2020
Potential Neurodevelopmental Effects of Pediatric Intensive Care Sedation and Analgesia: Repetitive Benzodiazepine and Opioid Exposure Alters Expression of Glial and Synaptic Proteins in Juvenile Rats
Iqbal O'Meara AM, Miller Ferguson N, Zven SE, Karam OL, Meyer LC, Bigbee JW, Sato-Bigbee C. Potential Neurodevelopmental Effects of Pediatric Intensive Care Sedation and Analgesia: Repetitive Benzodiazepine and Opioid Exposure Alters Expression of Glial and Synaptic Proteins in Juvenile Rats. Critical Care Explorations 2020, 2: e0105. PMID: 32426747, PMCID: PMC7188419, DOI: 10.1097/cce.0000000000000105.Peer-Reviewed Original ResearchS100 calcium-binding protein BCalcium-binding protein BGlial fibrillary acidic proteinFibrillary acidic proteinCalcium-binding adaptor molecule 1Adaptor molecule 1Acidic proteinMyelin basic proteinMorphine animalsNeurodevelopmental effectsMolecule-1Intensive care sedationInjection of morphinePotential neurodevelopmental effectsFemale Long-Evans ratsPostnatal day 23Postnatal day 18Novel rodent modelLong-Evans ratsBasic science laboratoryProtein BBasic proteinPICU patientsNeurologic dysfunctionMidazolam administration
2015
Clinical Outcomes Associated With RBC Transfusions in Critically Ill Children
Demaret P, Tucci M, Karam O, Trottier H, Ducruet T, Lacroix J. Clinical Outcomes Associated With RBC Transfusions in Critically Ill Children. Pediatric Critical Care Medicine 2015, 16: 505-514. PMID: 25905491, DOI: 10.1097/pcc.0000000000000423.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesChildChild, PreschoolCritical CareCritical IllnessErythrocyte TransfusionFemaleHumansInfantInfant, NewbornIntensive Care Units, PediatricLength of StayMaleMultiple Organ FailureOxygenPartial PressureProspective StudiesRenal Replacement TherapyRespiration, ArtificialTime FactorsTreatment OutcomeConceptsProgressive multiple organ dysfunction syndromeMultiple organ dysfunction syndromeFirst RBC transfusionOrgan dysfunction syndromeRBC transfusionIll childrenDysfunction syndromeRenal replacement therapyTertiary children's hospitalCritically Ill ChildrenProspective observational studyArterial partial pressurePICU lengthProlonged PICUPICU patientsMedical chartsClinical outcomesMechanical ventilationMultivariable analysisChildren's HospitalPotential confoundersReplacement therapyConsecutive admissionsPotential complicationsOdds ratio