2012
Characterization of Genome-Wide Association-Identified Variants for Atrial Fibrillation in African Americans
Delaney JT, Jeff JM, Brown NJ, Pretorius M, Okafor HE, Darbar D, Roden DM, Crawford DC. Characterization of Genome-Wide Association-Identified Variants for Atrial Fibrillation in African Americans. PLOS ONE 2012, 7: e32338. PMID: 22384221, PMCID: PMC3285683, DOI: 10.1371/journal.pone.0032338.Peer-Reviewed Original Research
2010
Genetic Variation in Soluble Epoxide Hydrolase (EPHX2) Is Associated With Forearm Vasodilator Responses in Humans
Lee CR, Pretorius M, Schuck RN, Burch LH, Bartlett J, Williams SM, Zeldin DC, Brown NJ. Genetic Variation in Soluble Epoxide Hydrolase (EPHX2) Is Associated With Forearm Vasodilator Responses in Humans. Hypertension 2010, 57: 116-122. PMID: 21098312, PMCID: PMC3020911, DOI: 10.1161/hypertensionaha.110.161695.Peer-Reviewed Original ResearchConceptsForearm blood flowVariant allele carriersForearm vasodilator responseForearm vascular resistanceSoluble epoxide hydrolaseVascular resistanceVasodilator responseBlood flowAllele carriersSodium nitroprussideVascular functionStrain-gauge venous occlusion plethysmographyHighest forearm blood flowLower forearm vascular resistanceSignificant associationCytochrome P450-derived epoxyeicosatrienoic acidsEpoxide hydrolaseVenous occlusion plethysmographyCardiovascular disease riskEndothelium-independent mannerWild-type individualsOcclusion plethysmographyPotent vasodilatorEpoxyeicosatrienoic acidsPreclinical models
2005
Prevalence of primary hyperaldosteronism in mild to moderate hypertension without hypokalaemia
Williams JS, Williams GH, Raji A, Jeunemaitre X, Brown NJ, Hopkins PN, Conlin PR. Prevalence of primary hyperaldosteronism in mild to moderate hypertension without hypokalaemia. Journal Of Human Hypertension 2005, 20: 129-136. PMID: 16292348, DOI: 10.1038/sj.jhh.1001948.Peer-Reviewed Original ResearchConceptsHigh sodium dietPrimary hyperaldosteronismModerate hypertensionSodium restrictionHypertensive populationLow serum potassium levelsNormotensive control populationSerum potassium levelsHigh blood pressureSpecific cutoff valuesElevated AERElevated ARRHaemodynamic testingNormotensive populationResistant hypertensionHypertensive subjectsNormotensive subjectsSerum aldosteroneBlood pressureEssential hypertensivesMedication washoutStudy protocolHypokalaemiaCutoff valueControl population
2004
Functional Variant of CYP4A11 20-Hydroxyeicosatetraenoic Acid Synthase Is Associated With Essential Hypertension
Gainer JV, Bellamine A, Dawson EP, Womble KE, Grant SW, Wang Y, Cupples LA, Guo CY, Demissie S, O’Donnell C, Brown NJ, Waterman MR, Capdevila JH. Functional Variant of CYP4A11 20-Hydroxyeicosatetraenoic Acid Synthase Is Associated With Essential Hypertension. Circulation 2004, 111: 63-69. PMID: 15611369, DOI: 10.1161/01.cir.0000151309.82473.59.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAllelesAmino Acid SubstitutionArachidonic AcidBlack PeopleBlood PressureCodonCohort StudiesComorbidityCytochrome P-450 CYP4ACytochrome P-450 Enzyme SystemDNA Mutational AnalysisFemaleGene FrequencyGenetic Predisposition to DiseaseGenetic VariationGenotypeHumansHydroxyeicosatetraenoic AcidsHypertensionIntronsKidneyLauric AcidsMaleMiddle AgedMultifactorial InheritanceMutagenesis, InsertionalMutation, MissensePoint MutationSequence DeletionTennesseeUnited StatesWhite PeopleConceptsArachidonic acidORs of hypertensionBlood pressure controlBody mass indexEndogenous arachidonic acidLarge population databaseFramingham Heart StudySevere hypertensionEssential hypertensionHypertension comorbidityTubular functionHypertensive statusMass indexFunctional variantsHypertensionHeart StudyPressure controlCYP4A11Polygenic determinantsPopulation databaseTargeted disruptionHuman CYP4A11Acid synthaseAssociationSynthase activity
2002
The relationship between plasma t‐PA and PAI‐1 levels is dependent on epistatic effects of the ACE I/D and PAI‐1 4G/5G polymorphisms
Moore J, Smolkin M, Lamb J, Brown N, Vaughan D. The relationship between plasma t‐PA and PAI‐1 levels is dependent on epistatic effects of the ACE I/D and PAI‐1 4G/5G polymorphisms. Clinical Genetics 2002, 62: 53-59. PMID: 12123488, DOI: 10.1034/j.1399-0004.2002.620107.x.Peer-Reviewed Original ResearchA comparison of combinatorial partitioning and linear regression for the detection of epistatic effects of the ACE I/D and PAI‐1 4G/5G polymorphisms on plasma PAI‐1 levels
Moore J, Lamb J, Brown N, Vaughan D. A comparison of combinatorial partitioning and linear regression for the detection of epistatic effects of the ACE I/D and PAI‐1 4G/5G polymorphisms on plasma PAI‐1 levels. Clinical Genetics 2002, 62: 74-79. PMID: 12123491, DOI: 10.1034/j.1399-0004.2002.620110.x.Peer-Reviewed Original ResearchEthnicity Affects Vasodilation, but Not Endothelial Tissue Plasminogen Activator Release, in Response to Bradykinin
Rosenbaum DA, Pretorius M, Gainer JV, Byrne D, Murphey LJ, Painter CA, Vaughan DE, Brown NJ. Ethnicity Affects Vasodilation, but Not Endothelial Tissue Plasminogen Activator Release, in Response to Bradykinin. Arteriosclerosis Thrombosis And Vascular Biology 2002, 22: 1023-1028. PMID: 12067915, DOI: 10.1161/01.atv.0000017704.45007.1d.Peer-Reviewed Original ResearchConceptsForearm blood flowFibrinolytic functionSodium nitroprussideEffect of ethnicityAge-matched normotensive subjectsTissue plasminogen activator antigenTissue plasminogen activator releaseDoses of bradykininPlasminogen activator antigenPlasminogen activator releaseFBF responseVasodilator responseNormotensive subjectsBrachial arteryIndependent agonistsArterial samplesBlood flowAntigen releaseActivator releaseBradykininMethacholineAcetylcholineWhite AmericansNitroprussideBlack Americans
2000
Altered frequency of a promoter polymorphism of the kinin B2 receptor gene in hypertensive African-Americans*
Gainer J, Brown N, Bachvarova M, Bastien L, Maltais I, Marceau F, Bachvarov D. Altered frequency of a promoter polymorphism of the kinin B2 receptor gene in hypertensive African-Americans*. American Journal Of Hypertension 2000, 13: 1268-1273. PMID: 11130770, DOI: 10.1016/s0895-7061(00)01215-2.Peer-Reviewed Original ResearchHuman β2‐adrenergic receptor polymorphisms: No association with essential hypertension in black or white Americans
Xie H, Stein C, Kim R, Gainer J, Sofowora G, Dishy V, Brown N, Goree R, Haines J, Wood A. Human β2‐adrenergic receptor polymorphisms: No association with essential hypertension in black or white Americans. Clinical Pharmacology & Therapeutics 2000, 67: 670-675. PMID: 10872649, DOI: 10.1067/mcp.2000.106293.Peer-Reviewed Original ResearchConceptsHypertensive subjectsEssential hypertensionGlu27 alleleBeta2-adrenergic receptor genotypesBeta2-adrenergic receptor polymorphismsWhite subjectsReceptor variantsBeta2-adrenergic receptor geneNormotensive white subjectsPresence of hypertensionBlack subjectsHomozygous genotypeBeta2-adrenergic receptorCommon genetic polymorphismsHypertensive groupNormotensive subjectsBlood pressurePopulation-based case-control association studiesVascular responsesCase-control association studyReceptor polymorphismsReceptor genotypeHypertensionReceptor responsesHuman beta2-adrenergic receptor
1999
α1A-Adrenergic receptor polymorphism
Xie H, Kim R, Stein C, Gainer J, Brown N, Wood A. α1A-Adrenergic receptor polymorphism. Pharmacogenetics And Genomics 1999, 9: 651-656. PMID: 10591546, DOI: 10.1097/00008571-199910000-00012.Peer-Reviewed Original ResearchConceptsAlpha1A-ARAfrican AmericansPrevalence of hypertensionPathogenesis of hypertensionAlpha1-adrenergic receptorsAlpha1-AR subtypesVascular smooth muscleCaucasian individualsEthnic differencesVasoconstrictor sensitivityVascular reactivityAlpha1-ARBlood pressureEssential hypertensionHypertensive individualsVascular responsesVascular toneReceptor polymorphismsSmooth muscleHypertensionSignificant intergenotypic differencesPotential roleRestriction fragment length polymorphismAllelic distributionFragment length polymorphismFrequency of functionally important beta-2 adrenoceptor polymorphisms varies markedly among African-American, Caucasian and Chinese individuals.
Xie HG, Stein CM, Kim RB, Xiao ZS, He N, Zhou HH, Gainer JV, Brown NJ, Haines JL, Wood AJ. Frequency of functionally important beta-2 adrenoceptor polymorphisms varies markedly among African-American, Caucasian and Chinese individuals. Pharmacogenetics And Genomics 1999, 9: 511-6. PMID: 10780271.Peer-Reviewed Original ResearchConceptsAfrican American individualsChinese individualsEthnic differencesSeverity of hypertensionDifferent ethnic groupsBeta-2 adrenergic receptorsMarked ethnic differencesEthnic groupsAdrenoceptor polymorphismsBAR agonistsGlu27 polymorphismGly16 alleleGlu27 alleleVascular responsesDisease manifestationsHealthy individualsAdrenergic receptorsCommon polymorphismsMarked interethnic differencesInterethnic differencesHomozygous genotypeGln27Arg16PolymorphismAlterations
1997
Angiotensin II type I Receptor polymorphism in African Americans lower frequency of the C1166 variant
Gainer J, Hunley T, Kon V, Nadeau J, Muldowney J, Brown N. Angiotensin II type I Receptor polymorphism in African Americans lower frequency of the C1166 variant. IUBMB Life 1997, 43: 227-231. PMID: 9315301, DOI: 10.1080/15216549700204001.Peer-Reviewed Original ResearchConceptsC1166 variantAngiotensin II type I receptorAfrican AmericansNormotensive African AmericansType I receptorReceptor polymorphismsAfrican American populationCaucasian subjectsI receptorSubstitution polymorphismCaucasiansAmerican populationHypertensionLow frequencyPolymorphismAmericansVariantsReceptors
1996
Black Americans have an increased rate of angiotensin converting enzyme inhibitor‐associated angioedema
Brown N, Ray W, Snowden M, Griffin M. Black Americans have an increased rate of angiotensin converting enzyme inhibitor‐associated angioedema. Clinical Pharmacology & Therapeutics 1996, 60: 8-13. PMID: 8689816, DOI: 10.1016/s0009-9236(96)90161-7.Peer-Reviewed Original ResearchConceptsACE inhibitor useEnzyme (ACE) inhibitor-associated angioedemaInhibitor useACE inhibitorsRelative riskWhite subjectsACE inhibitor-associated angioedemaACE inhibitor doseRate of angiotensinRetrospective cohort studyRisk of angioedemaTennessee Medicaid programAssociation of racePotential confounding factorsEffect of doseSpecific ACE inhibitorDiuretic useCohort studyConcurrent medicationsPatient characteristicsPrevious hospitalizationAngioedemaInhibitor doseConfounding factorsYears of use