2022
Mitochondrial Dysfunction, Mitophagy and Their Correlation with Perinatal Complications: Preeclampsia and Low Birth Weight
Yildirim R, Ergun Y, Basar M. Mitochondrial Dysfunction, Mitophagy and Their Correlation with Perinatal Complications: Preeclampsia and Low Birth Weight. Biomedicines 2022, 10: 2539. PMID: 36289801, PMCID: PMC9599185, DOI: 10.3390/biomedicines10102539.Peer-Reviewed Original ResearchLow birth weightBirth weightProgression of preeclampsiaFetal growthPerinatal complicationsFetal mortalityPlacental implantationPrenatal complicationsMitochondrial dysfunctionPreeclampsiaPathophysiologyReactive oxygen speciesReceptor-mediated mitophagyComplicationsMitochondrial quality control mechanismsAccumulation of damaged mitochondriaDysfunctionAccumulation of reactive oxygen speciesDouble-membrane vesiclesCellular survivalQuality control mechanismsAutophagy of mitochondriaPathologyOxygen speciesMitochondrial network
2010
The Implication of Aberrant GM-CSF Expression in Decidual Cells in the Pathogenesis of Preeclampsia
Huang SJ, Zenclussen AC, Chen CP, Basar M, Yang H, Arcuri F, Li M, Kocamaz E, Buchwalder L, Rahman M, Kayisli U, Schatz F, Toti P, Lockwood CJ. The Implication of Aberrant GM-CSF Expression in Decidual Cells in the Pathogenesis of Preeclampsia. American Journal Of Pathology 2010, 177: 2472-2482. PMID: 20829438, PMCID: PMC2966804, DOI: 10.2353/ajpath.2010.091247.Peer-Reviewed Original ResearchConceptsGranulocyte-macrophage colony-stimulating factorColony-stimulating factorPathogenesis of preeclampsiaDendritic cellsDecidual cellsFirst trimester human decidual cellsGranulocyte-macrophage colony-stimulating factor (GM-CSF) expressionGenesis of preeclampsiaSystemic inflammatory stateInterleukin-1 βTumor necrosis factorHuman decidual cellsColony-stimulating factor expressionFactor expression levelsColony-stimulating factor productionGM-CSF expressionGranulocyte-macrophage colony-stimulating factor productionPreeclamptic deciduaShallow placentationInflammatory stateHuman deciduaNecrosis factorMurine modelPreeclampsiaMouse modelPreeclampsia-related increase of interleukin-11 expression in human decidual cells
Basar M, Yen CF, Buchwalder LF, Murk W, Huang SJ, Godlewski K, Kocamaz E, Arda O, Schatz F, Lockwood CJ, Kayisli UA. Preeclampsia-related increase of interleukin-11 expression in human decidual cells. Reproduction 2010, 140: 605-612. PMID: 20668109, PMCID: PMC3795512, DOI: 10.1530/rep-10-0263.Peer-Reviewed Original ResearchMeSH KeywordsAdultDeciduaEstradiolFemaleHumansImidazolesImmunohistochemistryInterleukin-11Interleukin-1betaNaphthalenesNF-kappa BP38 Mitogen-Activated Protein KinasesPre-EclampsiaPregnancyProtein Kinase CPyridinesReverse Transcriptase Polymerase Chain ReactionRNA, MessengerStatistics, NonparametricTumor Necrosis Factor-alphaConceptsFirst trimester decidual cellsDecidual cellsPlacental sectionsLeukocyte-free first trimester decidual cellsGestational age-matched controlsProtein kinase CMaternal-placental interfaceUteroplacental blood flowPathogenesis of preeclampsiaAnti-inflammatory processesCultured decidual cellsTumor necrosis factorAge-matched controlsHuman decidual cellsQuantitative RT-PCRSystemic inflammationNecrosis factorPreeclampsiaBlood flowP38 MAP kinaseIL11 expressionNuclear factorStimulatory effectIL11RT-PCR