2020
Neoantigen-based EpiGVAX vaccine initiates antitumor immunity in colorectal cancer
Kim VM, Pan X, Soares KC, Azad NS, Ahuja N, Gamper CJ, Blair AB, Muth S, Ding D, Ladle BH, Zheng L. Neoantigen-based EpiGVAX vaccine initiates antitumor immunity in colorectal cancer. JCI Insight 2020, 5: e136368. PMID: 32376802, PMCID: PMC7253020, DOI: 10.1172/jci.insight.136368.Peer-Reviewed Original ResearchConceptsMetastatic colorectal cancerColorectal cancerDNA methyltransferase inhibitorAntitumor efficacyAntigen-specific antitumor immune responsesAntitumor T-cell responsesCancer testis antigen expressionAntitumor immune responseT cell responsesAntitumor immunityCancer vaccinesSurvival outcomesCombination therapyAntigen expressionImmune responseMurine modelCTA expressionCell responsesNeoantigensImproved efficacyTumor cellsVaccineEfficacyGVAXMethyltransferase inhibitor
2017
Can echogenic appearance of neuroendocrine liver metastases on intraoperative ultrasonography predict tumor biology and prognosis?
Dogeas E, Chong CCN, Weiss MJ, Ahuja N, Choti MA. Can echogenic appearance of neuroendocrine liver metastases on intraoperative ultrasonography predict tumor biology and prognosis? Hepato Pancreato Biliary 2017, 20: 237-243. PMID: 29103839, DOI: 10.1016/j.hpb.2017.08.029.Peer-Reviewed Original ResearchConceptsNeuroendocrine liver metastasesTumor biologyLiver metastasesShorter median disease-free survivalMedian disease-free survivalDisease-free survivalManagement of patientsPotential prognostic factorsSmaller tumor sizeLong-term outcomesHypoechoic metastasesAdditional metastasesPrognostic factorsClinicopathologic factorsSurgical interventionSurgical strategyPreoperative imagingTumor sizeHypoechoic lesionsIntraoperative ultrasonographyNeuroendocrine tumorsProspective dataHyperechoic lesionsTumor gradeBiologic behavior
2013
Incidence and prognostic impact of KRAS and BRAF mutation in patients undergoing liver surgery for colorectal metastases
Karagkounis G, Torbenson MS, Daniel HD, Azad NS, Diaz LA, Donehower RC, Hirose K, Ahuja N, Pawlik TM, Choti MA. Incidence and prognostic impact of KRAS and BRAF mutation in patients undergoing liver surgery for colorectal metastases. Cancer 2013, 119: 4137-4144. PMID: 24104864, PMCID: PMC3967132, DOI: 10.1002/cncr.28347.Peer-Reviewed Original ResearchConceptsColorectal liver metastasesSurgical therapyBRAF mutationsLiver metastasesKRAS statusPrognostic impactKRAS mutationsMolecular biomarkersThird of patientsRecurrence-free survivalKRAS gene mutationsPrognostic determinantsColorectal metastasesSurgical cohortWorse survivalClinicopathologic factorsIndependent predictorsCancer surgeryClinicopathologic featuresTumor numberPrognostic significanceBRAF analysisColorectal cancerLiver surgeryLower incidence
2008
Retroperitoneal masses with associated human chorionic gonadotropin production: Report of two cases
Duffield AS, Jarrar P, Shum C, Ahuja N, Yeo CJ, Sokoll LJ. Retroperitoneal masses with associated human chorionic gonadotropin production: Report of two cases. Clinica Chimica Acta 2008, 395: 166-169. PMID: 18505680, DOI: 10.1016/j.cca.2008.04.030.Peer-Reviewed Original ResearchConceptsHuman chorionic gonadotropinSerum human chorionic gonadotropinSerum hCG concentrationsRetroperitoneal massHCG concentrationsEpidermoid cystHCG secretionHuman chorionic gonadotropin productionCancer antigen 19Course of diseaseChorionic gonadotropin productionBenign epidermoid cystPancreatic ductal adenocarcinomaPathologic examinationAntigen 19Gonadotropin productionCyst liningMalignant neoplasmsDisease progressionDuctal adenocarcinomaPancreatic adenocarcinomaImmunohistochemical stainingChorionic gonadotropinPatientsCysts