2006
Bradykinin and Its Metabolite Bradykinin 1-5 Inhibit Thrombin-Induced Platelet Aggregation in Humans
Murphey LJ, Malave HA, Petro J, Biaggioni I, Byrne DW, Vaughan DE, Luther JM, Pretorius M, Brown NJ. Bradykinin and Its Metabolite Bradykinin 1-5 Inhibit Thrombin-Induced Platelet Aggregation in Humans. Journal Of Pharmacology And Experimental Therapeutics 2006, 318: 1287-1292. PMID: 16772538, DOI: 10.1124/jpet.106.104026.Peer-Reviewed Original ResearchConceptsForearm blood flowNet t-PA releaseT-PA releaseThrombin-induced platelet aggregationPlatelet aggregationBradykinin 1Thrombin receptor-activating peptide-induced platelet aggregationTissue plasminogen activator antigenMajor stable metabolitePeptide-induced platelet aggregationDoses of bradykininThrombin receptor-activating peptideAntecubital venous bloodPlasminogen activator antigenArterial plasma samplesDose-dependent increaseGamma-thrombinReceptor-activating peptidePlatelet-rich plasmaPmol/minPeptide infusionBrachial arteryVenous bloodHealthy subjectsBlood flow
2004
The Preparation and Characterization of Novel Peptide Antagonists to Thrombin and Factor VIIa and Activation of Protease-Activated Receptor 1
Nieman MT, Warnock M, Hasan AA, Mahdi F, Lucchesi BR, Brown NJ, Murphey LJ, Schmaier AH. The Preparation and Characterization of Novel Peptide Antagonists to Thrombin and Factor VIIa and Activation of Protease-Activated Receptor 1. Journal Of Pharmacology And Experimental Therapeutics 2004, 311: 492-501. PMID: 15210836, DOI: 10.1124/jpet.104.069229.Peer-Reviewed Original Research