1997
Mucosal Protection from Intestinal Ischemia–Reperfusion Reduces Oxidant Injury to the Lung
Rossman J, Caty M, Zheng S, Karamanoukian H, Thusu K, Azizkhan R, Dandona P. Mucosal Protection from Intestinal Ischemia–Reperfusion Reduces Oxidant Injury to the Lung. Journal Of Surgical Research 1997, 73: 41-46. PMID: 9441791, DOI: 10.1006/jsre.1997.5196.Peer-Reviewed Original ResearchConceptsIntestinal mucosal injuryLung injuryMucosal injuryOxygenated perfluorocarbonLipid peroxidationDistant organ injuryIntestinal ischemia reperfusionLung lipid peroxidationPortal venous circulationPortal venous effluentOrgan injuryIschemia reperfusionMucosal protectionPortal bloodVenous effluentVenous circulationLung tissueLuminal perfusionIntraluminal oxygenOxidant injurySmall intestineInjuryOxidant generationReactive oxygen speciesPrimary effectorOxygenated intraluminal perfluorocarbon protects intestinal muscosa from ischemia/reperfusion injury
O'Donnell K, Caty M, Zheng S, Rossman J, Azizkhan R. Oxygenated intraluminal perfluorocarbon protects intestinal muscosa from ischemia/reperfusion injury. Journal Of Pediatric Surgery 1997, 32: 361-365. PMID: 9044154, DOI: 10.1016/s0022-3468(97)90211-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFluorocarbonsIntestinal MucosaIntestinesIschemiaMaleOxygenRatsRats, Sprague-DawleyReperfusion InjuryConceptsIschemia/reperfusion injurySuperior mesenteric arteryMucosal injuryReperfusion injuryMucosal integrityOxygenated perfluorocarbonNew treatment modalitiesR groupMesenteric insufficiencyR injuryMesenteric arteryMucosal functionTreatment modalitiesIntraluminal perfusionMucosal preservationIschemic disordersRat modelIntraluminal flowIntestinal mucosaClinical situationsInjuryIschemiaTissue sectionsReperfusionFeasible technique
1996
Neutrophil activation and chemotaxis after in vitro treatment with perfluorocarbon
Rossman J, Caty M, Rich G, Karamanoukian H, Azizkhan R. Neutrophil activation and chemotaxis after in vitro treatment with perfluorocarbon. Journal Of Pediatric Surgery 1996, 31: 1147-1151. PMID: 8863252, DOI: 10.1016/s0022-3468(96)90105-0.Peer-Reviewed Original ResearchConceptsNeutrophil activationNeutrophil samplesHuman neutrophil activationEffects of perfluorocarbonLower chemotactic responseFilter migrationFlow cytometryControl valuesControl fluorescenceNeutrophilsChemotactic responseActivation studiesActivationChemotaxisChemotaxis studiesDetectable H2O2PerfluorocarbonCytometry