2020
Gastroesophageal Reflux
Masoud A, Hinchcliff M. Gastroesophageal Reflux. In Clinical Practice 2020, 179-191. DOI: 10.1007/978-3-030-53736-4_16.Peer-Reviewed Original ResearchGastroesophageal refluxSystemic sclerosisGastric antral vascular ectasia (GAVE) syndromePatient-reported health-related qualityRheumatism 2013 classification criteriaRheumatology/European LeagueSmall bowel bacterial overgrowthMajor underlying pathologyHealth-related qualitySmooth muscle atrophyControl of refluxBowel bacterial overgrowthLower esophageal sphincterOptimal patient carePharyngeal symptomsAspiration pneumonitisFecal incontinencePeptic strictureAggressive preventionBacterial overgrowthGastric emptyingEsophageal sphincterUnderlying pathologyBarrett's esophagusEsophageal adenocarcinoma
2017
A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis
Taroni JN, Greene CS, Martyanov V, Wood TA, Christmann RB, Farber HW, Lafyatis RA, Denton CP, Hinchcliff ME, Pioli PA, Mahoney JM, Whitfield ML. A novel multi-network approach reveals tissue-specific cellular modulators of fibrosis in systemic sclerosis. Genome Medicine 2017, 9: 27. PMID: 28330499, PMCID: PMC5363043, DOI: 10.1186/s13073-017-0417-1.Peer-Reviewed Original ResearchConceptsDisease-associated signaturesFunctional genomic networksGene expression signaturesPulmonary fibrosisAutoimmune diseasesDisease processMulti-organ autoimmune diseaseDistinct underlying pathologyPro-fibrotic macrophagesInternal organ involvementPulmonary arterial hypertensionExpression signaturesSkin of patientsInnate immune systemWilcoxon rank sum testGenomic networksRank sum testBackgroundSystemic sclerosisArterial hypertensionOrgan involvementSystemic sclerosisUnderlying pathologyLung microenvironmentSkin fibrosisFibrotic genes