2023
Bleeding in Critically Ill Children With Malignancy or Hematopoietic Cell Transplant: A Single-Center Prospective Cohort Study
Levasseur J, Fikse L, Mauguen A, Killinger J, Karam O, Nellis M. Bleeding in Critically Ill Children With Malignancy or Hematopoietic Cell Transplant: A Single-Center Prospective Cohort Study. Pediatric Critical Care Medicine 2023, 24: e602-e610. PMID: 37678406, PMCID: PMC10843653, DOI: 10.1097/pcc.0000000000003374.Peer-Reviewed Original ResearchMeSH KeywordsChildChild, PreschoolCritical IllnessFemaleHematopoietic Stem Cell TransplantationHemorrhageHumansInfantIntensive Care Units, PediatricMaleNeoplasmsProspective StudiesRetrospective StudiesConceptsProspective cohort studyBleeding episodesSevere bleedingIll childrenCohort studyCell transplantIncidence rateLaboratory valuesMinimal bleedingRadiation therapySingle-center prospective cohort studyAssociated Patient CharacteristicsHigher PICU mortalityNew bleeding episodesOnly laboratory valueHematopoietic cell transplantCritically Ill ChildrenLow platelet countSevere bleeding episodesStem cell transplantPatient demographic dataSpecialized cancer hospitalModerate bleeding episodesYears of ageLonger PICUThe Effects of Expectation Setting and Bundle Consent on Acute Caregiver Stress in the PICU: A Randomized Controlled Trial
Goldstein G, Karam O, Miller Ferguson N. The Effects of Expectation Setting and Bundle Consent on Acute Caregiver Stress in the PICU: A Randomized Controlled Trial. Pediatric Critical Care Medicine 2023, 24: 692-700. PMID: 37125809, DOI: 10.1097/pcc.0000000000003265.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentCaregiversChildChild, PreschoolHumansInfantInfant, NewbornInformed ConsentIntensive Care Units, PediatricMotivationParentsProspective StudiesConceptsBundled consentSeverity of illnessParents' perceptionsParents/guardians of patientsParents' perceived severityNegative mental health consequencesMental health consequencesPercentage of parentsCaregiver stressPersonal vulnerabilityChild's illnessChild's admissionControl groupChild's conditionExperimental groupPatients admitted to PICUDemographic surveyHealth consequencesLife-threatening natureStress burdenExpectation settingDemographic variablesControl weekIllnessAdmitted to PICU
2021
Factors Associated With Initiation of Extracorporeal Cardiopulmonary Resuscitation in the Pediatric Population: An International Survey
Nguyen DA, De Mul A, Hoskote AU, Cogo P, da Cruz EM, Erickson S, Lasa JJ, Thiagarajan RR, Bembea MM, Karam O, ESPNIC A. Factors Associated With Initiation of Extracorporeal Cardiopulmonary Resuscitation in the Pediatric Population: An International Survey. ASAIO Journal 2021, 68: 413-418. PMID: 34074851, DOI: 10.1097/mat.0000000000001495.Peer-Reviewed Original ResearchMeSH KeywordsCardiopulmonary ResuscitationChildExtracorporeal Membrane OxygenationHeart ArrestHumansInfant, NewbornIntensive Care Units, PediatricRetrospective StudiesConceptsExtracorporeal cardiopulmonary resuscitationCPR durationCardiac arrestCardiopulmonary resuscitationIntensive care unit locationPediatric critical care physiciansCPR qualityPostoperative cardiac surgeryChronic respiratory failureMultiple organ failurePediatric extracorporeal cardiopulmonary resuscitationDuration of CPRPediatric critical care environmentCritical care physiciansDoses of adrenalineFormer preterm childrenLocation of arrestUnwitnessed cardiac arrestExtracorporeal membrane oxygenation teamBetter CPR qualityCritical care environmentECPR initiationECMO initiationRespiratory failureClinical determinants
2020
Effect of platelet storage duration on clinical outcomes and incremental platelet change in critically ill children
Nellis ME, Spinella PC, Tucci M, Stanworth SJ, Steiner ME, Cushing MM, Davis PJ, Karam O, The Pediatric Acute Lung Injury and Sepsis Investigators network P. Effect of platelet storage duration on clinical outcomes and incremental platelet change in critically ill children. Transfusion 2020, 60: 2849-2858. PMID: 32959409, PMCID: PMC8396066, DOI: 10.1111/trf.16094.Peer-Reviewed Original ResearchConceptsClinical outcomesIll childrenPLT transfusionsObservational point prevalence studyPediatric intensive care unitStorage ageSafety of plateletsFurther prospective evaluationPoint prevalence studyIntensive care unitImmune system dysfunctionFebrile transfusion reactionsDays of ageScreening weekCare unitProspective evaluationSystem dysfunctionTransfusion reactionsPlatelet changesTransfusionPLT countTransfusion efficacyAge groupsSecondary analysisSignificant associationHow 217 Pediatric Intensivists Manage Anemia at PICU Discharge: Online Responses to an International Survey.
Demaret P, Karam O, Labreuche Bst J, Chiusolo F, Mayordomo Colunga J, Erickson S, Nellis ME, Perez MH, Ray S, Tucci M, Willems A, Duhamel A, Lebrun F, Loeckx I, Mulder A, Leteurtre S. How 217 Pediatric Intensivists Manage Anemia at PICU Discharge: Online Responses to an International Survey. Pediatric Critical Care Medicine 2020, 21: e342-e353. PMID: 32217901, DOI: 10.1097/pcc.0000000000002307.Peer-Reviewed Original ResearchMeSH KeywordsAnemiaChildErythrocyte TransfusionEuropeHemoglobinsHumansIntensive Care Units, PediatricNorth AmericaPatient DischargeSurveys and QuestionnairesConceptsManagement of anemiaPICU dischargePediatric intensivistsTransfusion thresholdCardiac surgeryHemoglobin levelsHemorrhagic shockPrescription of erythropoietinRestrictive transfusion strategyCyanotic heart diseaseCraniofacial surgeryVentricular dysfunctionCritical illnessTransfusion strategyRBC transfusionAcute phaseHeart diseaseSupplemental ironThird of respondentsAnemiaAppropriate managementIntensivistsSurgeryOptimal managementPolytraumaPediatric Plasma and Platelet Transfusions on Extracorporeal Membrane Oxygenation: A Subgroup Analysis of Two Large International Point-Prevalence Studies and the Role of Local Guidelines.
Nellis ME, Saini A, Spinella PC, Davis PJ, Steiner ME, Tucci M, Cushing M, Demaret P, Stanworth SJ, Leteurtre S, Karam O. Pediatric Plasma and Platelet Transfusions on Extracorporeal Membrane Oxygenation: A Subgroup Analysis of Two Large International Point-Prevalence Studies and the Role of Local Guidelines. Pediatric Critical Care Medicine 2020, 21: 267-275. PMID: 31644453, PMCID: PMC7060816, DOI: 10.1097/pcc.0000000000002160.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentBlood TransfusionChildChild, PreschoolExtracorporeal Membrane OxygenationFemaleHemorrhageHumansInfantInfant, NewbornIntensive Care Units, PediatricInternational Normalized RatioMalePlasmaPlatelet CountPlatelet TransfusionPractice Guidelines as TopicProspective StudiesSurveys and QuestionnairesConceptsExtracorporeal membrane oxygenationMembrane oxygenationPlatelet transfusionsTotal platelet countPlasma transfusionPlatelet countSubgroup analysisInstitutional protocolMedian increaseInternational point prevalence studyPediatric extracorporeal membrane oxygenationTotal median doseInternational normalized ratioML/Point prevalence studyPlatelet count valuesScreening weekMedian doseMild coagulopathyNormalized ratioInterventional studyLocal guidelinesObservational studyMedian reductionTransfusion
2019
Quantifiable Bleeding in Children Supported by Extracorporeal Membrane Oxygenation and Outcome.
Nellis ME, Dalton H, Karam O. Quantifiable Bleeding in Children Supported by Extracorporeal Membrane Oxygenation and Outcome. Critical Care Medicine 2019, 47: e886-e892. PMID: 31449061, PMCID: PMC8608374, DOI: 10.1097/ccm.0000000000003968.Peer-Reviewed Original ResearchConceptsChest tube bleedingExtracorporeal membrane oxygenationCollaborative Pediatric Critical Care Research NetworkMembrane oxygenationChest tubeClinical outcomesPlatelet countML/Large observational cohort studyEunice Kennedy Shriver National InstituteCritical Care Research NetworkPICU-free daysPercent of patientsObservational cohort studyWorse clinical outcomesHuman Development Collaborative Pediatric Critical Care Research NetworkMembrane oxygenation specialistsHospital mortalityTransfusion volumeCohort studyHeparin doseConsecutive patientsThrombotic eventsPediatric institutionHemostatic testsAnemia at Discharge From the PICU: A Bicenter Descriptive Study.
Demaret P, Valla FV, Behal H, Mimouni Y, Baudelet JB, Karam O, Recher M, Duhamel A, Tucci M, Javouhey E, Leteurtre S. Anemia at Discharge From the PICU: A Bicenter Descriptive Study. Pediatric Critical Care Medicine 2019, 20: e400-e409. PMID: 31246740, DOI: 10.1097/pcc.0000000000002015.Peer-Reviewed Original ResearchConceptsPediatric critical illnessPICU admissionPICU dischargeRisk of anemiaCritical illnessRisk markersHigher C-reactive protein levelsInotropic/vasopressor supportC-reactive protein levelsWorld Health Organization criteriaMedian hemoglobin levelRetrospective cohort studyElectronic medical recordsVasopressor supportPlasma transfusionCohort studyCreatinine levelsMultivariate adjustmentAnemic childrenHemoglobin levelsMechanical ventilationAnemia statusOrganization criteriaMedical recordsIll childrenDevelopment of an Antibiotic Guideline for Children With Suspected Ventilator-Associated Infections.
Shein SL, Karam O, Beardsley A, Karsies T, Prentice E, Tarquinio KM, Willson DF. Development of an Antibiotic Guideline for Children With Suspected Ventilator-Associated Infections. Pediatric Critical Care Medicine 2019, 20: 697-706. PMID: 30985606, DOI: 10.1097/pcc.0000000000001942.Peer-Reviewed Original ResearchConceptsVentilator-associated infectionPhase 1 dataAntibiotic guidelinesGuideline scoreAntibiotic usePediatric Logistic Organ Dysfunction-2 scoreDuration of antibioticsPICU-free daysVentilator-Associated InfectionsVentilator-free daysInitiation of antibioticsProspective data collectionPhase 3Median ageMechanical ventilationVentilated childrenScore 3Consensus conferenceClinical testingScoring systemInfectionLiterature searchExpert panelAntibioticsScoresInternational Study of the Epidemiology of Platelet Transfusions in Critically Ill Children With an Underlying Oncologic Diagnosis.
Nellis ME, Goel R, Karam O, Cushing MM, Davis PJ, Steiner ME, Tucci M, Stanworth SJ, Spinella PC. International Study of the Epidemiology of Platelet Transfusions in Critically Ill Children With an Underlying Oncologic Diagnosis. Pediatric Critical Care Medicine 2019, 20: e342-e351. PMID: 31107379, DOI: 10.1097/pcc.0000000000001987.Peer-Reviewed Original ResearchConceptsPlatelet transfusionsOncologic diagnosisIll childrenCurrent recommendationsHematopoietic stem cell transplantationCritically Ill ChildrenExtracorporeal life supportStem cell transplantationTotal platelet countMechanical ventilationPlatelet countAppropriate indicationsCell transplantationPediatric intensivistsSubgroup analysisObservational studyPlatelet functionTransfusionParent studyTherapeutic transfusionTotal plateletsLife supportDiagnosisVulnerable populationsSignificant differencesCriteria for Clinically Relevant Bleeding in Critically Ill Children
Karam O, Nellis ME, Zantek ND, Lacroix J, Faustino EVS. Criteria for Clinically Relevant Bleeding in Critically Ill Children. Pediatric Critical Care Medicine 2019, Publish Ahead of Print: &na;. PMID: 30575698, DOI: 10.1097/pcc.0000000000001828.Peer-Reviewed Original ResearchMeSH KeywordsAdultClinical Decision-MakingCritical IllnessFemaleHemorrhageHumansIntensive Care Units, PediatricMaleMiddle AgedMultiple Organ FailureNurse PractitionersPediatriciansConceptsRelevant bleedingStreaks of bloodIll childrenEndotracheal tubeClinical relevancePediatric critical care physiciansClinically Relevant BleedingML/Critical care physiciansCritical illnessIll adultsOrgan failureCare physiciansGastric tubeClinical significanceNurse practitionersBleedingDiagnostic criteriaClinical practiceResponse rateIntensivists' perceptionWeb-based surveyDiagnostic definitionRespondents' geographical locationBloodEffects of ABO Matching of Platelet Transfusions in Critically Ill Children*
Nellis ME, Goel R, Karam O, Cushing MM, Davis PJ, Steiner ME, Tucci M, Stanworth SJ, Spinella PC. Effects of ABO Matching of Platelet Transfusions in Critically Ill Children*. Pediatric Critical Care Medicine 2019, 20: e61-e69. PMID: 30422914, PMCID: PMC6709973, DOI: 10.1097/pcc.0000000000001779.Peer-Reviewed Original ResearchConceptsPlatelet transfusionsPlatelet countIll childrenTransfusion reactionsMinor incompatibilityCells/LABO-incompatible platelet transfusionsABO-compatible transfusionsABO-identical transfusionsABO-incompatible plateletsIncompatible platelet transfusionsCritically Ill ChildrenABO-identical plateletsABO-compatible plateletsMajor incompatibilityIncompatible plateletsNonbleeding patientsScreening weekPrimary outcomeSecondary outcomesABO matchingCompatible plateletsTransfusion doseMechanical ventilationOncologic diagnosis
2018
Recommendations on RBC Transfusion in Critically Ill Children With Nonlife-Threatening Bleeding or Hemorrhagic Shock From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative
Karam O, Russell RT, Stricker P, Vogel AM, Bateman ST, Valentine SL, Spinella PC. Recommendations on RBC Transfusion in Critically Ill Children With Nonlife-Threatening Bleeding or Hemorrhagic Shock From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative. Pediatric Critical Care Medicine 2018, 19: s127-s132. PMID: 30161067, PMCID: PMC6121734, DOI: 10.1097/pcc.0000000000001605.Peer-Reviewed Original ResearchMeSH KeywordsAnemiaChildCritical CareCritical IllnessErythrocyte CountErythrocyte TransfusionEvidence-Based MedicineHumansIntensive Care Units, PediatricShock, HemorrhagicConceptsPediatric Critical Care TransfusionAnemia Expertise InitiativeRBC transfusion managementRBC transfusionIll childrenHemorrhagic shockAcute bleedingTransfusion managementAnemia Expertise Initiative Consensus ConferenceDevelopment/UCLA Appropriateness MethodLow-titer group O whole bloodHemoglobin concentrationExpert-based clinical recommendationsGroup O whole bloodWhole bloodCritically Ill ChildrenCochrane Library databasesPediatric-specific recommendationsRecommendations AssessmentHemostatic resuscitationTransfusion ratioFuture studiesAppropriateness MethodClinical recommendationsTransfusion
2017
Outcomes Related to the Use of Frozen Plasma or Pooled Solvent/Detergent-Treated Plasma in Critically Ill Children*
Camazine MN, Karam O, Colvin R, Leteurtre S, Demaret P, Tucci M, Muszynski JA, Stanworth S, Spinella PC. Outcomes Related to the Use of Frozen Plasma or Pooled Solvent/Detergent-Treated Plasma in Critically Ill Children*. Pediatric Critical Care Medicine 2017, 18: e215-e223. PMID: 28350560, DOI: 10.1097/pcc.0000000000001149.Peer-Reviewed Original ResearchConceptsSolvent detergent plasmaPlasma 24 hoursICU mortalityIll childrenPlasma transfusionStudy groupHours groupPretransfusion international normalized ratioSolvent/detergent-treated plasmaCritically Ill ChildrenInternational normalized ratioHypothesis-generating dataMultivariable logistic regressionIllness scoresImproved survivalMedian ageAdjusted analysisNormalized ratioPrimary indicationIndependent associationFrozen plasmaObservational studyPlasma useLactate valuesPatientsFactors influencing plasma transfusion practices in paediatric intensive care units around the world
Karam O, Demaret P, Duhamel A, Shefler A, Spinella PC, Tucci M, Leteurtre S, Stanworth SJ, investigators T. Factors influencing plasma transfusion practices in paediatric intensive care units around the world. Vox Sanguinis 2017, 112: 140-149. PMID: 28176380, DOI: 10.1111/vox.12490.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlood Component TransfusionFemaleHemorrhageHumansIntensive Care Units, PediatricInternational Normalized RatioMalePartial Thromboplastin TimePhysiciansSurveys and QuestionnairesConceptsPlasma transfusion practicesPlasma transfusionTransfusion practiceCoagulation testsPediatric intensive care unitInternational pediatric studiesLocal transfusion serviceAbnormal coagulation testsIntensive care unitEfficacy of transfusionSignificant relevant factorTransfusion policyTransfusion rateCare unitAppropriate indicationsPediatric studiesFrequent treatmentTransfusionResponse rateTransfusion servicesLocal investigatorsPatientsCenter characteristicsWide variationBleeding
2015
Clinical Outcomes Associated With RBC Transfusions in Critically Ill Children
Demaret P, Tucci M, Karam O, Trottier H, Ducruet T, Lacroix J. Clinical Outcomes Associated With RBC Transfusions in Critically Ill Children. Pediatric Critical Care Medicine 2015, 16: 505-514. PMID: 25905491, DOI: 10.1097/pcc.0000000000000423.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesChildChild, PreschoolCritical CareCritical IllnessErythrocyte TransfusionFemaleHumansInfantInfant, NewbornIntensive Care Units, PediatricLength of StayMaleMultiple Organ FailureOxygenPartial PressureProspective StudiesRenal Replacement TherapyRespiration, ArtificialTime FactorsTreatment OutcomeConceptsProgressive multiple organ dysfunction syndromeMultiple organ dysfunction syndromeFirst RBC transfusionOrgan dysfunction syndromeRBC transfusionIll childrenDysfunction syndromeRenal replacement therapyTertiary children's hospitalCritically Ill ChildrenProspective observational studyArterial partial pressurePICU lengthProlonged PICUPICU patientsMedical chartsClinical outcomesMechanical ventilationMultivariable analysisChildren's HospitalPotential confoundersReplacement therapyConsecutive admissionsPotential complicationsOdds ratioIndications and Effects of Plasma Transfusions in Critically Ill Children
Karam O, Demaret P, Shefler A, Leteurtre S, Spinella PC, Stanworth SJ, Tucci M. Indications and Effects of Plasma Transfusions in Critically Ill Children. American Journal Of Respiratory And Critical Care Medicine 2015, 191: 1395-1402. PMID: 25859890, DOI: 10.1164/rccm.201503-0450oc.Peer-Reviewed Original ResearchConceptsInternational normalized ratioMedian international normalized ratioPlasma transfusionIll childrenCoagulation testsBaseline international normalized ratioPediatric intensive care patientsPediatric intensive care unitPartial thromboplastin time valuesCritically Ill ChildrenPoint prevalence studyIntensive care patientsIntensive care unitStrong evidence baseMinor bleedingPostoperative bleedingMost patientsPatient characteristicsTransfusion strategyCare patientsCare unitCritical bleedingNormalized ratioPrimary indicationTransfusion
2013
Patient–Ventilator Asynchrony During Noninvasive Pressure Support Ventilation and Neurally Adjusted Ventilatory Assist in Infants and Children
Vignaux L, Grazioli S, Piquilloud L, Bochaton N, Karam O, Levy-Jamet Y, Jaecklin T, Tourneux P, Jolliet P, Rimensberger PC. Patient–Ventilator Asynchrony During Noninvasive Pressure Support Ventilation and Neurally Adjusted Ventilatory Assist in Infants and Children. Pediatric Critical Care Medicine 2013, 14: e357-e364. PMID: 23863816, DOI: 10.1097/pcc.0b013e3182917922.Peer-Reviewed Original ResearchConceptsAsynchrony eventsVentilator assistNoninvasive ventilationPremature cyclingVentilatory assistPressure supportAsynchrony indexNoninvasive pressure support ventilationProspective randomized cross-over studyPositive end-expiratory pressureRandomized cross-over studyMaximum airway pressurePressure support ventilationEnd-expiratory pressureCross-over studyPatient-ventilator asynchronyPatient-ventilator synchronyAdjusted Ventilatory AssistType of asynchronyAirway pressureSupport ventilationClinical impactInspiratory timeTrigger delayDouble triggeringOptimizing Patient-Ventilator Synchrony During Invasive Ventilator Assist in Children and Infants Remains a Difficult Task*
Vignaux L, Grazioli S, Piquilloud L, Bochaton N, Karam O, Jaecklin T, Levy-Jamet Y, Tourneux P, Jolliet P, Rimensberger PC. Optimizing Patient-Ventilator Synchrony During Invasive Ventilator Assist in Children and Infants Remains a Difficult Task*. Pediatric Critical Care Medicine 2013, 14: e316-e325. PMID: 23842584, DOI: 10.1097/pcc.0b013e31828a8606.Peer-Reviewed Original ResearchMeSH KeywordsChild, PreschoolCross-Over StudiesFemaleHumansInfantIntensive Care Units, PediatricIntubation, IntratrachealMaleProspective StudiesRespiration, ArtificialConceptsAsynchrony eventsVentilatory assistExpiratory triggerInspiratory timeAsynchrony indexNeonatal intensive care unitIntensive care unitPressure support modePatient-ventilator synchronyPressure supportMedian asynchrony indexCare unitCrossover studyMechanical ventilationVentilated childrenVentilator assistUniversity HospitalPremature cyclingClinical impactRandom orderVentilation periodIneffective effortsFurther studiesChildrenSupport modeInternational survey on plasma transfusion practices in critically ill children
Karam O, Tucci M, Lacroix J, Rimensberger PC, Network C. International survey on plasma transfusion practices in critically ill children. Transfusion 2013, 54: 1125-1132. PMID: 24032693, DOI: 10.1111/trf.12393.Peer-Reviewed Original ResearchConceptsTraumatic brain injuryPediatric critical care physiciansPlasma transfusion practicesInternational normalized ratioCritical care physiciansPlasma transfusionTransfusion practiceCare physiciansRed blood cell transfusion practicesAbnormal international normalized ratioPediatric critical care unitCardiac postoperative patientsTransfusion practice patternsSeptic shock patientsDemographic characteristicsCritical care unitsPartial thromboplastin timeProportion of physiciansFallot correctionNonbleeding patientsMinor bleedingShock patientsTransfusion thresholdPostoperative patientsSeptic shock