2023
Markerless head motion tracking and event-by-event correction in brain PET
Zeng T, Lu Y, Jiang W, Zheng J, Zhang J, Gravel P, Wan Q, Fontaine K, Mulnix T, Jiang Y, Yang Z, Revilla E, Naganawa M, Toyonaga T, Henry S, Zhang X, Cao T, Hu L, Carson R. Markerless head motion tracking and event-by-event correction in brain PET. Physics In Medicine And Biology 2023, 68: 245019. PMID: 37983915, PMCID: PMC10713921, DOI: 10.1088/1361-6560/ad0e37.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsBrainHeadHumansImage Processing, Computer-AssistedMotionMovementPhantoms, ImagingPositron-Emission TomographyConceptsPoint source studyHead motion correctionSmaller residual displacementMotion correctionIterative closest point (ICP) registration algorithmHead motion trackingSpatial resolutionResidual displacementData-driven evaluation methodHigh spatial resolutionLow noiseMotion trackingStereovision cameraMotion tracking deviceStructured lightEvent correctionBrain positron emission tomography (PET) imagingTracking deviceReconstruction resultsHMT methodPoint cloudsNegative biasReference cloudUMTEvaluation methodDose reduction in dynamic synaptic vesicle glycoprotein 2A PET imaging using artificial neural networks
Li A, Yang B, Naganawa M, Fontaine K, Toyonaga T, Carson R, Tang J. Dose reduction in dynamic synaptic vesicle glycoprotein 2A PET imaging using artificial neural networks. Physics In Medicine And Biology 2023, 68: 245006. PMID: 37857316, PMCID: PMC10739622, DOI: 10.1088/1361-6560/ad0535.Peer-Reviewed Original ResearchMeSH KeywordsBrainDrug TaperingGlycoproteinsHumansImage Processing, Computer-AssistedNeural Networks, ComputerPositron-Emission TomographySynaptic Vesicles
2022
Adaptive data-driven motion detection and optimized correction for brain PET
Revilla EM, Gallezot JD, Naganawa M, Toyonaga T, Fontaine K, Mulnix T, Onofrey JA, Carson RE, Lu Y. Adaptive data-driven motion detection and optimized correction for brain PET. NeuroImage 2022, 252: 119031. PMID: 35257856, PMCID: PMC9206767, DOI: 10.1016/j.neuroimage.2022.119031.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsBrainHumansImage Processing, Computer-AssistedKineticsMotionMovementPositron-Emission TomographyConceptsDetection algorithmMotion correction methodMotion tracking informationExternal motion tracking devicesMotion detection algorithmMotion tracking methodImage registration algorithmHead motionReal human datasetsData-driven methodUser-defined parametersImage quality degradationMotion tracking deviceMultiple usersDynamic datasetsTracking informationManual interventionRegistration algorithmMotion detectionTracking methodComparable performanceAlgorithmQuality degradationHuman datasetsTracking device
2021
Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's disease
Lu Y, Toyonaga T, Naganawa M, Gallezot JD, Chen MK, Mecca AP, van Dyck CH, Carson RE. Partial volume correction analysis for 11C-UCB-J PET studies of Alzheimer's disease. NeuroImage 2021, 238: 118248. PMID: 34119639, PMCID: PMC8454285, DOI: 10.1016/j.neuroimage.2021.118248.Peer-Reviewed Original ResearchAlzheimer DiseaseBrainCerebrovascular CirculationHumansImage Processing, Computer-AssistedPositron-Emission TomographyRadiopharmaceuticals
2020
Simplified Quantification of 11C-UCB-J PET Evaluated in a Large Human Cohort
Naganawa M, Gallezot JD, Finnema SJ, Matuskey D, Mecca A, Nabulsi NB, Labaree D, Ropchan J, Malison RT, D'Souza DC, Esterlis I, Detyniecki K, van Dyck CH, Huang Y, Carson RE. Simplified Quantification of 11C-UCB-J PET Evaluated in a Large Human Cohort. Journal Of Nuclear Medicine 2020, 62: 418-421. PMID: 32646875, PMCID: PMC8049341, DOI: 10.2967/jnumed.120.243949.Peer-Reviewed Original ResearchCase-Control StudiesFemaleHumansImage Processing, Computer-AssistedMaleMental DisordersMiddle AgedPositron-Emission TomographyPyridinesPyrrolidinonesData-Driven Motion Detection and Event-by-Event Correction for Brain PET: Comparison with Vicra
Lu Y, Naganawa M, Toyonaga T, Gallezot JD, Fontaine K, Ren S, Revilla EM, Mulnix T, Carson RE. Data-Driven Motion Detection and Event-by-Event Correction for Brain PET: Comparison with Vicra. Journal Of Nuclear Medicine 2020, 61: 1397-1403. PMID: 32005770, PMCID: PMC7456171, DOI: 10.2967/jnumed.119.235515.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsBrainHumansImage Processing, Computer-AssistedMovementPositron-Emission TomographyConceptsData-driven algorithmMotion correction methodMotion tracking informationHead motionCentroid of distributionMotion-compensated reconstructionLarge head motionsMotion correction frameworkUser-defined thresholdPET raw dataDynamic datasetsTracking informationImage registrationMotion detectionRaw dataSuch time pointsImage qualityBetter performanceMotion correctionAlgorithmLine of responseCorrection frameworkBrain PET studiesCentral coordinatesTracer kinetic modeling
2019
Assessment of a white matter reference region for 11C-UCB-J PET quantification
Rossano S, Toyonaga T, Finnema SJ, Naganawa M, Lu Y, Nabulsi N, Ropchan J, De Bruyn S, Otoul C, Stockis A, Nicolas JM, Martin P, Mercier J, Huang Y, Maguire RP, Carson RE. Assessment of a white matter reference region for 11C-UCB-J PET quantification. Cerebrovascular And Brain Metabolism Reviews 2019, 40: 1890-1901. PMID: 31570041, PMCID: PMC7446568, DOI: 10.1177/0271678x19879230.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAlgorithmsBrainFemaleHumansImage Processing, Computer-AssistedLevetiracetamMaleMembrane GlycoproteinsMiddle AgedNerve Tissue ProteinsPositron-Emission TomographyRadiopharmaceuticalsReference StandardsWhite MatterData-driven voluntary body motion detection and non-rigid event-by-event correction for static and dynamic PET
Lu Y, Gallezot JD, Naganawa M, Ren S, Fontaine K, Wu J, Onofrey JA, Toyonaga T, Boutagy N, Mulnix T, Panin VY, Casey ME, Carson RE, Liu C. Data-driven voluntary body motion detection and non-rigid event-by-event correction for static and dynamic PET. Physics In Medicine And Biology 2019, 64: 065002. PMID: 30695768, DOI: 10.1088/1361-6560/ab02c2.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsAnimalsDogsFluorodeoxyglucose F18HaplorhiniHumansImage Processing, Computer-AssistedMonitoring, PhysiologicMovementOrgan MotionPositron-Emission TomographyRespirationRespiratory-Gated Imaging TechniquesConceptsCentroid of distribution
2016
Event-by-Event Continuous Respiratory Motion Correction for Dynamic PET Imaging
Yu Y, Chan C, Ma T, Liu Y, Gallezot JD, Naganawa M, Kelada OJ, Germino M, Sinusas AJ, Carson RE, Liu C. Event-by-Event Continuous Respiratory Motion Correction for Dynamic PET Imaging. Journal Of Nuclear Medicine 2016, 57: 1084-1090. PMID: 26912437, DOI: 10.2967/jnumed.115.167676.Peer-Reviewed Original Research
2015
Test–Retest Reproducibility of Binding Parameters in Humans with 11C-LY2795050, an Antagonist PET Radiotracer for the κ Opioid Receptor
Naganawa M, Zheng MQ, Henry S, Nabulsi N, Lin SF, Ropchan J, Labaree D, Najafzadeh S, Kapinos M, Tauscher J, Neumeister A, Carson RE, Huang Y. Test–Retest Reproducibility of Binding Parameters in Humans with 11C-LY2795050, an Antagonist PET Radiotracer for the κ Opioid Receptor. Journal Of Nuclear Medicine 2015, 56: 243-248. PMID: 25593119, PMCID: PMC4322754, DOI: 10.2967/jnumed.114.147975.Peer-Reviewed Original ResearchConceptsTest-retest variabilityOpioid receptorsOutcome measuresAbsolute test-retest variabilityMultilinear analysis 1Healthy human subjectsSuitable reference regionTest-retest reproducibilityIntraclass correlation coefficientAntagonist radiotracersHealthy subjectsLY2795050PET scansBrain regionsDistribution volumePET radioligandTest-retest performancePET studiesArterial input functionPET radiotracersHuman subjectsReference regionReceptorsVT valuesKOR
2013
Event‐by‐event respiratory motion correction for PET with 3D internal‐1D external motion correlation
Chan C, Jin X, Fung EK, Naganawa M, Mulnix T, Carson RE, Liu C. Event‐by‐event respiratory motion correction for PET with 3D internal‐1D external motion correlation. Medical Physics 2013, 40: 112507. PMID: 24320466, DOI: 10.1118/1.4826165.Peer-Reviewed Original ResearchMeSH KeywordsCarcinoma, Non-Small-Cell LungFluorine RadioisotopesHealthy VolunteersHumansHypoxiaImage Processing, Computer-AssistedImaging, Three-DimensionalInsulin-Secreting CellsKidneyLung NeoplasmsMisonidazoleMovementPancreasPositron-Emission TomographyRegression AnalysisReproducibility of ResultsRespirationSignal Processing, Computer-AssistedTetrabenazineX-Ray Microtomography
2009
A new graphic plot analysis for determination of neuroreceptor binding in positron emission tomography studies
Ito H, Yokoi T, Ikoma Y, Shidahara M, Seki C, Naganawa M, Takahashi H, Takano H, Kimura Y, Ichise M, Suhara T. A new graphic plot analysis for determination of neuroreceptor binding in positron emission tomography studies. NeuroImage 2009, 49: 578-586. PMID: 19631754, DOI: 10.1016/j.neuroimage.2009.07.021.Peer-Reviewed Original Research
2008
Shortened protocol in practical [11C]SA4503-PET studies for sigma1 receptor quantification
Sakata M, Kimura Y, Naganawa M, Ishikawa M, Oda K, Ishii K, Hashimoto K, Chihara K, Ishiwata K. Shortened protocol in practical [11C]SA4503-PET studies for sigma1 receptor quantification. Annals Of Nuclear Medicine 2008, 22: 143-146. PMID: 18311540, DOI: 10.1007/s12149-007-0088-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain ChemistryBrain MappingCarbon RadioisotopesClinical ProtocolsFluvoxamineHumansImage Interpretation, Computer-AssistedImage Processing, Computer-AssistedIsotope LabelingMaleParoxetinePiperazinesPositron-Emission TomographyRadioligand AssayRadiopharmaceuticalsReceptors, sigmaSelective Serotonin Reuptake InhibitorsTissue DistributionConceptsTotal distribution volumePET scansSelective serotonin reuptake inhibitorsSerotonin reuptake inhibitorsReuptake inhibitorsHealthy subjectsLogan plot analysisReceptor measurementsTomography diagnosisTime-activity curvesBrain disordersDistribution volumePET studiesReceptor quantificationTissue time-activity curvesScansCompartmental analysisFull-length protocolsPositron Emission Tomography DiagnosisPatientsPlot analysisRegion of interestProtocolDiagnosisAdministration
2007
Robust estimation of the arterial input function for Logan plots using an intersectional searching algorithm and clustering in positron emission tomography for neuroreceptor imaging
Naganawa M, Kimura Y, Yano J, Mishina M, Yanagisawa M, Ishii K, Oda K, Ishiwata K. Robust estimation of the arterial input function for Logan plots using an intersectional searching algorithm and clustering in positron emission tomography for neuroreceptor imaging. NeuroImage 2007, 40: 26-34. PMID: 18187345, DOI: 10.1016/j.neuroimage.2007.11.035.Peer-Reviewed Original ResearchDistribution volume as an alternative to the binding potential for sigma1 receptor imaging
Kimura Y, Naganawa M, Sakata M, Ishikawa M, Mishina M, Oda K, Ishii K, Ishiwata K. Distribution volume as an alternative to the binding potential for sigma1 receptor imaging. Annals Of Nuclear Medicine 2007, 21: 533-535. PMID: 18030587, DOI: 10.1007/s12149-007-0063-6.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnatomy, RegionalBrainBrain MappingCarbon RadioisotopesData Interpretation, StatisticalFemaleHumansImage Processing, Computer-AssistedMaleMiddle AgedNonlinear DynamicsPiperazinesPositron-Emission TomographyRadioligand AssayRadiopharmaceuticalsReceptors, sigmaReference StandardsConceptsPositron emission tomographyDistribution volumeTotal distribution volumeReference regionReceptor densityClinical investigationReceptor imagingSigma1 receptorsEmission tomographyAppropriate reference regionReceptorsTarget receptorsPhysiological situationsNeuroreceptor mappingHigh affinityImagingDVTDiseaseRadioligandBrainPET kinetic analysis: wavelet denoising of dynamic PET data with application to parametric imaging
Shidahara M, Ikoma Y, Kershaw J, Kimura Y, Naganawa M, Watabe H. PET kinetic analysis: wavelet denoising of dynamic PET data with application to parametric imaging. Annals Of Nuclear Medicine 2007, 21: 379. PMID: 17876550, DOI: 10.1007/s12149-007-0044-9.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsAlgorithmsAnimalsArtifactsBrain MappingCluster AnalysisComputer SimulationCoronary CirculationFourier AnalysisHumansImage EnhancementImage Interpretation, Computer-AssistedImage Processing, Computer-AssistedKineticsNonlinear DynamicsNuclear MedicinePositron-Emission TomographyRadiopharmaceuticalsSoftwareTime FactorsEvaluation of distribution of adenosine A2A receptors in normal human brain measured with [11C]TMSX PET
Mishina M, Ishiwata K, Kimura Y, Naganawa M, Oda K, Kobayashi S, Katayama Y, Ishii K. Evaluation of distribution of adenosine A2A receptors in normal human brain measured with [11C]TMSX PET. Synapse 2007, 61: 778-784. PMID: 17568431, DOI: 10.1002/syn.20423.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrainBrain MappingCarbon RadioisotopesHumansImage Processing, Computer-AssistedKineticsMagnetic Resonance ImagingMalePositron-Emission TomographyReceptor, Adenosine A2ATime FactorsTissue DistributionXanthinesConceptsPositron emission tomographyPosterior putamenCaudate nucleusFrontal lobeHuman brainPromising PET ligandSelective A2AR antagonistNormal male subjectsMetabolite-corrected plasmaPosterior cingulate gyrusAdenosine A2A receptorsNormal human brainCerebral cortexA2AR antagonistCingulate gyrusArterial bloodOccipital lobeParkinson's diseaseTemporal lobePET scansA2A receptorsThree-compartment modelParietal lobePET ligandMale subjectsMapping of human cerebral sigma1 receptors using positron emission tomography and [11C]SA4503
Sakata M, Kimura Y, Naganawa M, Oda K, Ishii K, Chihara K, Ishiwata K. Mapping of human cerebral sigma1 receptors using positron emission tomography and [11C]SA4503. NeuroImage 2007, 35: 1-8. PMID: 17240168, DOI: 10.1016/j.neuroimage.2006.11.055.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiotransformationBrainBrain ChemistryBrain MappingChromatography, High Pressure LiquidData Interpretation, StatisticalDopamine AntagonistsHaloperidolHumansImage Processing, Computer-AssistedMaleNonlinear DynamicsPiperazinesPositron-Emission TomographyRadioligand AssayRadiopharmaceuticalsReceptors, sigmaConceptsTotal distribution volumePositron emission tomographyEmission tomographyMetabolite correctionHealthy male subjectsSigma receptor antagonistLogan plotHuman brainPlasma input functionReceptor antagonistOral administrationClinical studiesPET scansThree-compartment modelPartial blockadePsychiatric diseasesMale subjectsSigma1RSigma1 receptorsBaseline measurementsDistribution volumeTwo-tissueHaloperidolBrainReceptors
2006
Quantification of adenosine A2A receptors in the human brain using [11C]TMSX and positron emission tomography
Naganawa M, Kimura Y, Mishina M, Manabe Y, Chihara K, Oda K, Ishii K, Ishiwata K. Quantification of adenosine A2A receptors in the human brain using [11C]TMSX and positron emission tomography. European Journal Of Nuclear Medicine And Molecular Imaging 2006, 34: 679-687. PMID: 17171358, DOI: 10.1007/s00259-006-0294-0.Peer-Reviewed Original Research
2005
MAP-based kinetic analysis for voxel-by-voxel compartment model estimation: Detailed imaging of the cerebral glucose metabolism using FDG
Kimura Y, Naganawa M, Yamaguchi J, Takabayashi Y, Uchiyama A, Oda K, Ishii K, Ishiwata K. MAP-based kinetic analysis for voxel-by-voxel compartment model estimation: Detailed imaging of the cerebral glucose metabolism using FDG. NeuroImage 2005, 29: 1203-1211. PMID: 16216532, DOI: 10.1016/j.neuroimage.2005.08.046.Peer-Reviewed Original ResearchAlgorithmsBlood GlucoseBrainBrain MappingComputer GraphicsComputer SimulationEnergy MetabolismFluorodeoxyglucose F18HumansImage Processing, Computer-AssistedImaging, Three-DimensionalKineticsLeast-Squares AnalysisNonlinear DynamicsPhantoms, ImagingPositron-Emission TomographyReproducibility of Results