2022
Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation
Cai WL, Chen JF, Chen H, Wingrove E, Kurley SJ, Chan LH, Zhang M, Arnal-Estape A, Zhao M, Balabaki A, Li W, Yu X, Krop ED, Dou Y, Liu Y, Jin J, Westbrook TF, Nguyen DX, Yan Q. Human WDR5 promotes breast cancer growth and metastasis via KMT2-independent translation regulation. ELife 2022, 11: e78163. PMID: 36043466, PMCID: PMC9584608, DOI: 10.7554/elife.78163.Peer-Reviewed Original ResearchConceptsBreast cancer cellsMetastatic breast cancerBreast cancerRibosomal gene expressionCancer cellsKnockdown of WDR5Vivo genetic screenReversible epigenetic mechanismsGenetic screenTranslation regulationTriple-negative breast cancerEpigenetic regulatorsEpigenetic mechanismsBreast cancer growthCancer-related deathTranslation efficiencyWDR5Novel therapeutic strategiesTranslation rateGene expressionCell growthAdvanced diseaseEffective therapyMetastatic capabilityPotent suppression
2019
Adaptive Protein Translation by the Integrated Stress Response Maintains the Proliferative and Migratory Capacity of Lung Adenocarcinoma Cells
Albert AE, Adua SJ, Cai WL, Arnal-Estapé A, Cline GW, Liu Z, Zhao M, Cao PD, Mariappan M, Nguyen DX. Adaptive Protein Translation by the Integrated Stress Response Maintains the Proliferative and Migratory Capacity of Lung Adenocarcinoma Cells. Molecular Cancer Research 2019, 17: 2343-2355. PMID: 31551255, PMCID: PMC6938689, DOI: 10.1158/1541-7786.mcr-19-0245.Peer-Reviewed Original ResearchMeSH KeywordsActivating Transcription Factor 4Adenocarcinoma of LungAmino AcidsCarbon-Nitrogen Ligases with Glutamine as Amide-N-DonorCell Line, TumorCell ProliferationCyclin B1Eukaryotic Initiation Factor-2Gene Expression Regulation, NeoplasticHumansNF-E2-Related Factor 2Oxidative StressPhosphatidylinositol 3-KinasesProtein BiosynthesisProteostasisSignal TransductionStress, PhysiologicalTOR Serine-Threonine KinasesConceptsIntegrated stress responseProtein translationCell cycle progressionLung adenocarcinoma cellsLung cancer cellsNew regulatory layerCertain oncogenic mutationsAmino acid limitationNovel regulatory mechanismControl of proteostasisCancer cellsDifferent biological consequencesEIF2α-dependent mannerAmino acid metabolismAdenocarcinoma cellsNrf2 protein levelsPI3K pathwayConserved pathwayRegulatory layerISR pathwayATF4 branchCell cycle regulator cyclin B1MTOR/PI3K pathwaySelect proteinsAsparagine synthetase
2014
Histone Demethylase RBP2 Is Critical for Breast Cancer Progression and Metastasis
Cao J, Liu Z, Cheung WK, Zhao M, Chen SY, Chan SW, Booth CJ, Nguyen DX, Yan Q. Histone Demethylase RBP2 Is Critical for Breast Cancer Progression and Metastasis. Cell Reports 2014, 6: 868-877. PMID: 24582965, PMCID: PMC4014129, DOI: 10.1016/j.celrep.2014.02.004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBreast NeoplasmsCell Line, TumorDisease ProgressionEpigenesis, GeneticFemaleGene Expression Regulation, NeoplasticHistone DemethylasesHumansMaleMammary Neoplasms, ExperimentalMiceMice, Inbred NODMice, SCIDMice, TransgenicNeoplasm MetastasisRetinol-Binding Proteins, CellularTransfectionConceptsHistone demethylase RBP2MMTV-neu transgenic miceHuman breast cancer cellsMajor clinical challengeBreast cancer metastasisBreast cancer progressionBreast cancer cellsClinical challengeBreast cancer gene expression data setsTherapeutic targetingTransgenic miceMetastasisMetastatic progressionPutative mediatorsTumor progressionCancer metastasisCancer treatmentCancer progressionTumor metastasisTumor formationCancer cellsProgressionAberrant epigenetic modificationsMetastasis genesMice