2010
The Implication of Aberrant GM-CSF Expression in Decidual Cells in the Pathogenesis of Preeclampsia
Huang SJ, Zenclussen AC, Chen CP, Basar M, Yang H, Arcuri F, Li M, Kocamaz E, Buchwalder L, Rahman M, Kayisli U, Schatz F, Toti P, Lockwood CJ. The Implication of Aberrant GM-CSF Expression in Decidual Cells in the Pathogenesis of Preeclampsia. American Journal Of Pathology 2010, 177: 2472-2482. PMID: 20829438, PMCID: PMC2966804, DOI: 10.2353/ajpath.2010.091247.Peer-Reviewed Original ResearchConceptsGranulocyte-macrophage colony-stimulating factorColony-stimulating factorPathogenesis of preeclampsiaDendritic cellsDecidual cellsFirst trimester human decidual cellsGranulocyte-macrophage colony-stimulating factor (GM-CSF) expressionGenesis of preeclampsiaSystemic inflammatory stateInterleukin-1 βTumor necrosis factorHuman decidual cellsColony-stimulating factor expressionFactor expression levelsColony-stimulating factor productionGM-CSF expressionGranulocyte-macrophage colony-stimulating factor productionPreeclamptic deciduaShallow placentationInflammatory stateHuman deciduaNecrosis factorMurine modelPreeclampsiaMouse model
2008
Preeclampsia-Related Inflammatory Cytokines Regulate Interleukin-6 Expression in Human Decidual Cells
Lockwood CJ, Yen CF, Basar M, Kayisli UA, Martel M, Buhimschi I, Buhimschi C, Huang SJ, Krikun G, Schatz F. Preeclampsia-Related Inflammatory Cytokines Regulate Interleukin-6 Expression in Human Decidual Cells. American Journal Of Pathology 2008, 172: 1571-1579. PMID: 18467705, PMCID: PMC2408417, DOI: 10.2353/ajpath.2008.070629.Peer-Reviewed Original ResearchConceptsIL-6 levelsIL-6Decidual cellsGestational age-matched control placentasElevated IL-6 levelsIL-6 mRNA levelsCommon pregnancy disorderGenesis of preeclampsiaUteroplacental blood flowFetal-placental unitInterleukin-6 levelsPathogenesis of preeclampsiaPro-inflammatory cytokinesEndothelial cell dysfunctionInterleukin-6 expressionHuman decidual cellsReal-time quantitative RT-PCRTime quantitative RT-PCRQuantitative RT-PCRFetal morbidityDecidual macrophagesPreeclamptic womenSystemic inflammationPregnancy disordersControl placentas