Length of storage and in vitro immunomodulation induced by prestorage leukoreduced red blood cells
Karam O, Tucci M, Toledano BJ, Robitaille N, Cousineau J, Thibault L, Lacroix J, Le Deist F. Length of storage and in vitro immunomodulation induced by prestorage leukoreduced red blood cells. Transfusion 2009, 49: 2326-2334. PMID: 19624600, DOI: 10.1111/j.1537-2995.2009.02319.x.Peer-Reviewed Original ResearchConceptsWhole blood culturesT cell activationCD25 expressionBlood culturesLeukoreduced RBCsRBC unitsBlood cellsRed blood cell unitsIL-10 levelsTNF-alpha levelsIL-6 levelsTNF-alpha productionTumor necrosis factorWhite blood cellsRed blood cellsIL-10Blood recipientsCytokine productionIL-6Immunomodulatory effectsCytokine releaseNecrosis factorRBC supernatantsDay 1Day 24