2023
Dickkopf1 Promotes Pulmonary Fibrosis upon Bleomycin-Induced Lung Injury
Sung E, Park M, Henegariu O, Sime P, Chae W. Dickkopf1 Promotes Pulmonary Fibrosis upon Bleomycin-Induced Lung Injury. American Journal Of Pathology 2023, 193: 1130-1142. PMID: 37263344, PMCID: PMC10477954, DOI: 10.1016/j.ajpath.2023.05.009.Peer-Reviewed Original ResearchConceptsLung injuryImmune cell infiltrationLung inflammationCell infiltrationCollagen depositionBleomycin-Induced Lung InjuryOrchestration of inflammationRole of DKK1Patient's lung tissueSmooth muscle actinGrowth factor-β1Myofibroblast marker αDKK1 protein expressionTissue repair processAntibody administrationPulmonary inflammationPulmonary fibrosisProfibrotic cytokinesDKK1 levelsAttractive molecular targetFibrosis modelLung tissueTissue injuryTissue fibrosisFactor-β1
2009
Receptor for advanced glycation end products is required for normal T cell activation and development of T cell induced lung inflammation (36.10)
Akirav E, Henegariu O, Clynes R, Schmidt A, Herold K. Receptor for advanced glycation end products is required for normal T cell activation and development of T cell induced lung inflammation (36.10). The Journal Of Immunology 2009, 182: 36.10-36.10. DOI: 10.4049/jimmunol.182.supp.36.10.Peer-Reviewed Original ResearchRAGE-/- miceT cell activationIntranasal OVA challengeT cellsOT-IICell activationNormal T cell activationOVA challengeRobust T cell infiltrationReduced T cell activationTranscription factor T-betAdvanced glycation end productsMediastinal lymph nodesT cell infiltrationOT-II miceGlycation end productsAdvanced glycation endproductsGATA-3 expressionIL5 productionCD62L expressionLung inflammationIFNγ expressionLymph nodesCellular infiltrateWT mice