2021
Epigenetic age acceleration, fatigue, and inflammation in patients undergoing radiation therapy for head and neck cancer: A longitudinal study
Xiao C, Beitler JJ, Peng G, Levine ME, Conneely KN, Zhao H, Felger JC, Wommack EC, Chico CE, Jeon S, Higgins KA, Shin DM, Saba NF, Burtness BA, Bruner DW, Miller AH. Epigenetic age acceleration, fatigue, and inflammation in patients undergoing radiation therapy for head and neck cancer: A longitudinal study. Cancer 2021, 127: 3361-3371. PMID: 34027995, DOI: 10.1002/cncr.33641.Peer-Reviewed Original ResearchConceptsC-reactive proteinIL-6 levelsEpigenetic age accelerationNeck cancerInterleukin-6Inflammatory markersHigher epigenetic age accelerationLower C-reactive proteinAge accelerationHigher C-reactive proteinMultidimensional Fatigue Inventory-20Poor functional outcomeBlood DNA methylationMonths postradiotherapyAdvanced diseaseConcurrent chemoradiationMost patientsDistant metastasisFunctional outcomeSevere fatigueTreatment completionRadiation therapyPatientsGreater fatigueInflammation
2012
The role of physiological markers of health in the association between demographic factors and periodontal disease
Levine ME, Kim JK, Crimmins EM. The role of physiological markers of health in the association between demographic factors and periodontal disease. Journal Of Periodontal Research 2012, 48: 367-372. PMID: 23231345, PMCID: PMC3609891, DOI: 10.1111/jre.12016.Peer-Reviewed Original ResearchConceptsC-reactive proteinPeriodontal diseaseRace/ethnicitySocio-economic statusDemographic factorsOral health statusMultiple physiological systemsSystemic healthOral diseasesMeasures of SESHigh prevalencePhysiological measuresHealth statusSocio-demographic variablesLogistic regressionDiseaseCytomegalovirusElevated levelsAssociationEarly agingLow-income individualsPhysiological markersBiomarkersDemographic variablesHealthThe Impact of Insulin Resistance and Inflammation on the Association Between Sarcopenic Obesity and Physical Functioning
Levine ME, Crimmins EM. The Impact of Insulin Resistance and Inflammation on the Association Between Sarcopenic Obesity and Physical Functioning. Obesity 2012, 20: 2101-2106. PMID: 22310233, PMCID: PMC3527629, DOI: 10.1038/oby.2012.20.Peer-Reviewed Original ResearchConceptsDual-energy X-ray absorptiometryC-reactive proteinInsulin resistancePhysical functioningSarcopenic obesityPhysical functioning problemsMuscle massDifferent body composition phenotypesSerum C-reactive proteinAppendicular skeletal muscle massHomeostasis model assessmentNutrition Examination SurveyCross-sectional studyX-ray absorptiometryBody composition categoriesSkeletal muscle massBody composition phenotypesBody composition measurementsPoisson regression modelsRace/ethnicityNonsarcopenic obesitySarcopenic nonobeseSarcopenic nonobesitySarcopenic obeseSystemic inflammation