1990
In Vivo Measurements of Ethanol Concentration in Rabbit Brain by 1H Magnetic Resonance Spectroscopy
Petroff O, Novotny E, Ogino T, Avison M, Prichard J. In Vivo Measurements of Ethanol Concentration in Rabbit Brain by 1H Magnetic Resonance Spectroscopy. Journal Of Neurochemistry 1990, 54: 1188-1195. PMID: 2313285, DOI: 10.1111/j.1471-4159.1990.tb01947.x.Peer-Reviewed Original ResearchConceptsMagnetic resonance spectroscopyResonance spectroscopyChemical Shift Selective Magnetic Resonance ImagingVivo 1H magnetic resonance spectroscopyCerebral blood flowBlood ethanol concentrationVivo 1H spectroscopyMagnetic resonance imagingIntragastric administrationBlood flowGas chromatographyRabbit brainResonance imagingSpectroscopyPerchloric acid extractsEthanol levelsAdministrationBrainAcid extractsVivo measurementsCerebralEthanol concentration
1989
High-field proton magnetic resonance spectroscopy of human cerebrum obtained during surgery for epilepsy.
Petroff O, Spencer D, Alger J, Prichard J. High-field proton magnetic resonance spectroscopy of human cerebrum obtained during surgery for epilepsy. Neurology 1989, 39: 1197-202. PMID: 2771071, DOI: 10.1212/wnl.39.9.1197.Peer-Reviewed Original ResearchConceptsProton magnetic resonance spectroscopyGamma-aminobutyric acidWhite matterTemporal lobe cortexHuman cerebrumHigh-field proton magnetic resonance spectroscopyBeta-hydroxybutyric acidConcentrations of creatineRefractory epilepsyN-acetylaspartateTemporal lobeMagnetic resonance spectroscopyPerchloric acid extractsSignificant differencesSurgeryEpilepsyCerebrumCreatineAcid extractsResonance spectroscopy
1988
Proton magnetic resonance spectroscopic studies of agonal carbohydrate metabolism in rabbit brain.
C. Petroff O, Prichard J, Ogino T, Shulman R. Proton magnetic resonance spectroscopic studies of agonal carbohydrate metabolism in rabbit brain. Neurology 1988, 38: 1569-74. PMID: 3419601, DOI: 10.1212/wnl.38.10.1569.Peer-Reviewed Original ResearchConceptsBlood glucoseCerebral lactate accumulationLactate accumulationProton magnetic resonance spectroscopic studyWet weight/minCerebral metabolismCardiac arrestControl rabbitsRabbit brainGlycolytic rateMagnetic resonance spectroscopic measurementsCarbohydrate metabolismEquivalents/RabbitsMagnetic resonance spectroscopyMetabolismGlucoseCarbohydrate availabilityGlucose equivalent/High‐Resolution Proton Magnetic Resonance Spectroscopy of Rabbit Brain: Regional Metabolite Levels and Postmortem Changes
Petroff O, Ogino T, Alger J. High‐Resolution Proton Magnetic Resonance Spectroscopy of Rabbit Brain: Regional Metabolite Levels and Postmortem Changes. Journal Of Neurochemistry 1988, 51: 163-171. PMID: 3379399, DOI: 10.1111/j.1471-4159.1988.tb04850.x.Peer-Reviewed Original ResearchConceptsN-acetylaspartateWhite matterRabbit cerebral cortexCerebral white matterProton magnetic resonance spectroscopyGamma-aminobutyric acidRegional metabolite levelsTotal creatine poolCardiac arrestCerebral cortexCerebral metabolitesRabbit brainMagnetic resonance spectroscopyCreatine poolMetabolite levelsReference standardPostmortem changesCortexResonance spectroscopyBiological 1H NMR spectroscopy
Petroff O. Biological 1H NMR spectroscopy. Comparative Biochemistry And Physiology Part B Comparative Biochemistry 1988, 90: 249-260. PMID: 3044689, DOI: 10.1016/0305-0491(88)90069-7.Peer-Reviewed Original ResearchConceptsProton nuclear magnetic resonance spectroscopyNuclear magnetic resonance spectroscopyRecent biological applicationsPowerful analytical methodMagnetic resonance spectroscopyNMR spectroscopyNMR methodsRate of metabolismBiological applicationsMetabolic fluxResonance spectroscopyChemical compoundsComplex mixturesAbnormal physiological conditionsNMRCompoundsSpectroscopyAnalytical methodPhysiological conditionsExogenous compoundsIntracellular pHBody fluidsMetabolismMetabolic pathophysiologyMagnetization transfer
1987
In vivo 31P and in vitro 1H nuclear magnetic resonance study of hypoglycemia during neonatal seizure
Young R, Cowan B, Petroff O, Novotny E, Dunham S, Briggs R. In vivo 31P and in vitro 1H nuclear magnetic resonance study of hypoglycemia during neonatal seizure. Annals Of Neurology 1987, 22: 622-628. PMID: 3426168, DOI: 10.1002/ana.410220511.Peer-Reviewed Original ResearchConceptsNeonatal seizuresBrain energy stateBicuculline-induced seizuresBrain glucose concentrationsCerebral blood flowBeta-hydroxybutyrate levelsBrain metabolic stateVivo 31P nuclear magnetic resonance spectroscopyBrain alanineAdenosine triphosphate levelsNeonatal dogsPhosphocreatine levelsSignificant elevationBlood flowSeizuresMagnetic resonance spectroscopyBrain extractsVivo 31PHypoglycemiaAdverse effectsTriphosphate levelsGlucose concentrationGreater declineFurther deteriorationMetabolic stateProton magnetic resonance spectroscopy of leech muscle and nervous system
Petroff O, Hogan E, Johansen J, Kleinhaus A. Proton magnetic resonance spectroscopy of leech muscle and nervous system. Comparative Biochemistry And Physiology Part B Comparative Biochemistry 1987, 87: 927-931. PMID: 3665438, DOI: 10.1016/0305-0491(87)90414-7.Peer-Reviewed Original ResearchConceptsMagnetic resonance spectroscopyProton nuclear magnetic resonance spectroscopyNuclear magnetic resonance spectroscopyResonance spectroscopyNMR spectroscopySpectroscopyMammalian cerebrumOrganic metabolitesIntracellular metabolitesNervous systemVentral cordPerchloric acid extractsMajor intracellular metaboliteSpectraNervous tissueAspartateAminobutyric acidRapid meansAcid extractsMetabolitesHirudonineInositolRabbit cerebrumAlanineDistinctive components
1986
High‐Resolution Proton Magnetic Resonance Analysis of Human Cerebrospinal Fluid
Petroff O, Yu R, Ogino T. High‐Resolution Proton Magnetic Resonance Analysis of Human Cerebrospinal Fluid. Journal Of Neurochemistry 1986, 47: 1270-1276. PMID: 3746301, DOI: 10.1111/j.1471-4159.1986.tb00750.x.Peer-Reviewed Original Research
1985
Cerebral intracellular pH by 31P nuclear magnetic resonance spectroscopy.
Petroff O, Prichard J, Behar K, Alger J, den Hollander J, Shulman R. Cerebral intracellular pH by 31P nuclear magnetic resonance spectroscopy. Neurology 1985, 35: 781-8. PMID: 4000479, DOI: 10.1212/wnl.35.6.781.Peer-Reviewed Original Research
1984
In vivo phosphorus nuclear magnetic resonance spectroscopy in status epilepticus
Petroff O, Prichard J, Behar K, Alger J, Shulman R. In vivo phosphorus nuclear magnetic resonance spectroscopy in status epilepticus. Annals Of Neurology 1984, 16: 169-177. PMID: 6476792, DOI: 10.1002/ana.410160203.Peer-Reviewed Original ResearchConceptsStatus epilepticusSeizure activityVivo phosphorus nuclear magnetic resonance spectroscopyControl valuesBicuculline-induced status epilepticusAdequate cerebral perfusionAnticonvulsant drug effectsDoses of bicucullineBlood pressureCerebral perfusionSeizure dischargesPhosphorus nuclear magnetic resonance spectroscopyPhosphocreatine levelsParalyzed rabbitsBrain phosphocreatineDrug effectsNitrous oxide mixtureEpilepticusTriphosphate levelsVivo brainTwo-thirdsPhysiological variablesMagnetic resonance spectroscopyGradual declineIntracellular