2016
Predictors of improved survival for patients with retroperitoneal sarcoma
Giuliano K, Nagarajan N, Canner JK, Wolfgang CL, Bivalacqua T, Terezakis S, Herman J, Schneider EB, Ahuja N. Predictors of improved survival for patients with retroperitoneal sarcoma. Surgery 2016, 160: 1628-1635. PMID: 27495850, DOI: 10.1016/j.surg.2016.05.041.Peer-Reviewed Original ResearchConceptsRetroperitoneal sarcomaMultivariable survival analysisSurvival analysisRetroperitoneal sarcoma patientsEnd Results (SEER) databaseOperative resectionImproved survivalLymph nodesSurvival benefitDistant metastasisHistologic typeResults databaseSarcoma patientsRare tumorCancer DatabaseLonger survivalPatientsSarcomaSurvivalParametric survival functionsLocal extensionFurther studiesHigh rateResectionRecurrence
2015
Survival Following Lung Metastasectomy in Soft Tissue Sarcomas
Giuliano K, Sachs T, Montgomery E, Guzzetta A, Brock M, Pawlik TM, Yang SC, Ahuja N. Survival Following Lung Metastasectomy in Soft Tissue Sarcomas. The Thoracic And Cardiovascular Surgeon 2015, 64: 150-158. PMID: 26339728, DOI: 10.1055/s-0035-1563538.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsAgedAged, 80 and overChildChild, PreschoolDisease-Free SurvivalFemaleHumansInfantKaplan-Meier EstimateLung NeoplasmsMaleMetastasectomyMiddle AgedNeoplasm GradingPneumonectomyRetrospective StudiesRisk FactorsSarcomaSoft Tissue NeoplasmsThoracoscopyTime FactorsTreatment OutcomeYoung AdultConceptsDisease-free intervalSoft tissue sarcomasLung metastasectomyTissue sarcomasLonger disease-free intervalLower pathologic gradeMedian overall survivalKaplan-Meier estimatesLog-rank testLow-grade tumorsGreatest survival advantageOverall survivalPostoperative factorsImproved survivalPatient selectionTumor characteristicsPathologic gradeMetastasis diagnosisCommon siteSurvival advantageSurvival analysisYounger ageMetastasectomyPatientsSurvival
2013
2564 resected periampullary adenocarcinomas at a single institution: trends over three decades
He J, Ahuja N, Makary MA, Cameron JL, Eckhauser FE, Choti MA, Hruban RH, Pawlik TM, Wolfgang CL. 2564 resected periampullary adenocarcinomas at a single institution: trends over three decades. Hepato Pancreato Biliary 2013, 16: 83-90. PMID: 23472829, PMCID: PMC3892319, DOI: 10.1111/hpb.12078.Peer-Reviewed Original ResearchConceptsPeriampullary adenocarcinomaBile ductSingle institutionPancreatic cancerIntraductal papillary mucinous neoplasmNumber of patientsPapillary mucinous neoplasmRelative survival ratesCurative intentWorse survivalLongterm outcomesMucinous neoplasmsSafe resectionLongterm survivalPathological diagnosisPrimary siteSurvival ratePancreaticoduodenectomyAdenocarcinomaPatientsSurvivalResectionSignificant differencesCancerDiagnosis
2012
Biomarkers for detection and prognosis of breast cancer identified by a functional hypermethylome screen
Jeschke J, Van Neste L, Glöckner SC, Dhir M, Calmon MF, Deregowski V, Van Criekinge W, Vlassenbroeck I, Koch A, Chan TA, Cope L, Hooker CM, Schuebel KE, Gabrielson E, Winterpacht A, Baylin SB, Herman JG, Ahuja N. Biomarkers for detection and prognosis of breast cancer identified by a functional hypermethylome screen. Epigenetics 2012, 7: 701-709. PMID: 22647880, DOI: 10.4161/epi.20445.Peer-Reviewed Original ResearchConceptsPoor overall survivalBreast cancerOverall survivalPrognosis predictionEffective biomarkersClinical prognostic variablesPrimary breast cancerDetection of BCFrequent methylated genesStrongest single markersSignificant prognosticatorBC patientsValidation cohortPrognostic variablesPrognostic signatureEarly detectionCancerBiomarkersPromoter hypermethylationMethylation changesTumor heterogeneityPrognosisSingle markerGene expression approachSurvival
2010
Disparity in limb-salvage surgery among sarcoma patients
Downing S, Ahuja N, Oyetunji TA, Chang D, Frederick WA. Disparity in limb-salvage surgery among sarcoma patients. The American Journal Of Surgery 2010, 199: 549-553. PMID: 20359572, DOI: 10.1016/j.amjsurg.2009.12.003.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAmputation, SurgicalAsianBlack or African AmericanFemaleHealth Services AccessibilityHealthcare DisparitiesHispanic or LatinoHumansLimb SalvageLogistic ModelsMaleMiddle AgedMultivariate AnalysisNeoadjuvant TherapyOdds RatioProportional Hazards ModelsRadiotherapy, AdjuvantSarcomaSEER ProgramUnited StatesWhite PeopleConceptsLimb-sparing proceduresLimb salvage surgeryLimb salvagePreoperative radiationSarcoma patientsAfrican AmericansEnd Results (SEER) databaseAfrican American patientsSpecific surgical proceduresWhite patientsResults databaseTreatment modalitiesAmerican patientsSurgical proceduresPatientsMultivariate analysisBivariate analysisLogistic regressionSalvageSurgerySurvivalRecent studiesPrevious studiesTumorsAmericans