2000
Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism Modulates the Human In Vivo Metabolism of Bradykinin
Murphey L, Gainer J, Vaughan D, Brown N. Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism Modulates the Human In Vivo Metabolism of Bradykinin. Circulation 2000, 102: 829-832. PMID: 10952948, DOI: 10.1161/01.cir.102.8.829.Peer-Reviewed Original ResearchConceptsPlasma ACE activityACE activityInsertion/deletion polymorphismD genotypeD alleleBK1-5ACE I/D polymorphismEnzyme insertion/deletion polymorphismAngiotensin-Converting Enzyme Insertion/Deletion PolymorphismTissue plasminogen activator releaseAngiotensin II productionDeletion polymorphismTissue ACE activityACE D alleleACE I/IPlasminogen activator releaseFmol/mLPlasma ACE levelsBradykinin metabolismBrachial arteryVenous returnCardioprotective peptideKinin concentrationsACE levelsBradykinin concentrations
1998
ACE Insertion/Deletion Genotype Affects Bradykinin Metabolism
Brown N, Blais C, Gandhi S, Adam A. ACE Insertion/Deletion Genotype Affects Bradykinin Metabolism. Journal Of Cardiovascular Pharmacology 1998, 32: 373-377. PMID: 9733349, DOI: 10.1097/00005344-199809000-00006.Peer-Reviewed Original ResearchConceptsSerum ACE activityAng IIACE activityPlasma Ang II concentrationACE insertion/deletion genotypeACE deletion alleleAng I infusionAng II concentrationsDeleterious cardiovascular effectsACE D alleleInsertion/deletion genotypeSignificant inverse relationACE deletionCardiovascular morbidityCardiovascular effectsI infusionAng IACE genotypeACE levelsACE DDBradykinin degradationAngiotensin ID alleleSynthetic bradykininDeletion allele