1998
T helper cell differentiation in multiple sclerosis and autoimmunity
Martin R, Ruddle N, Reingold S, Hafler D. T helper cell differentiation in multiple sclerosis and autoimmunity. Trends In Immunology 1998, 19: 495-498. PMID: 9818541, DOI: 10.1016/s0167-5699(98)01345-0.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoimmunityCell DifferentiationCytokinesHumansMultiple SclerosisT-Lymphocyte SubsetsT-Lymphocytes, Helper-Inducer
1993
T Helper 1 (TH1) Functional Phenotype of Human Myelin Basic Protein-Specific T Lymphocytes
Voskuhl R, Martin R, Bergman C, Dalal M, Ruddle N, Mcfarland H. T Helper 1 (TH1) Functional Phenotype of Human Myelin Basic Protein-Specific T Lymphocytes. Autoimmunity 1993, 15: 137-143. PMID: 7692995, DOI: 10.3109/08916939309043888.Peer-Reviewed Original ResearchConceptsExperimental allergic encephalomyelitisMyelin basic proteinMultiple sclerosisT cell linesT cellsMyelin basic protein-specific T lymphocytesMBP-specific T cell linesMurine experimental allergic encephalomyelitisMBP-specific T cellsAntigen-specific cytotoxic activityFunctional phenotypeEncephalitogenic T cellsHuman T cell lineCell linesTh1 subtypeCandidate autoantigenAllergic encephalomyelitisAutoimmune diseasesInflammatory cellsTumor necrosisT lymphocytesInterleukin-4Animal modelsImmunodominant regionCurrent report
1987
Suppressor cells induced by total lymphoid irradiation affect proliferation and lymphokine production of murine T helper cell clones
Mate T, Ruddle N. Suppressor cells induced by total lymphoid irradiation affect proliferation and lymphokine production of murine T helper cell clones. International Journal Of Radiation Oncology • Biology • Physics 1987, 13: 61-68. PMID: 2948938, DOI: 10.1016/0360-3016(87)90261-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFemaleImmunity, CellularInterferon-gammaInterleukin-2Lymphoid TissueLymphokinesLymphotoxin-alphaMiceMice, Inbred C57BLT-Lymphocytes, Helper-InducerT-Lymphocytes, RegulatoryConceptsTotal lymphoid irradiationT helper cell clonesSuppressor cellsInterleukin-2Lymphoid irradiationT-helper cell proliferative responsesCell clonesT cell capacityT cell growth factorHelper T cellsT cell populationsCell proliferative responsesMarked inhibitory effectGamma-IFN releaseLympho-reticular tissuesCell growth factorMurine T helper cell clonesNodal irradiationType hypersensitivityAntigen responseImmune suppressionImmunosuppressive effectsLymphokine responsesAntigen presentationT cells