Comparative effects of immediate‐release and extended‐release aspirin on basal and bradykinin‐stimulated excretion of thromboxane and prostacyclin metabolites
Gamboa JL, Devin JK, Ramirez CE, Yu C, Nian H, Lee RH, Brown NJ. Comparative effects of immediate‐release and extended‐release aspirin on basal and bradykinin‐stimulated excretion of thromboxane and prostacyclin metabolites. Pharmacology Research & Perspectives 2016, 4: e00221. PMID: 27069632, PMCID: PMC4804312, DOI: 10.1002/prp2.221.Peer-Reviewed Original ResearchProstacyclin metaboliteThromboxane productionProstacyclin productionBasal excretionDoses of ASAImmediate-release aspirinStable prostacyclin metaboliteBasal urinary excretionInhibition of basalAspirin therapyIntravenous bradykininASA groupThromboxane metabolitesUrinary excretionEndothelial productionTreatment periodHealthy subjectsCrossover designThromboxane formationAspirinPlatelet aggregationExcretionProstacyclinThromboxaneFifth day