2023
ASAM Clinical Considerations: Buprenorphine Treatment of Opioid Use Disorder for Individuals Using High-potency Synthetic Opioids
Weimer M, Herring A, Kawasaki S, Meyer M, Kleykamp B, Ramsey K. ASAM Clinical Considerations: Buprenorphine Treatment of Opioid Use Disorder for Individuals Using High-potency Synthetic Opioids. Journal Of Addiction Medicine 2023, 17: 632-639. PMID: 37934520, DOI: 10.1097/adm.0000000000001202.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnalgesics, OpioidBuprenorphineCentral Nervous System StimulantsHumansOpioid-Related DisordersProspective StudiesConceptsHigh potency synthetic opioidsOpioid use disorderBuprenorphine initiationBuprenorphine treatmentTreatment needsUse disordersClinical considerationsExpert consensusSynthetic opioidsTreatment of OUDProspective researchOpioid agonist treatmentLong-term treatmentDrug supplyPatients' treatment needsOpioid withdrawalBuprenorphine doseOUD treatmentAgonist treatmentDosing frequencyClinical questionsFrontline cliniciansClinical practiceTreatment settingsIndividualized strategiesBetter care at the bedside for hospitalized patients with opioid use disorder
Calcaterra S, Buresh M, Weimer M. Better care at the bedside for hospitalized patients with opioid use disorder. Journal Of Hospital Medicine 2023, 18: 1134-1138. PMID: 37016586, PMCID: PMC10548352, DOI: 10.1002/jhm.13099.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsLow-dose Initiation of Buprenorphine in Hospitalized Patients Using Buccal Buprenorphine: A Case Series
Adams K, Cohen S, Guerra M, Weimer M. Low-dose Initiation of Buprenorphine in Hospitalized Patients Using Buccal Buprenorphine: A Case Series. Journal Of Addiction Medicine 2023, 17: 474-476. PMID: 37579114, DOI: 10.1097/adm.0000000000001146.Peer-Reviewed Original ResearchMeSH KeywordsAftercareAnalgesics, OpioidBuprenorphineChronic PainHumansMethadoneNarcotic AntagonistsOpiate Substitution TreatmentOpioid-Related DisordersPatient DischargeConceptsOpioid use disorderBuprenorphine initiationSublingual buprenorphineChronic painBuccal buprenorphineCase seriesClinical Opiate Withdrawal Scale (COWS) scoresAddiction medicine serviceLow dose initiationSevere opioid withdrawalHistory of heroinOutpatient opioidsOpioid withdrawalAcute painFentanyl useHospitalized patientsMedian lengthPrescription refillsMedian numberModerate withdrawalInitiation strategiesBuprenorphineMedicine servicePatientsUse disordersPrecipitated Opioid Withdrawal Treated With Ketamine in a Hospitalized Patient: A Case Report
Christian N, Butner J, Evarts M, Weimer M. Precipitated Opioid Withdrawal Treated With Ketamine in a Hospitalized Patient: A Case Report. Journal Of Addiction Medicine 2023, 17: 488-490. PMID: 37579118, DOI: 10.1097/adm.0000000000001151.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAdultAnalgesics, OpioidBuprenorphineFentanylHumansKetamineMaleNaloxoneNarcotic AntagonistsOpiate Substitution TreatmentOpioid-Related DisordersSubstance Withdrawal SyndromeConceptsClinical Opiate Withdrawal Scale (COWS) scoresOpioid use disorderKetamine infusionOpioid withdrawalCase reportUse disordersScale scoreSevere opioid use disorderFull opioid agonistsHours of admissionEmergency department settingFirst case reportInpatient hospital settingLife-saving medicationsReceptor-mediated signalingLack of evidenceMale patientsFentanyl useOpioid agonistsEmergency departmentComplete resolutionDepartment settingClinical dilemmaAppropriate treatmentHospital setting
2022
Top Ten Tips Palliative Care Clinicians Should Know About Buprenorphine
Neale KJ, Weimer MB, Davis MP, Jones KF, Kullgren JG, Kale SS, Childers J, Broglio K, Merlin JS, Peck S, Francis SY, Bango J, Jones CA, Sager Z, Ho JJ. Top Ten Tips Palliative Care Clinicians Should Know About Buprenorphine. Journal Of Palliative Medicine 2022, 26: 120-130. PMID: 36067137, DOI: 10.1089/jpm.2022.0399.Commentaries, Editorials and LettersMeSH KeywordsAnalgesics, OpioidBuprenorphineHospice and Palliative Care NursingHumansOpioid-Related DisordersPalliative CareConceptsPalliative carePain managementPartial mu-opioid receptor agonistSerious illnessMu-opioid receptor agonistTop Ten TipsOpioid use disorderLife-limiting illnessPC cliniciansCare cliniciansOpioid misuseBuprenorphine useReceptor agonistNurse practitionersUse disordersPopulation-wide trendsIllnessBuprenorphineCliniciansPatientsAgonistsPharmacistsPhysiciansCareSocial workersManagement of opioid use disorder and associated conditions among hospitalized adults: A Consensus Statement from the Society of Hospital Medicine
Calcaterra SL, Martin M, Bottner R, Englander H, Weinstein Z, Weimer MB, Lambert E, Herzig SJ. Management of opioid use disorder and associated conditions among hospitalized adults: A Consensus Statement from the Society of Hospital Medicine. Journal Of Hospital Medicine 2022, 17: 744-756. PMID: 35880813, PMCID: PMC9474708, DOI: 10.1002/jhm.12893.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAdultAnalgesics, OpioidConsensusHospital MedicineHospitalizationHumansOpioid-Related DisordersConceptsOpioid use disorderConsensus statementHospitalized adultsOpioid withdrawalUse disordersTreatment of OUDDraft statementManagement of OUDHospital medicineAcute pain managementNumber of hospitalizationsHospital-based cliniciansFinal consensus statementOpioid-related overdoseHospital dischargeOpioid usePain managementWorking GroupCare transitionsInpatient settingObservational studyExpert consensusGuidance statementsPatientsSystematic reviewManagement of opioid use disorder, opioid withdrawal, and opioid overdose prevention in hospitalized adults: A systematic review of existing guidelines
Calcaterra SL, Bottner R, Martin M, Englander H, Weinstein ZM, Weimer MB, Lambert E, Ronan MV, Huerta S, Zaman T, Ullal M, Peterkin AF, Torres‐Lockhart K, Buresh M, O'Brien MT, Snyder H, Herzig SJ. Management of opioid use disorder, opioid withdrawal, and opioid overdose prevention in hospitalized adults: A systematic review of existing guidelines. Journal Of Hospital Medicine 2022, 17: 679-692. PMID: 35880821, PMCID: PMC9474657, DOI: 10.1002/jhm.12908.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAdultAnalgesics, OpioidBuprenorphineHospitalizationHumansMethadoneOpiate OverdoseOpioid-Related DisordersConceptsOpioid overdose preventionOpioid withdrawalOpioid useOUD treatmentOverdose preventionShort-acting opioid analgesicsOpioid use disorder managementAcute pain managementUse of methadoneOpioid use disorderEvaluation II (AGREE II) instrumentAppraisal of GuidelinesOpioid withdrawal managementUse of multimodalOpioid overdose reversalMethadone initiationNonopioid therapyHospitalized adultsBuprenorphine treatmentOpioid analgesicsPain managementTreatment guidelinesDiagnostic Statistical ManualOvid MEDLINEEdition criteriaThe X Waiver to Prescribe Buprenorphine: The Why and How
Jones K, Ho JJ, Merlin JS, Weimer M, Sager Z, Kapo J, Childers J. The X Waiver to Prescribe Buprenorphine: The Why and How. Journal Of Palliative Medicine 2022, 25: 1021-1023. PMID: 35775892, DOI: 10.1089/jpm.2022.0170.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsClinical Management of Opioid Withdrawal
Torres‐Lockhart K, Lu TY, Weimer MB, Stein MR, Cunningham CO. Clinical Management of Opioid Withdrawal. Addiction 2022, 117: 2540-2550. PMID: 35112746, DOI: 10.1111/add.15818.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnalgesics, OpioidBuprenorphineHumansOpiate Substitution TreatmentOpioid-Related DisordersSecondary PreventionSubstance Withdrawal SyndromeConceptsOpioid use disorderOpioid withdrawal managementOpioid withdrawalClinical managementWithdrawal managementLong-term treatmentAppropriate clinical managementPatient-centered approachRelapse prevention strategiesHarm reduction strategiesHigh-risk timeOUD treatmentAppropriate diagnosisOpioid overdoseUse disordersPrevention strategiesTreatment settingsNarrative reviewWithdrawalTreatmentComplex casesManagementRelapsePatientsOverdoseLow‐ and very low‐dose buprenorphine induction: new(ish) uses for an old(ish) medication?
Weimer MB, Fiellin DA. Low‐ and very low‐dose buprenorphine induction: new(ish) uses for an old(ish) medication? Addiction 2022, 117: 1507-1509. PMID: 35032081, DOI: 10.1111/add.15799.Commentaries, Editorials and LettersCardiac Surgeons’ Practices and Attitudes toward Addiction Care for Patients with Substance use Disorders
Tiako M, Mszar R, Brooks C, Bin Mahmood SU, Mori M, Vallabhajosyula P, Geirsson A, Weimer MB. Cardiac Surgeons’ Practices and Attitudes toward Addiction Care for Patients with Substance use Disorders. Substance Abuse 2022, 43: 206-211. PMID: 34038333, DOI: 10.1080/08897077.2021.1917475.Peer-Reviewed Original ResearchMeSH KeywordsAttitude of Health PersonnelCardiologyHumansOpioid-Related DisordersRetrospective StudiesSubstance Abuse, IntravenousSurgeonsConceptsSubstance use disordersUse disordersCardiac surgeonsSurgeon's practiceAddiction careInjection drug useOpioid use disorderMultivariable logistic regressionCare of patientsQuarter of surgeonsMost hospital settingsMinority of surgeonsMost patientsInfective endocarditisHospital settingAddiction specialistsPatientsMost surgeonsIDUsAddiction servicesLogistic regressionMOUDHealth systemSurgeonsLack of educationPerioperative Buprenorphine Management A Multidisciplinary Approach
Hickey T, Abelleira A, Acampora G, Becker WC, Falker CG, Nazario M, Weimer MB. Perioperative Buprenorphine Management A Multidisciplinary Approach. Medical Clinics Of North America 2022, 106: 169-185. PMID: 34823729, DOI: 10.1016/j.mcna.2021.09.001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAcetaminophenAgedAnalgesics, Non-NarcoticAnalgesics, OpioidAnti-Inflammatory Agents, Non-SteroidalArthroplasty, Replacement, HipBuprenorphineCombined Modality TherapyDrug CompoundingFemaleHumansInterdisciplinary CommunicationMaleOpiate Substitution TreatmentOpioid-Related DisordersPainPain ManagementPain, PostoperativePerioperative CareReceptors, Opioid, muConceptsOpioid use disorderBuprenorphine treatmentMu-opioid receptor availabilityAgonist opioid treatmentMultimodal analgesic strategyAnti-inflammatory drugsLong-term buprenorphine treatmentAnalgesic strategiesNonopioid adjunctsOpioid treatmentPerioperative strategiesHospital dischargePerioperative managementBuprenorphine formulationsSimultaneous administrationRegional anesthesiaEffective treatmentUse disordersReceptor availabilityMultidisciplinary approachBuprenorphinePatientsTreatmentPainAnesthesiaInfectious Complications of Injection Drug Use
Marks LR, Nolan NS, Liang SY, Durkin MJ, Weimer MB. Infectious Complications of Injection Drug Use. Medical Clinics Of North America 2022, 106: 187-200. PMID: 34823730, DOI: 10.1016/j.mcna.2021.08.006.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsInjection drug useInjection drug use-related infective endocarditisHuman immunodeficiency virusHepatitis C virusInfectious complicationsDrug useCommon infectious complicationOpioid use disorderCommon risk factorsCause of deathOpioid overdose epidemicViral hepatitisInfective endocarditisImmunodeficiency virusClinical syndromeHIV outbreakInfectious disease epidemicsC virusRisk factorsIntravenous administrationOverdose epidemicUse disordersModel of treatmentMedical careInfectious diseases
2021
Low Dose Initiation of Buprenorphine: A Narrative Review and Practical Approach
Cohen SM, Weimer MB, Levander XA, Peckham AM, Tetrault JM, Morford KL. Low Dose Initiation of Buprenorphine: A Narrative Review and Practical Approach. Journal Of Addiction Medicine 2021, 16: 399-406. PMID: 34954746, DOI: 10.1097/adm.0000000000000945.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidBuprenorphineHumansNarcoticsOpiate Substitution TreatmentOpioid-Related DisordersSubstance Withdrawal SyndromeConceptsLow dose initiationFull opioid agonistsDose initiationOpioid withdrawal symptomsOpioid agonistsBuprenorphine doseWithdrawal symptomsHigh potency synthetic opioidsOpioid use disorderAppropriate clinical situationsMu-opioid receptorsBuprenorphine initiationOpioid withdrawalStarting doseOutpatient settingCare coordinationDose changesOverdose deathsCurrent evidenceUse disordersBuprenorphineTherapeutic levelsClinical situationsSynthetic opioidsNarrative reviewX-Waiver Exemption in the Treatment of Opioid Use Disorder—Reply
Weimer MB, Wakeman SE, Saitz R. X-Waiver Exemption in the Treatment of Opioid Use Disorder—Reply. JAMA 2021, 326: 442-443. PMID: 34342621, DOI: 10.1001/jama.2021.8270.Commentaries, Editorials and LettersRemoving One Barrier to Opioid Use Disorder Treatment
Weimer MB, Wakeman SE, Saitz R. Removing One Barrier to Opioid Use Disorder Treatment. JAMA 2021, 325: 1147-1148. PMID: 33630020, DOI: 10.1001/jama.2021.0958.Commentaries, Editorials and LettersMeSH KeywordsAnalgesics, OpioidBuprenorphineHumansLegislation, DrugOpiate Substitution TreatmentOpioid EpidemicOpioid-Related DisordersPractice Guidelines as TopicUnited StatesAdapting inpatient addiction medicine consult services during the COVID-19 pandemic
Harris MTH, Peterkin A, Bach P, Englander H, Lapidus E, Rolley T, Weimer MB, Weinstein ZM. Adapting inpatient addiction medicine consult services during the COVID-19 pandemic. Addiction Science & Clinical Practice 2021, 16: 13. PMID: 33627183, PMCID: PMC7903401, DOI: 10.1186/s13722-021-00221-1.Commentaries, Editorials and LettersMeSH KeywordsBritish ColumbiaBuprenorphineConnecticutCOVID-19Cross-Cultural ComparisonDelivery of Health CareForecastingHealth Plan ImplementationHealth Services AccessibilityHumansMassachusettsOpioid-Related DisordersOregonPatient AdmissionPatient Care TeamPatient DischargeRemote ConsultationSubstance-Related DisordersTelemedicineConceptsUse disordersCOVID-19 isolation unitsYale-New Haven HospitalHigh-risk patientsNovel coronavirus disease 2019 (COVID-19) pandemicSt. Paul's HospitalAddiction medicine consult serviceOpioid use disorderBoston Medical CenterCoronavirus disease 2019 (COVID-19) pandemicNew Haven HospitalTelephone-based consultationsAlcohol use disorderDisease 2019 pandemicHealth care systemPublic health crisisHospitalized patientsPaul's HospitalOutpatient settingCare coordinationPatient visitsVulnerable patientsConsult serviceBenzodiazepine taperMedical Center
2020
Hospital-based Buprenorphine Micro-dose Initiation
Weimer MB, Guerra M, Morrow G, Adams K. Hospital-based Buprenorphine Micro-dose Initiation. Journal Of Addiction Medicine 2020, 15: 255-257. PMID: 32960820, DOI: 10.1097/adm.0000000000000745.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAnalgesics, OpioidBuprenorphineHospitalsHumansOpioid-Related DisordersSubstance Withdrawal SyndromePatients With Opioid Use Disorder Deserve Trained Providers.
Weimer MB, Tetrault JM, Fiellin DA. Patients With Opioid Use Disorder Deserve Trained Providers. Annals Of Internal Medicine 2020, 172: 774-775. PMID: 32479150, DOI: 10.7326/l20-0084.Commentaries, Editorials and Letters
2019
Patients With Opioid Use Disorder Deserve Trained Providers.
Weimer MB, Tetrault JM, Fiellin DA. Patients With Opioid Use Disorder Deserve Trained Providers. Annals Of Internal Medicine 2019, 171: 931-932. PMID: 31766053, DOI: 10.7326/m19-2303.Commentaries, Editorials and Letters