU: A Bicenter Descriptive Study.
Demaret P, Valla FV, Behal H, Mimouni Y, Baudelet JB, Karam O, Recher M, Duhamel A, Tucci M, Javouhey E, Leteurtre S. Anemia at Discharge From the PICU: A Bicenter Descriptive Study. Pediatric Critical Care Medicine 2019, 20: e400-e409. PMID: 31246740, DOI: 10.1097/pcc.0000000000002015.Peer-Reviewed Original ResearchConceptsPediatric critical illnessPICU admissionPICU dischargeRisk of anemiaCritical illnessRisk markersHigher C-reactive protein levelsInotropic/vasopressor supportC-reactive protein levelsWorld Health Organization criteriaMedian hemoglobin levelRetrospective cohort studyElectronic medical recordsVasopressor supportPlasma transfusionCohort studyCreatinine levelsMultivariate adjustmentAnemic childrenHemoglobin levelsMechanical ventilationAnemia statusOrganization criteriaMedical recordsIll childrenInternational Study of the Epidemiology of Platelet Transfusions in Critically Ill Children With an Underlying Oncologic Diagnosis.
Nellis ME, Goel R, Karam O, Cushing MM, Davis PJ, Steiner ME, Tucci M, Stanworth SJ, Spinella PC. International Study of the Epidemiology of Platelet Transfusions in Critically Ill Children With an Underlying Oncologic Diagnosis. Pediatric Critical Care Medicine 2019, 20: e342-e351. PMID: 31107379, DOI: 10.1097/pcc.0000000000001987.Peer-Reviewed Original ResearchConceptsPlatelet transfusionsOncologic diagnosisIll childrenCurrent recommendationsHematopoietic stem cell transplantationCritically Ill ChildrenExtracorporeal life supportStem cell transplantationTotal platelet countMechanical ventilationPlatelet countAppropriate indicationsCell transplantationPediatric intensivistsSubgroup analysisObservational studyPlatelet functionTransfusionParent studyTherapeutic transfusionTotal plateletsLife supportDiagnosisVulnerable populationsSignificant differencesEffects of ABO Matching of Platelet Transfusions in Critically Ill Children*
Nellis ME, Goel R, Karam O, Cushing MM, Davis PJ, Steiner ME, Tucci M, Stanworth SJ, Spinella PC. Effects of ABO Matching of Platelet Transfusions in Critically Ill Children*. Pediatric Critical Care Medicine 2019, 20: e61-e69. PMID: 30422914, PMCID: PMC6709973, DOI: 10.1097/pcc.0000000000001779.Peer-Reviewed Original ResearchConceptsPlatelet transfusionsPlatelet countIll childrenTransfusion reactionsMinor incompatibilityCells/LABO-incompatible platelet transfusionsABO-compatible transfusionsABO-identical transfusionsABO-incompatible plateletsIncompatible platelet transfusionsCritically Ill ChildrenABO-identical plateletsABO-compatible plateletsMajor incompatibilityIncompatible plateletsNonbleeding patientsScreening weekPrimary outcomeSecondary outcomesABO matchingCompatible plateletsTransfusion doseMechanical ventilationOncologic diagnosis
2018
Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative
Valentine SL, Bembea MM, Muszynski JA, Cholette JM, Doctor A, Spinella PC, Steiner ME, Tucci M, Hassan NE, Parker RI, Lacroix J, Argent A, Carson JL, Remy KE, Demaret P, Emeriaud G, Kneyber MCJ, Guzzetta N, Hall MW, Macrae D, Karam O, Russell RT, Stricker PA, Vogel AM, Tasker RC, Turgeon AF, Schwartz SM, Willems A, Josephson CD, Luban NLC, Lehmann LE, Stanworth SJ, Zantek ND, Bunchman TE, Cheifetz IM, Fortenberry JD, Delaney M, van de Watering L, Robinson KA, Malone S, Steffen KM, Bateman ST. Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatric Critical Care Medicine 2018, 19: 884-898. PMID: 30180125, PMCID: PMC6126913, DOI: 10.1097/pcc.0000000000001613.Peer-Reviewed Original ResearchConceptsPediatric Critical Care TransfusionAnemia Expertise InitiativeRBC transfusion managementRBC transfusionIll childrenTransfusion managementConsensus recommendationsAnemia Expertise Initiative Consensus ConferenceDevelopment/UCLA Appropriateness MethodExpert consensus-based recommendationsImportant clinical guidanceRBC transfusion practicesAcute brain injuryCongenital heart diseaseConsensus-based recommendationsSearch of PubMedExpert consensus recommendationsUnnecessary RBC transfusionsNonhemorrhagic shockRecommendations AssessmentRespiratory failureCritical illnessHemorrhagic shockTransfusion practiceCochrane Library
2016
Potential Pediatric Organ Donors After Cardiac Death
Pregernig A, Karam O. Potential Pediatric Organ Donors After Cardiac Death. Transplantation Proceedings 2016, 48: 2588-2591. PMID: 27788786, DOI: 10.1016/j.transproceed.2016.06.049.Peer-Reviewed Original ResearchConceptsWithdrawal of careOrgan donorsAgonal timeMaximal resuscitationCardiac deathPediatric populationNeonatal intensive care unitOrgan donationBrain-dead childrenIntensive care unitOrgan donor poolTransplant waiting listPediatric organ donorPotential organ donorsOrgan donation programsMedical contraindicationsCare unitRetrospective studyDonor poolWaiting listDonation programDonor populationCareChildrenResuscitationKetosis After Cardiopulmonary Bypass in Children Is Associated With an Inadequate Balance Between Oxygen Transport and Consumption*
Klee P, Arni D, Saudan S, Schwitzgebel VM, Sharma R, Karam O, Rimensberger PC. Ketosis After Cardiopulmonary Bypass in Children Is Associated With an Inadequate Balance Between Oxygen Transport and Consumption*. Pediatric Critical Care Medicine 2016, 17: 852-859. PMID: 27472253, DOI: 10.1097/pcc.0000000000000880.Peer-Reviewed Original ResearchConceptsIndependent risk factorPICU admissionCardiopulmonary bypassInsulin treatmentCardiac surgeryRisk factorsPostoperative blood glucose levelsProspective observational studyPatients 6 monthsSubset of patientsSubgroup of patientsVenous oxygen saturationTight glycemic controlBlood glucose levelsGlycemic controlTertiary PICUGlucose intakeWorse outcomesPatient outcomesHigh prevalenceObservational studyGlucose levelsOxygen saturationMetabolic constellationAdmission
2015
Indications and Effects of Plasma Transfusions in Critically Ill Children
Karam O, Demaret P, Shefler A, Leteurtre S, Spinella PC, Stanworth SJ, Tucci M. Indications and Effects of Plasma Transfusions in Critically Ill Children. American Journal Of Respiratory And Critical Care Medicine 2015, 191: 1395-1402. PMID: 25859890, DOI: 10.1164/rccm.201503-0450oc.Peer-Reviewed Original ResearchConceptsInternational normalized ratioMedian international normalized ratioPlasma transfusionIll childrenCoagulation testsBaseline international normalized ratioPediatric intensive care patientsPediatric intensive care unitPartial thromboplastin time valuesCritically Ill ChildrenPoint prevalence studyIntensive care patientsIntensive care unitStrong evidence baseMinor bleedingPostoperative bleedingMost patientsPatient characteristicsTransfusion strategyCare patientsCare unitCritical bleedingNormalized ratioPrimary indicationTransfusion
2013
Association between plasma transfusions and clinical outcome in critically ill children: a prospective observational study
Karam O, Lacroix J, Robitaille N, Rimensberger PC, Tucci M. Association between plasma transfusions and clinical outcome in critically ill children: a prospective observational study. Vox Sanguinis 2013, 104: 342-349. PMID: 23294337, DOI: 10.1111/vox.12009.Peer-Reviewed Original ResearchConceptsProgressive multiple organ dysfunction syndromeMultiple organ dysfunction syndromeOrgan dysfunction syndromeIntensive care unit lengthPlasma transfusionDysfunction syndromeClinical outcomesIll childrenNosocomial infectionsCare unitOdds ratioOutcome measuresPediatric intensive care unitPediatric critical care unitProspective pediatric studiesAdult trauma patientsProspective observational studySingle-center studySecondary outcome measuresWorse clinical outcomesExtracorporeal life supportPrimary outcome measureSeverity of illnessIntensive care unitCritical care units
2010
Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients
Gauvin F, Spinella PC, Lacroix J, Choker G, Ducruet T, Karam O, Hébert PC, Hutchison JS, Hume HA, Tucci M, Network O. Association between length of storage of transfused red blood cells and multiple organ dysfunction syndrome in pediatric intensive care patients. Transfusion 2010, 50: 1902-1913. PMID: 20456697, DOI: 10.1111/j.1537-2995.2010.02661.x.Peer-Reviewed Original ResearchConceptsMultiple organ dysfunction syndromeProgressive multiple organ dysfunction syndromeOrgan dysfunction syndromeIll childrenDysfunction syndromePediatric Logistic Organ Dysfunction scoreRed blood cell storage timeLogistic Organ Dysfunction scorePediatric intensive care patientsOrgan dysfunction scoreIntensive care patientsRBC storage timeMultivariate logistic regressionRed blood cellsDysfunction scoreCare patientsRestrictive groupIndependent associationCohort analysisPatientsHigh mortalityGreater riskLogistic regressionRBC unitsStudy design