2019
Assessing the interactions between radiotherapy and antitumour immunity
Grassberger C, Ellsworth S, Wilks M, Keane F, Loeffler J. Assessing the interactions between radiotherapy and antitumour immunity. Nature Reviews Clinical Oncology 2019, 16: 729-745. PMID: 31243334, DOI: 10.1038/s41571-019-0238-9.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsCheckpoint inhibitorsIntroduction of immune checkpoint inhibitorsTherapy-induced immune responsesLong-term tumor controlImmune responsePre-existing immune responsesImmune response to radiotherapyInteraction of immunotherapyResponse to radiotherapyAdvanced-stage diseaseRadiation-induced immunosuppressionImmune cell dynamicsSite of diseaseIndividualized treatment approachPatient levelAntitumour immunityRadiotherapy regimensTumor controlTreatment of cancerIncrease response ratesRadiotherapyImmunotherapySerum biomarkersClinical data
2015
Heat‐Induced Radiolabeling of Nanoparticles for Monocyte Tracking by PET
Normandin M, Yuan H, Wilks M, Chen H, Kinsella J, Cho H, Guehl N, Absi‐Halabi N, Hosseini S, Fakhri G, Sosnovik D, Josephson L. Heat‐Induced Radiolabeling of Nanoparticles for Monocyte Tracking by PET. Angewandte Chemie 2015, 127: 13194-13198. DOI: 10.1002/ange.201505525.Peer-Reviewed Original ResearchPositron emission tomographyRadiolabelling of nanoparticlesStandardized uptake valueMonocytes in vitroNP pharmacokineticsSlow uptake processUptake valueLymph nodesCirculating monocytesMonocyte traffickingIV injectionImmune responseBlood clearanceEmission tomographyHepatic uptakeMonocytesPharmacokineticsLymphUptake processHeat‐Induced Radiolabeling of Nanoparticles for Monocyte Tracking by PET
Normandin M, Yuan H, Wilks M, Chen H, Kinsella J, Cho H, Guehl N, Absi‐Halabi N, Hosseini S, Fakhri G, Sosnovik D, Josephson L. Heat‐Induced Radiolabeling of Nanoparticles for Monocyte Tracking by PET. Angewandte Chemie International Edition 2015, 54: 13002-13006. PMID: 26368132, PMCID: PMC4754124, DOI: 10.1002/anie.201505525.Peer-Reviewed Original ResearchConceptsPositron emission tomographyRadiolabelling of nanoparticlesStandardized uptake valueNP pharmacokineticsSlow uptake processUptake valueLymph nodesCirculating monocytesMonocyte traffickingIV injectionImmune responseBlood clearanceEmission tomographyHepatic uptakeMonocytesPharmacokineticsLymphUptake processCytometry