1987
In vivo 31P and in vitro 1H nuclear magnetic resonance study of hypoglycemia during neonatal seizure
Young R, Cowan B, Petroff O, Novotny E, Dunham S, Briggs R. In vivo 31P and in vitro 1H nuclear magnetic resonance study of hypoglycemia during neonatal seizure. Annals Of Neurology 1987, 22: 622-628. PMID: 3426168, DOI: 10.1002/ana.410220511.Peer-Reviewed Original ResearchConceptsNeonatal seizuresBrain energy stateBicuculline-induced seizuresBrain glucose concentrationsCerebral blood flowBeta-hydroxybutyrate levelsBrain metabolic stateVivo 31P nuclear magnetic resonance spectroscopyBrain alanineAdenosine triphosphate levelsNeonatal dogsPhosphocreatine levelsSignificant elevationBlood flowSeizuresMagnetic resonance spectroscopyBrain extractsVivo 31PHypoglycemiaAdverse effectsTriphosphate levelsGlucose concentrationGreater declineFurther deteriorationMetabolic state
1984
In vivo phosphorus nuclear magnetic resonance spectroscopy in status epilepticus
Petroff O, Prichard J, Behar K, Alger J, Shulman R. In vivo phosphorus nuclear magnetic resonance spectroscopy in status epilepticus. Annals Of Neurology 1984, 16: 169-177. PMID: 6476792, DOI: 10.1002/ana.410160203.Peer-Reviewed Original ResearchConceptsStatus epilepticusSeizure activityVivo phosphorus nuclear magnetic resonance spectroscopyControl valuesBicuculline-induced status epilepticusAdequate cerebral perfusionAnticonvulsant drug effectsDoses of bicucullineBlood pressureCerebral perfusionSeizure dischargesPhosphorus nuclear magnetic resonance spectroscopyPhosphocreatine levelsParalyzed rabbitsBrain phosphocreatineDrug effectsNitrous oxide mixtureEpilepticusTriphosphate levelsVivo brainTwo-thirdsPhysiological variablesMagnetic resonance spectroscopyGradual declineIntracellular