2020
Individual‐ and hospital‐level correlates of red blood cell, platelet, and plasma transfusions among hospitalized children and neonates: a nationally representative study in the United States
Goel R, Josephson CD, Patel EU, Petersen MR, Packman Z, Gehrie E, Bloch EM, Lokhandwala P, Ness PM, Katz L, Nellis M, Karam O, Tobian AAR. Individual‐ and hospital‐level correlates of red blood cell, platelet, and plasma transfusions among hospitalized children and neonates: a nationally representative study in the United States. Transfusion 2020, 60: 1700-1712. PMID: 32589286, PMCID: PMC7951993, DOI: 10.1111/trf.15855.Peer-Reviewed Original ResearchConceptsAdjusted odds ratioRed blood cellsRBC transfusionPlatelet transfusionsPlasma transfusionAge groupsBlood cellsElective admission statusProportion of neonatesMultivariable logistic regressionOlder age groupsTotal hospitalizationsPrimary outcomeSecondary outcomesHospitalized neonatesNonwhite raceHospitalized childrenFemale sexOverall prevalenceOdds ratioHospital birthsPediatric dischargesTransfusion proceduresTransfusionHigh risk
2017
Anemia at pediatric intensive care unit discharge: prevalence and risk markers
Demaret P, Karam O, Tucci M, Lacroix J, Behal H, Duhamel A, Lebrun F, Mulder A, Leteurtre S. Anemia at pediatric intensive care unit discharge: prevalence and risk markers. Annals Of Intensive Care 2017, 7: 107. PMID: 29067568, PMCID: PMC5655401, DOI: 10.1186/s13613-017-0328-8.Peer-Reviewed Original ResearchPICU dischargePICU admissionRisk markersOdds ratioPediatric intensive care unit admissionPediatric intensive care unit dischargeIntensive care unit admissionTertiary care children's hospitalIntensive care unit dischargeCare unit admissionNon-cardiac surgeryPrevalence of anemiaProspective observational studyRisk of anemiaConsequences of anemiaMedian Hb levelStrong risk markerUnit admissionAge-based definitionCritical illnessHospital dischargeMultivariate adjustmentAnemic childrenMedical chartsHemoglobin levels
2015
Clinical Outcomes Associated With RBC Transfusions in Critically Ill Children
Demaret P, Tucci M, Karam O, Trottier H, Ducruet T, Lacroix J. Clinical Outcomes Associated With RBC Transfusions in Critically Ill Children. Pediatric Critical Care Medicine 2015, 16: 505-514. PMID: 25905491, DOI: 10.1097/pcc.0000000000000423.Peer-Reviewed Original ResearchMeSH KeywordsCase-Control StudiesChildChild, PreschoolCritical CareCritical IllnessErythrocyte TransfusionFemaleHumansInfantInfant, NewbornIntensive Care Units, PediatricLength of StayMaleMultiple Organ FailureOxygenPartial PressureProspective StudiesRenal Replacement TherapyRespiration, ArtificialTime FactorsTreatment OutcomeConceptsProgressive multiple organ dysfunction syndromeMultiple organ dysfunction syndromeFirst RBC transfusionOrgan dysfunction syndromeRBC transfusionIll childrenDysfunction syndromeRenal replacement therapyTertiary children's hospitalCritically Ill ChildrenProspective observational studyArterial partial pressurePICU lengthProlonged PICUPICU patientsMedical chartsClinical outcomesMechanical ventilationMultivariable analysisChildren's HospitalPotential confoundersReplacement therapyConsecutive admissionsPotential complicationsOdds ratio
2013
Association between plasma transfusions and clinical outcome in critically ill children: a prospective observational study
Karam O, Lacroix J, Robitaille N, Rimensberger PC, Tucci M. Association between plasma transfusions and clinical outcome in critically ill children: a prospective observational study. Vox Sanguinis 2013, 104: 342-349. PMID: 23294337, DOI: 10.1111/vox.12009.Peer-Reviewed Original ResearchConceptsProgressive multiple organ dysfunction syndromeMultiple organ dysfunction syndromeOrgan dysfunction syndromeIntensive care unit lengthPlasma transfusionDysfunction syndromeClinical outcomesIll childrenNosocomial infectionsCare unitOdds ratioOutcome measuresPediatric intensive care unitPediatric critical care unitProspective pediatric studiesAdult trauma patientsProspective observational studySingle-center studySecondary outcome measuresWorse clinical outcomesExtracorporeal life supportPrimary outcome measureSeverity of illnessIntensive care unitCritical care units
2010
Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational study
Karam O, Tucci M, Bateman ST, Ducruet T, Spinella PC, Randolph AG, Lacroix J. Association between length of storage of red blood cell units and outcome of critically ill children: a prospective observational study. Critical Care 2010, 14: r57. PMID: 20377853, PMCID: PMC2887178, DOI: 10.1186/cc8953.Peer-Reviewed Original ResearchConceptsPediatric intensive care unitMultiple organ dysfunction syndromeRed blood cell unitsOrgan dysfunction syndromeDysfunction syndromeIll childrenPICU lengthClinical outcomesOdds ratioObservational studyMultiple logistic regression modelProspective observational studyWorse clinical outcomesPrimary outcome measureIntensive care unitNorth American centersCell unitsLogistic regression modelsSecondary outcomesConsecutive patientsOrgan dysfunctionCare unitMedian lengthProspective studyClinical impact