2018
Trichuris muris whey acidic protein induces type 2 protective immunity against whipworm
Briggs N, Wei J, Versteeg L, Zhan B, Keegan B, Damania A, Pollet J, Hayes KS, Beaumier C, Seid CA, Leong J, Grencis RK, Bottazzi ME, Sastry KJ, Hotez PJ. Trichuris muris whey acidic protein induces type 2 protective immunity against whipworm. PLOS Pathogens 2018, 14: e1007273. PMID: 30153307, PMCID: PMC6130879, DOI: 10.1371/journal.ppat.1007273.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, HelminthAntigens, HelminthImmunityMaleMiceMice, Inbred AKRMice, KnockoutMice, SCIDMilk ProteinsTrichuriasisTrichurisVaccinationConceptsInflammatory bowel diseaseImmune correlatesLymph nodesProtective immunityT helper type 2 immune responseT. murisType 2 immune responsesIgE-mediated allergic responsesTh2 cytokines IL-4Adult T. murisAntigen-specific productionCellular immune correlatesHumoral immune correlatesMesenteric lymph nodesInguinal lymph nodesMontanide ISA 720Cytokines IL-4Control of infectionLow drug efficacySubcutaneous vaccineBowel diseaseInfectious causesOral challengeISA 720Protective efficacy
2017
Yeast-expressed recombinant As16 protects mice against Ascaris suum infection through induction of a Th2-skewed immune response
Wei J, Versteeg L, Liu Z, Keegan B, Gazzinelli-Guimarães AC, Fujiwara RT, Briggs N, Jones KM, Strych U, Beaumier CM, Bottazzi ME, Hotez PJ, Zhan B. Yeast-expressed recombinant As16 protects mice against Ascaris suum infection through induction of a Th2-skewed immune response. PLOS Neglected Tropical Diseases 2017, 11: e0005769. PMID: 28708895, PMCID: PMC5529013, DOI: 10.1371/journal.pntd.0005769.Peer-Reviewed Original ResearchConceptsTh2-skewed immune responseTh2-type responseCholera toxin B subunitImmune responseEgg challengeProtective immunitySignificant protectionPredominant Th2-type responseTh2-type immune responseFeasible vaccine candidateTh1-type responseCommon helminth infectionA. suum infectionAscaris suum infectionExact protective mechanismHost immune systemToxin B subunitA. suumRestimulated splenocytesA. suum eggsChallenge infectionIL-4IL-5Trichuris infectionHelminth infections