2018
Chapter 17 Managing a Child With OCD Who Is Treatment Refractory
Bloch M. Chapter 17 Managing a Child With OCD Who Is Treatment Refractory. 2018, 329-356. DOI: 10.1016/b978-0-12-811427-8.00017-4.Peer-Reviewed Original ResearchObsessive-compulsive disorderTreatment-refractory obsessive-compulsive disorderCognitive behavioral therapyFirst-line treatmentOCD symptomsPediatric obsessive-compulsive disorderSelective serotonin reuptake inhibitor (SSRI) pharmacotherapyEffective first-line treatmentSelective serotonin reuptake inhibitorsIntensive treatment programSerotonin reuptake inhibitorsGlutamate-modulating agentsMajority of childrenTreatment programAntipsychotic augmentationReuptake inhibitorsTreatment refractoryPharmacological treatmentAvailable treatmentsChildrenSubstantial proportionPharmacotherapyTreatmentTherapySymptoms
2016
Commentary: Are alpha‐2 agonist really effective in children with tics with comorbid ADHD? A commentary on Whittington et al. (2016)
Bloch MH. Commentary: Are alpha‐2 agonist really effective in children with tics with comorbid ADHD? A commentary on Whittington et al. (2016). Journal Of Child Psychology And Psychiatry 2016, 57: 1005-1007. PMID: 27535650, DOI: 10.1111/jcpp.12592.Peer-Reviewed Original ResearchConceptsAlpha-2 agonistsComorbid ADHDComprehensive Behavioral InterventionAdrenergic receptor agonistAgonist medicationsAntipsychotic medicationReceptor agonistPrimary treatmentTic disordersSystematic reviewMedicationsBehavioral interventionsAgonistsEffects of ADHDEfficacyTreatmentADHDChildrenPossible explanationPatients
2015
Meta-Analysis: Reduced Risk of Anxiety with Psychostimulant Treatment in Children with Attention-Deficit/Hyperactivity Disorder
Coughlin CG, Cohen SC, Mulqueen JM, Ferracioli-Oda E, Stuckelman ZD, Bloch MH. Meta-Analysis: Reduced Risk of Anxiety with Psychostimulant Treatment in Children with Attention-Deficit/Hyperactivity Disorder. Journal Of Child And Adolescent Psychopharmacology 2015, 25: 611-617. PMID: 26402485, PMCID: PMC4617411, DOI: 10.1089/cap.2015.0075.Peer-Reviewed Original ResearchConceptsRisk of anxietyAttention-deficit/hyperactivity disorderPsychostimulant treatmentSide effectsHyperactivity disorderPlacebo-controlled trialStratified subgroup analysisTreatment of childrenDuration of useRisk ratioSubgroup analysisPsychostimulant medicationPlaceboPubMed searchTrial designNumber of childrenHigh dosesStimulant typePsychostimulantsAnxiety symptomsTreatmentChildrenRiskSymptomsAnxietyObsessive-compulsive symptom dimensions in a population-based, cross-sectional sample of school-aged children
Alvarenga PG, Cesar RC, Leckman JF, Moriyama TS, Torres AR, Bloch MH, Coughlin CG, Hoexter MQ, Manfro GG, Polanczyk GV, Miguel EC, do Rosario MC. Obsessive-compulsive symptom dimensions in a population-based, cross-sectional sample of school-aged children. Journal Of Psychiatric Research 2015, 62: 108-114. PMID: 25702286, DOI: 10.1016/j.jpsychires.2015.01.018.Peer-Reviewed Original ResearchConceptsSchool-aged childrenPsychiatric symptomsFamily History ScreenAdditional clinical factorsSymptom dimensionsCommunity-based sampleObsessive-compulsive symptom dimensionsClinical factorsObsessive-compulsive disorderPsychiatric comorbidityClinical impairmentSchool impairmentCross-sectional sampleAge 6Clinical samplesFamilial aggregationBiological mothersChildrenBiological relativesSymptomsPrevalenceAge distributionImpairmentNon-clinical samplePresent study
2013
Cognitive-Behavioral Therapy for Anxiety in Children With High-Functioning Autism: A Meta-analysis
Sukhodolsky DG, Bloch MH, Panza KE, Reichow B. Cognitive-Behavioral Therapy for Anxiety in Children With High-Functioning Autism: A Meta-analysis. Pediatrics 2013, 132: e1341-e1350. PMID: 24167175, PMCID: PMC3813396, DOI: 10.1542/peds.2013-1193.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyAutism spectrum disorderCo-occurring anxiety symptomsControl conditionSelf-reported anxietyAttention control conditionSample of childrenUsual control conditionFunctioning autismParent ratingsASD diagnosisBehavioral therapySpectrum disorderWaitlist controlAnxiety symptomsOverall effect sizeAnxietyClinician ratingsEffect sizeTreatment controlAdolescentsChildrenRatingsAutismTreatment changesSystematic Review and Meta-analysis of Pharmacological Treatment of the Symptoms of Attention-Deficit/Hyperactivity Disorder in Children with Pervasive Developmental Disorders
Reichow B, Volkmar FR, Bloch MH. Systematic Review and Meta-analysis of Pharmacological Treatment of the Symptoms of Attention-Deficit/Hyperactivity Disorder in Children with Pervasive Developmental Disorders. Journal Of Autism And Developmental Disorders 2013, 43: 2435-2441. PMID: 23468071, PMCID: PMC3787525, DOI: 10.1007/s10803-013-1793-z.Peer-Reviewed Original ResearchConceptsAttention-deficit/hyperactivity disorderADHD symptomsTrial of atomoxetineHyperactivity disorderPlacebo-controlled trialEfficacy of medicationsAdverse eventsPharmacological treatmentMethylphenidate trialMeta-AnalysisSystematic reviewSymptomsPervasive developmental disorderTrialsRelative efficacyIndividual trialsMedicationsDisordersChildrenDevelopmental disordersEfficacyPDDRandom effectsPlaceboClonidineN-Acetylcysteine in the Treatment of Pediatric Trichotillomania: A Randomized, Double-Blind, Placebo-Controlled Add-On Trial
Bloch MH, Panza KE, Grant JE, Pittenger C, Leckman JF. N-Acetylcysteine in the Treatment of Pediatric Trichotillomania: A Randomized, Double-Blind, Placebo-Controlled Add-On Trial. Journal Of The American Academy Of Child & Adolescent Psychiatry 2013, 52: 231-240. PMID: 23452680, PMCID: PMC3745012, DOI: 10.1016/j.jaac.2012.12.020.Peer-Reviewed Original ResearchConceptsN-acetylcysteinePharmacological interventionsPediatric trichotillomaniaBenefit of NACBehavioral therapySecondary outcome measuresTreatment of childrenClinician-rated improvementMassachusetts General HospitalTreat populationPlacebo groupPrimary outcomeNAC groupGeneral HospitalOutcome measuresTreatment respondersSecondary measuresPlaceboTreatment assignmentTrichotillomaniaLinear mixed modelsTrialsSignificant differencesChildrenTherapyAge and Gender Correlates of Pulling in Pediatric Trichotillomania
Panza KE, Pittenger C, Bloch MH. Age and Gender Correlates of Pulling in Pediatric Trichotillomania. Journal Of The American Academy Of Child & Adolescent Psychiatry 2013, 52: 241-249. PMID: 23452681, PMCID: PMC3745006, DOI: 10.1016/j.jaac.2012.12.019.Peer-Reviewed Original ResearchConceptsFrequent urgesCommon comorbid conditionsPediatric trichotillomaniaProspective longitudinal studyType of treatmentCross-sectional findingsClinical characteristicsComorbid conditionsStructured rating scaleTreatment trialsComorbid depressionRating ScaleAnxiety disordersOlder childrenTrichotillomaniaDecreased abilityLongitudinal studyMale participantsAgeChildrenGreater distressFemale participantsLower ratesSymptomsGender correlates
2010
Predictors of early adulthood quality of life in children with obsessive–compulsive disorder
Palermo SD, Bloch MH, Craiglow B, Landeros-Weisenberger A, Dombrowski PA, Panza K, Smith ME, Peterson BS, Leckman JF. Predictors of early adulthood quality of life in children with obsessive–compulsive disorder. Social Psychiatry And Psychiatric Epidemiology 2010, 46: 291-297. PMID: 20191262, PMCID: PMC3645906, DOI: 10.1007/s00127-010-0194-2.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderEarly adulthoodOCD symptomsImpaired Functioning ToolMethodsA longitudinal cohort studyLongitudinal cohort studyResultsForty-two percentSeverity of OCDAverage followClinical predictorsCohort studyPoor QoLResidual impairmentMild impairmentQoLSymptomsObjectivesThe goalAnxiety symptomsAdulthoodChildrenQoL.ChildhoodHoarding symptomsImpairmentDisorders
2009
Clinical course of Tourette syndrome
Bloch MH, Leckman JF. Clinical course of Tourette syndrome. Journal Of Psychosomatic Research 2009, 67: 497-501. PMID: 19913654, PMCID: PMC3974606, DOI: 10.1016/j.jpsychores.2009.09.002.Peer-Reviewed Original ResearchConceptsTourette syndromeComorbid conditionsObsessive-compulsive disorderClinical courseLong-term clinical courseChildhood-onset neuropsychiatric disorderEarly adulthoodLong-term outcomesAttention deficit disorderTic symptomsDepressive disorderTic disordersVocal ticsGeneral populationNeuropsychiatric disordersLiterature searchRelevant articlesDisordersSyndromeChildrenAdulthood outcomesOne-thirdSymptomsTraditional literature searchThree-quarters