2018
Automated diagnosis of colon cancer using hyperspectral sensing
Beaulieu RJ, Goldstein SD, Singh J, Safar B, Banerjee A, Ahuja N. Automated diagnosis of colon cancer using hyperspectral sensing. International Journal Of Medical Robotics And Computer Assisted Surgery 2018, 14: e1897. PMID: 29479794, DOI: 10.1002/rcs.1897.Peer-Reviewed Original ResearchConceptsColorectal cancerPossible metastatic diseaseColorectal cancer detectionColorectal cancer reliesMultiple tumor typesMetastatic diseaseOperative resectionSurgical resectionPathologic evaluationSurgical managementCancer reliesTumor specimensColon specimensColon cancerTumor typesPatient specimensCancerResectionPatientsDiagnostic methodsTumorsCancer detectionDiagnostic technologiesContrast agents
2013
DNA Methylation Biomarkers of Stool and Blood for Early Detection of Colon Cancer
Hong L, Ahuja N. DNA Methylation Biomarkers of Stool and Blood for Early Detection of Colon Cancer. Genetic Testing And Molecular Biomarkers 2013, 17: 401-406. PMID: 23406208, DOI: 10.1089/gtmb.2012.0478.Peer-Reviewed Original ResearchConceptsColon cancerDNA methylation markersEarly detectionMethylation markersStool-based testsCurrent screening testsScreening complianceColorectal cancerGeneral populationDNA methylation biomarkersClinical availabilityScreening testCancerClinical researchHigh efficacyBloodMethylation biomarkersStoolMarkersMore investigationEarly stagesColonoscopyPatientsMortalityDisease
2008
Is There a Difference in Survival Between Right- Versus Left-Sided Colon Cancers?
Meguid RA, Slidell MB, Wolfgang CL, Chang DC, Ahuja N. Is There a Difference in Survival Between Right- Versus Left-Sided Colon Cancers? Annals Of Surgical Oncology 2008, 15: 2388. PMID: 18622647, PMCID: PMC3072702, DOI: 10.1245/s10434-008-0015-y.Peer-Reviewed Original ResearchConceptsRight-sided colon cancerLeft-sided colon cancerProportional hazards regression analysisHazards regression analysisColon cancerMedian survivalCox proportional hazards regression analysisLongitudinal population-based databaseLong-term survival outcomesEnd Results Program databaseInvasive colon adenocarcinomaRight-sided cancersOverall median survivalLeft-sided cancersYear of diagnosisPopulation-based databaseRetrospective survival analysisSubset of subjectsRegression analysisSEER databaseSurgical resectionLymph nodesWorse prognosisSurvival outcomesTumor size
2006
Disparities in Colon Cancer Presentation and In-Hospital Mortality in Maryland: A Ten-Year Review
Ahuja N, Chang D, Gearhart SL. Disparities in Colon Cancer Presentation and In-Hospital Mortality in Maryland: A Ten-Year Review. Annals Of Surgical Oncology 2006, 14: 411-416. PMID: 17080235, DOI: 10.1245/s10434-006-9130-9.Peer-Reviewed Original ResearchConceptsLife-threatening symptomsHospital mortalityColon cancerSocioeconomic statusAfrican AmericansMaryland hospital discharge databaseColon cancer presentationHospital mortality rateIn-Hospital MortalityHospital discharge databaseColon cancer outcomesPrimary colon cancerColon cancer patientsHealth care accessOutcomes of interestTen-year reviewHigher socioeconomic statusConclusionsRacial disparitiesUnderwent resectionHospital outcomesCancer presentationSurgical resectionSymptomatic patientsPrehospital factorsPoor outcome
2001
Accelerated age-related CpG island methylation in ulcerative colitis.
Issa JP, Ahuja N, Toyota M, Bronner MP, Brentnall TA. Accelerated age-related CpG island methylation in ulcerative colitis. Cancer Research 2001, 61: 3573-7. PMID: 11325821.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAdultAge FactorsAgedCarrier ProteinsChondroitin Sulfate ProteoglycansColitis, UlcerativeColonic NeoplasmsCpG IslandsDNA MethylationGenes, p16HumansIntestinal MucosaLectins, C-TypeMiddle AgedMutL Protein Homolog 1MyoD ProteinNeoplasm ProteinsNuclear ProteinsPrecancerous ConditionsReceptors, EstrogenVersicansConceptsMechanism of geneP16 exon 1Exon 1CpG island hypermethylationCpG island methylationMethylation marksMethylation patternsUndesirable genesColorectal epithelial cellsIsland hypermethylationIsland methylationGenesMethylationPremature agingMyoDColon cancerHigh-grade dysplasiaEpithelial cellsCell turnoverHypermethylationNon-UC controlsNormal appearing epitheliumUlcerative colitisHigh levelsCSPG2
2000
Aging, methylation and cancer.
Ahuja N, Issa JP. Aging, methylation and cancer. Histology And Histopathology 2000, 15: 835-42. PMID: 10963127, DOI: 10.14670/hh-15.835.Peer-Reviewed Original ResearchConceptsAge-related methylationSuch age-related methylationPromoter-associated CpG islandsTumor suppressor geneGene functionDNA methylationCpG islandsMethylation changesFull methylationGene expressionMethylationGenesNovel targetNormal cellsColon cancerAlternate mechanismMost cancersEvidence pointsFundamental markMyoDIGF2HypermethylationDNAERMutations
1999
CpG island methylator phenotype in colorectal cancer
Toyota M, Ahuja N, Ohe-Toyota M, Herman J, Baylin S, Issa J. CpG island methylator phenotype in colorectal cancer. Proceedings Of The National Academy Of Sciences Of The United States Of America 1999, 96: 8681-8686. PMID: 10411935, PMCID: PMC17576, DOI: 10.1073/pnas.96.15.8681.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAge FactorsCarrier ProteinsCloning, MolecularColorectal NeoplasmsCpG IslandsDNA MethylationDNA RepairGenes, p16Genes, Tumor SuppressorHumansMicrosatellite RepeatsMutL Protein Homolog 1Neoplasm ProteinsNuclear ProteinsPhenotypePolymerase Chain ReactionSulfitesTumor Cells, CulturedConceptsCpG island methylator phenotypeColorectal cancerMethylator phenotypeSporadic colorectal cancerMismatch repair deficiencyCpG islandsAge-dependent mannerNormal colonic cellsCpG island amplificationHigh incidenceColon cancerTHBS1 methylationNormal colonPromoter region CpG islandsSporadic tumorsCancerMicrosatellite instabilityColonic cellsTumor suppressor geneCpG island methylationRepair deficiencyCancer-specific mannerHMLH1 methylationCell linesTranscriptional inactivation