2005
Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance
Oppenheim DE, Roberts SJ, Clarke SL, Filler R, Lewis JM, Tigelaar RE, Girardi M, Hayday AC. Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance. Nature Immunology 2005, 6: 928-937. PMID: 16116470, DOI: 10.1038/ni1239.Peer-Reviewed Original ResearchMeSH Keywords9,10-Dimethyl-1,2-benzanthraceneAnimalsCarcinomaCell Line, TumorDisease SusceptibilityDown-RegulationFemaleImmunologic SurveillanceKiller Cells, NaturalLigandsMaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicNK Cell Lectin-Like Receptor Subfamily KPapillomaReceptors, ImmunologicReceptors, Natural Killer CellSkin NeoplasmsTetradecanoylphorbol AcetateT-LymphocytesTumor BurdenConceptsNKG2D downregulationNK cell-mediated cytotoxicityNatural killer cellsCell-mediated cytotoxicityInnate immune activationT cell defectsNKG2D engagementNatural cytotoxicityKiller cellsImmune activationReceptor NKG2DTumor immunosurveillanceCutaneous carcinogenesisTumor surveillanceT cellsReversible defectsRAE-1Normal epitheliumLigand expressionTumor resistanceCell defectsSustained expressionNKG2DImmunosurveillanceDownregulation
2003
The Distinct Contributions of Murine T Cell Receptor (TCR)γδ+ and TCRαβ+ T Cells to Different Stages of Chemically Induced Skin Cancer
Girardi M, Glusac E, Filler RB, Roberts SJ, Propperova I, Lewis J, Tigelaar RE, Hayday AC. The Distinct Contributions of Murine T Cell Receptor (TCR)γδ+ and TCRαβ+ T Cells to Different Stages of Chemically Induced Skin Cancer. Journal Of Experimental Medicine 2003, 198: 747-755. PMID: 12953094, PMCID: PMC2194182, DOI: 10.1084/jem.20021282.Peer-Reviewed Original ResearchMeSH Keywords9,10-Dimethyl-1,2-benzanthraceneAnimalsCarcinogensDisease Models, AnimalHematopoietic Stem CellsLiverMiceMice, KnockoutNeoplasm StagingPapillomaReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaSkin NeoplasmsTetradecanoylphorbol AcetateTime FactorsT-LymphocytesConceptsAlphabeta T cellsT cellsT cell receptorGammadelta cellsCell receptorProgression of papillomasResident intraepithelial lymphocytesSquamous cell carcinomaT-cell typeTwo-stage regimenMurine T cell receptorInduction of papillomasIntraepithelial lymphocytesCutaneous malignanciesCell carcinomaFVB miceHost protectionSkin cancerLow dosesCarcinomaPapillomasTumor promoterNonredundant contributionsModifier genesProgression
2002
Resident Skin-specific γδ T Cells Provide Local, Nonredundant Regulation of Cutaneous Inflammation
Girardi M, Lewis J, Glusac E, Filler RB, Geng L, Hayday AC, Tigelaar RE. Resident Skin-specific γδ T Cells Provide Local, Nonredundant Regulation of Cutaneous Inflammation. Journal Of Experimental Medicine 2002, 195: 855-867. PMID: 11927630, PMCID: PMC2193718, DOI: 10.1084/jem.20012000.Peer-Reviewed Original ResearchConceptsT cell receptorEpidermal T cellsT cellsIrritant dermatitisGammadelta T-cell receptorT cell-mediated inflammationCell-mediated inflammationSystemic inflammatory reactionIrritant contact dermatitis reactionsΓδ T cellsGammadelta T cellsContact dermatitis reactionsCutaneous inflammationIEL subsetsChronic dermatitisFunctional impairmentInflammatory reactionDermatitis reactionsEpithelial interfaceCell subpopulationsCell receptorMiceMouse strainsDermatitisSingle autosomal recessive gene