2020
Skeletal Muscle Mitochondrial Dysfunction Is Present in Patients with CKD before Initiation of Maintenance Hemodialysis
Gamboa JL, Roshanravan B, Towse T, Keller CA, Falck AM, Yu C, Frontera WR, Brown NJ, Ikizler TA. Skeletal Muscle Mitochondrial Dysfunction Is Present in Patients with CKD before Initiation of Maintenance Hemodialysis. Clinical Journal Of The American Society Of Nephrology 2020, 15: 926-936. PMID: 32591419, PMCID: PMC7341789, DOI: 10.2215/cjn.10320819.Peer-Reviewed Original ResearchMeSH KeywordsAdipose TissueAdultAgedDynaminsFemaleGlomerular Filtration RateHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMaleMiddle AgedMitochondriaMuscle StrengthPhosphocreatinePhysical Functional PerformanceQuadriceps MuscleRenal DialysisRenal Insufficiency, ChronicSeverity of Illness IndexWalk TestConceptsMaintenance hemodialysisMarkers of inflammationAdipose tissue infiltrationOxidative stressPhysical performanceMitochondrial dysfunctionTissue infiltrationMitochondrial functionSkeletal muscle mitochondrial dysfunctionCKD stage 3Poor physical performanceSeverity of CKDMuscle mitochondrial dysfunctionIntermuscular adipose tissueSkeletal muscle biopsiesMagnetic resonance imagingWalk testHigh morbidityPhysical functionPhosphocreatine recoveryMultifactorial etiologyMuscle biopsyCKDHemodialysisPatients
2016
Mitochondrial dysfunction and oxidative stress in patients with chronic kidney disease
Gamboa JL, Billings FT, Bojanowski MT, Gilliam LA, Yu C, Roshanravan B, Roberts LJ, Himmelfarb J, Ikizler TA, Brown NJ. Mitochondrial dysfunction and oxidative stress in patients with chronic kidney disease. Physiological Reports 2016, 4: e12780. PMID: 27162261, PMCID: PMC4873632, DOI: 10.14814/phy2.12780.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseCKD stage 5Peripheral blood mononuclear cellsSeverity of CKDCKD stage 3Kidney diseaseOxidative stressF2-isoprostanesMtDNA copy numberMuscle biopsyMitochondrial volume densitySkeletal muscleDifferent CKD stagesMitochondrial dysfunctionBlood mononuclear cellsStage 3Stage 5Skeletal muscle biopsiesLower mtDNA copy numberMitochondrial DNA copy numberPlasma isofuransCKD stageMuscle dysfunctionMononuclear cellsFunction worsens