2024
Toxic Nephropathies of the Tubulointerstitium: Core Curriculum 2024
Krishnan N, Moledina D, Perazella M. Toxic Nephropathies of the Tubulointerstitium: Core Curriculum 2024. American Journal Of Kidney Diseases 2024, 83: 659-676. PMID: 38243994, DOI: 10.1053/j.ajkd.2023.09.017.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsRenal injurySeverity of renal injuryToxic nephropathyTubulointerstitial renal injuryIrreversible renal injuryToxin-induced renal injuryImmune response genesNephrotoxic riskClinical presentationTubulointerstitial injuryRenal functionClinical manifestationsPatient characteristicsTubular secretionGlomerular filtrationComorbid conditionsMetabolic handlingDrug metabolismExcretory pathwayInjuryTransport defectAdverse effectsTubulointerstitiumNephropathyExogenous toxins
2022
Should Corticosteroids Be Used to Treat Biopsy-Proven Drug-Induced Acute Interstitial Nephritis?: PRO
Donati A, Krishnan N. Should Corticosteroids Be Used to Treat Biopsy-Proven Drug-Induced Acute Interstitial Nephritis?: PRO. Kidney360 2022, 3: 1306-1309. PMID: 36176666, PMCID: PMC9416830, DOI: 10.34067/kid.0006642021.Peer-Reviewed Original Research
2021
Pathogenesis and Treatment of Refractory Oedema in Nephrotic Syndrome
Jethwani P, Krishnan N. Pathogenesis and Treatment of Refractory Oedema in Nephrotic Syndrome. EMJ Urology 2021, 9: 107-117. DOI: 10.33590/emjurol/21-00041.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsEffective arterial blood volumeNephrotic syndromeArterial blood volumeSodium retentionEdema formationLoop diureticsRefractory edemaClinical trialsBlood volumeSodium-potassium adenosine triphosphatase activityCombination diuretic therapySalt-poor albuminSecondary sodium retentionMainstay of therapySubset of patientsLarge clinical trialsSignificant patient morbidityVasopressin receptor antagonistsEpithelial sodium channel activationLimited available evidenceDiuretic resistanceDiuretic therapySodium channel activationTreatment algorithmInflammation contributes
2020
Assessment of Faculty Developed e-Curriculum in Hemodialysis
Krishnan N. Assessment of Faculty Developed e-Curriculum in Hemodialysis. Journal Of The American Society Of Nephrology 2020, 31: 448-448. DOI: 10.1681/asn.20203110s1448a.Peer-Reviewed Original Research
2015
Drug-induced acute interstitial nephritis: pathology, pathogenesis, and treatment.
Krishnan N, Perazella MA. Drug-induced acute interstitial nephritis: pathology, pathogenesis, and treatment. Iranian Journal Of Kidney Diseases 2015, 9: 3-13. PMID: 25599729.BooksConceptsDrug-induced acute interstitial nephritisCell-mediated immune injuryLess chronic kidney diseaseAcute interstitial nephritisHallmark pathologic featureIncomplete renal recoveryInterstitial dendritic cellsNeo-antigen formationPredominance of CD4Acute kidney injurySerum creatinine levelsChronic kidney diseaseMainstay of treatmentRenal tubular epithelial cellsUse of steroidsDuration of injuryTubular epithelial cellsRenal recoveryChronic dialysisKidney injuryCreatinine levelsImmunologic injuryInterstitial inflammationDendritic cellsImmune injury
2008
Monozygotic transplantation: concerns and opportunities.
Krishnan N, Buchanan PM, Dzebisashvili N, Xiao H, Schnitzler MA, Brennan DC. Monozygotic transplantation: concerns and opportunities. American Journal Of Transplantation : Official Journal Of The American Society Of Transplantation And The American Society Of Transplant Surgeons 2008, 8: 2343-51. PMID: 18808409, PMCID: PMC2678894, DOI: 10.1111/j.1600-6143.2008.02378.x.Peer-Reviewed Original ResearchA Mutation in the Mouse Chd2 Chromatin Remodeling Enzyme Results in a Complex Renal Phenotype
Marfella CG, Henninger N, LeBlanc SE, Krishnan N, Garlick DS, Holzman LB, Imbalzano AN. A Mutation in the Mouse Chd2 Chromatin Remodeling Enzyme Results in a Complex Renal Phenotype. Kidney & Blood Pressure Research 2008, 31: 421-432. PMID: 19142019, PMCID: PMC2818461, DOI: 10.1159/000190788.Peer-Reviewed Original ResearchConceptsChd2 proteinATP-dependent chromatin remodelingChromodomain helicase DNA-binding protein 2DNA-binding protein 2Family of enzymesChromatin remodelingChromatin structureEpigenetic regulatorsGlomerular diseaseGene expressionMolecular mechanismsKidney functionProtein 2Enzyme resultsDiverse groupProteinNew insightsMutationsRenal phenotypeKidney failureGlomerular functionHematocrit levelsNew moleculesSerum analysisMiceAcute Renal Faiure in the Intensive Care Unit
Krishnan N, 2008. Acute Renal Failure in the Intensive Care Unit. In Manual of Intensive Care Medicine, 5th edition. Lippincott Williams and Wilkins. pp: 392 to 397Books
2007
Metabolic Acid Base Disorders.
Chawla (Krishnan) N, Koch M. 2007. In Washington University Manual of Critical Care. 1st edition, Lippincott Williams and Wilkins, pp. 179-189.Books