2023
ASAM Clinical Considerations: Buprenorphine Treatment of Opioid Use Disorder for Individuals Using High-potency Synthetic Opioids
Weimer M, Herring A, Kawasaki S, Meyer M, Kleykamp B, Ramsey K. ASAM Clinical Considerations: Buprenorphine Treatment of Opioid Use Disorder for Individuals Using High-potency Synthetic Opioids. Journal Of Addiction Medicine 2023, 17: 632-639. PMID: 37934520, DOI: 10.1097/adm.0000000000001202.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnalgesics, OpioidBuprenorphineCentral Nervous System StimulantsHumansOpioid-Related DisordersProspective StudiesConceptsHigh potency synthetic opioidsOpioid use disorderBuprenorphine initiationBuprenorphine treatmentTreatment needsUse disordersClinical considerationsExpert consensusSynthetic opioidsTreatment of OUDProspective researchOpioid agonist treatmentLong-term treatmentDrug supplyPatients' treatment needsOpioid withdrawalBuprenorphine doseOUD treatmentAgonist treatmentDosing frequencyClinical questionsFrontline cliniciansClinical practiceTreatment settingsIndividualized strategiesBetter care at the bedside for hospitalized patients with opioid use disorder
Calcaterra S, Buresh M, Weimer M. Better care at the bedside for hospitalized patients with opioid use disorder. Journal Of Hospital Medicine 2023, 18: 1134-1138. PMID: 37016586, PMCID: PMC10548352, DOI: 10.1002/jhm.13099.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsLow-dose Initiation of Buprenorphine in Hospitalized Patients Using Buccal Buprenorphine: A Case Series
Adams K, Cohen S, Guerra M, Weimer M. Low-dose Initiation of Buprenorphine in Hospitalized Patients Using Buccal Buprenorphine: A Case Series. Journal Of Addiction Medicine 2023, 17: 474-476. PMID: 37579114, DOI: 10.1097/adm.0000000000001146.Peer-Reviewed Original ResearchConceptsOpioid use disorderBuprenorphine initiationSublingual buprenorphineChronic painBuccal buprenorphineCase seriesClinical Opiate Withdrawal Scale (COWS) scoresAddiction medicine serviceLow dose initiationSevere opioid withdrawalHistory of heroinOutpatient opioidsOpioid withdrawalAcute painFentanyl useHospitalized patientsMedian lengthPrescription refillsMedian numberModerate withdrawalInitiation strategiesBuprenorphineMedicine servicePatientsUse disordersPrecipitated Opioid Withdrawal Treated With Ketamine in a Hospitalized Patient: A Case Report
Christian N, Butner J, Evarts M, Weimer M. Precipitated Opioid Withdrawal Treated With Ketamine in a Hospitalized Patient: A Case Report. Journal Of Addiction Medicine 2023, 17: 488-490. PMID: 37579118, DOI: 10.1097/adm.0000000000001151.Peer-Reviewed Case Reports and Technical NotesConceptsClinical Opiate Withdrawal Scale (COWS) scoresOpioid use disorderKetamine infusionOpioid withdrawalCase reportUse disordersScale scoreSevere opioid use disorderFull opioid agonistsHours of admissionEmergency department settingFirst case reportInpatient hospital settingLife-saving medicationsReceptor-mediated signalingLack of evidenceMale patientsFentanyl useOpioid agonistsEmergency departmentComplete resolutionDepartment settingClinical dilemmaAppropriate treatmentHospital setting
2022
Top Ten Tips Palliative Care Clinicians Should Know About Buprenorphine
Neale KJ, Weimer MB, Davis MP, Jones KF, Kullgren JG, Kale SS, Childers J, Broglio K, Merlin JS, Peck S, Francis SY, Bango J, Jones CA, Sager Z, Ho JJ. Top Ten Tips Palliative Care Clinicians Should Know About Buprenorphine. Journal Of Palliative Medicine 2022, 26: 120-130. PMID: 36067137, DOI: 10.1089/jpm.2022.0399.Commentaries, Editorials and LettersMeSH KeywordsAnalgesics, OpioidBuprenorphineHospice and Palliative Care NursingHumansOpioid-Related DisordersPalliative CareConceptsPalliative carePain managementPartial mu-opioid receptor agonistSerious illnessMu-opioid receptor agonistTop Ten TipsOpioid use disorderLife-limiting illnessPC cliniciansCare cliniciansOpioid misuseBuprenorphine useReceptor agonistNurse practitionersUse disordersPopulation-wide trendsIllnessBuprenorphineCliniciansPatientsAgonistsPharmacistsPhysiciansCareSocial workersManagement of opioid use disorder and associated conditions among hospitalized adults: A Consensus Statement from the Society of Hospital Medicine
Calcaterra SL, Martin M, Bottner R, Englander H, Weinstein Z, Weimer MB, Lambert E, Herzig SJ. Management of opioid use disorder and associated conditions among hospitalized adults: A Consensus Statement from the Society of Hospital Medicine. Journal Of Hospital Medicine 2022, 17: 744-756. PMID: 35880813, PMCID: PMC9474708, DOI: 10.1002/jhm.12893.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAdultAnalgesics, OpioidConsensusHospital MedicineHospitalizationHumansOpioid-Related DisordersConceptsOpioid use disorderConsensus statementHospitalized adultsOpioid withdrawalUse disordersTreatment of OUDDraft statementManagement of OUDHospital medicineAcute pain managementNumber of hospitalizationsHospital-based cliniciansFinal consensus statementOpioid-related overdoseHospital dischargeOpioid usePain managementWorking GroupCare transitionsInpatient settingObservational studyExpert consensusGuidance statementsPatientsSystematic reviewManagement of opioid use disorder, opioid withdrawal, and opioid overdose prevention in hospitalized adults: A systematic review of existing guidelines
Calcaterra SL, Bottner R, Martin M, Englander H, Weinstein ZM, Weimer MB, Lambert E, Ronan MV, Huerta S, Zaman T, Ullal M, Peterkin AF, Torres‐Lockhart K, Buresh M, O'Brien MT, Snyder H, Herzig SJ. Management of opioid use disorder, opioid withdrawal, and opioid overdose prevention in hospitalized adults: A systematic review of existing guidelines. Journal Of Hospital Medicine 2022, 17: 679-692. PMID: 35880821, PMCID: PMC9474657, DOI: 10.1002/jhm.12908.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAdultAnalgesics, OpioidBuprenorphineHospitalizationHumansMethadoneOpiate OverdoseOpioid-Related DisordersConceptsOpioid overdose preventionOpioid withdrawalOpioid useOUD treatmentOverdose preventionShort-acting opioid analgesicsOpioid use disorder managementAcute pain managementUse of methadoneOpioid use disorderEvaluation II (AGREE II) instrumentAppraisal of GuidelinesOpioid withdrawal managementUse of multimodalOpioid overdose reversalMethadone initiationNonopioid therapyHospitalized adultsBuprenorphine treatmentOpioid analgesicsPain managementTreatment guidelinesDiagnostic Statistical ManualOvid MEDLINEEdition criteriaClinical Management of Opioid Withdrawal
Torres‐Lockhart K, Lu TY, Weimer MB, Stein MR, Cunningham CO. Clinical Management of Opioid Withdrawal. Addiction 2022, 117: 2540-2550. PMID: 35112746, DOI: 10.1111/add.15818.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnalgesics, OpioidBuprenorphineHumansOpiate Substitution TreatmentOpioid-Related DisordersSecondary PreventionSubstance Withdrawal SyndromeConceptsOpioid use disorderOpioid withdrawal managementOpioid withdrawalClinical managementWithdrawal managementLong-term treatmentAppropriate clinical managementPatient-centered approachRelapse prevention strategiesHarm reduction strategiesHigh-risk timeOUD treatmentAppropriate diagnosisOpioid overdoseUse disordersPrevention strategiesTreatment settingsNarrative reviewWithdrawalTreatmentComplex casesManagementRelapsePatientsOverdoseLow‐ and very low‐dose buprenorphine induction: new(ish) uses for an old(ish) medication?
Weimer MB, Fiellin DA. Low‐ and very low‐dose buprenorphine induction: new(ish) uses for an old(ish) medication? Addiction 2022, 117: 1507-1509. PMID: 35032081, DOI: 10.1111/add.15799.Commentaries, Editorials and LettersPerioperative Buprenorphine Management A Multidisciplinary Approach
Hickey T, Abelleira A, Acampora G, Becker WC, Falker CG, Nazario M, Weimer MB. Perioperative Buprenorphine Management A Multidisciplinary Approach. Medical Clinics Of North America 2022, 106: 169-185. PMID: 34823729, DOI: 10.1016/j.mcna.2021.09.001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAcetaminophenAgedAnalgesics, Non-NarcoticAnalgesics, OpioidAnti-Inflammatory Agents, Non-SteroidalArthroplasty, Replacement, HipBuprenorphineCombined Modality TherapyDrug CompoundingFemaleHumansInterdisciplinary CommunicationMaleOpiate Substitution TreatmentOpioid-Related DisordersPainPain ManagementPain, PostoperativePerioperative CareReceptors, Opioid, muConceptsOpioid use disorderBuprenorphine treatmentMu-opioid receptor availabilityAgonist opioid treatmentMultimodal analgesic strategyAnti-inflammatory drugsLong-term buprenorphine treatmentAnalgesic strategiesNonopioid adjunctsOpioid treatmentPerioperative strategiesHospital dischargePerioperative managementBuprenorphine formulationsSimultaneous administrationRegional anesthesiaEffective treatmentUse disordersReceptor availabilityMultidisciplinary approachBuprenorphinePatientsTreatmentPainAnesthesia
2021
Low Dose Initiation of Buprenorphine: A Narrative Review and Practical Approach
Cohen SM, Weimer MB, Levander XA, Peckham AM, Tetrault JM, Morford KL. Low Dose Initiation of Buprenorphine: A Narrative Review and Practical Approach. Journal Of Addiction Medicine 2021, 16: 399-406. PMID: 34954746, DOI: 10.1097/adm.0000000000000945.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidBuprenorphineHumansNarcoticsOpiate Substitution TreatmentOpioid-Related DisordersSubstance Withdrawal SyndromeConceptsLow dose initiationFull opioid agonistsDose initiationOpioid withdrawal symptomsOpioid agonistsBuprenorphine doseWithdrawal symptomsHigh potency synthetic opioidsOpioid use disorderAppropriate clinical situationsMu-opioid receptorsBuprenorphine initiationOpioid withdrawalStarting doseOutpatient settingCare coordinationDose changesOverdose deathsCurrent evidenceUse disordersBuprenorphineTherapeutic levelsClinical situationsSynthetic opioidsNarrative reviewRemoving One Barrier to Opioid Use Disorder Treatment
Weimer MB, Wakeman SE, Saitz R. Removing One Barrier to Opioid Use Disorder Treatment. JAMA 2021, 325: 1147-1148. PMID: 33630020, DOI: 10.1001/jama.2021.0958.Commentaries, Editorials and Letters
2020
Hospital-based Buprenorphine Micro-dose Initiation
Weimer MB, Guerra M, Morrow G, Adams K. Hospital-based Buprenorphine Micro-dose Initiation. Journal Of Addiction Medicine 2020, 15: 255-257. PMID: 32960820, DOI: 10.1097/adm.0000000000000745.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAnalgesics, OpioidBuprenorphineHospitalsHumansOpioid-Related DisordersSubstance Withdrawal Syndrome
2019
Patients With Opioid Use Disorder Deserve Trained Providers.
Weimer MB, Tetrault JM, Fiellin DA. Patients With Opioid Use Disorder Deserve Trained Providers. Annals Of Internal Medicine 2019, 171: 931-932. PMID: 31766053, DOI: 10.7326/m19-2303.Commentaries, Editorials and Letters
2017
Systemic Pharmacologic Therapies for Low Back Pain: A Systematic Review for an American College of Physicians Clinical Practice Guideline.
Chou R, Deyo R, Friedly J, Skelly A, Weimer M, Fu R, Dana T, Kraegel P, Griffin J, Grusing S. Systemic Pharmacologic Therapies for Low Back Pain: A Systematic Review for an American College of Physicians Clinical Practice Guideline. Annals Of Internal Medicine 2017, 166: 480-492. PMID: 28192790, DOI: 10.7326/m16-2458.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsChronic low back painAcute low back painLow back painSystemic pharmacologic therapyBack painPain reliefPharmacologic therapySystemic medicationsAmerican CollegeSystematic reviewPhysicians Clinical Practice GuidelineRadicular low back painShort-term pain reliefNonsteroidal anti-inflammatory drugsSecond verified accuracyCochrane Central RegisterClinical practice guidelinesAnti-inflammatory drugsSkeletal muscle relaxantsShort-term trialsEnglish-language studiesModest effectSystemic corticosteroidsAntiseizure medicationsCentral Register
2016
A Chronic Opioid Therapy Dose Reduction Policy in Primary Care
Weimer MB, Hartung DM, Ahmed S, Nicolaidis C. A Chronic Opioid Therapy Dose Reduction Policy in Primary Care. Substance Abuse 2016, 37: 141-147. PMID: 26685018, DOI: 10.1080/08897077.2015.1129526.Peer-Reviewed Original ResearchConceptsHigh-dose opioidsChronic opioid therapyOpioid therapyOpioid doseDose taperAcademic primary care clinicHigh-dose opioid therapyHigher opioid doseIntervention of educationOpioid dose reductionTotal opioid doseRetrospective cohort studyCharacteristics of patientsPrimary care clinicsOpioid use disorderMedication-assisted treatmentAverage daily doseOnly significant associationMorphine equivalentsOpioid dosesCohort studyPatient characteristicsDaily doseCare clinicsChronic painCorrelates of prescription opioid therapy in Veterans with chronic pain and history of substance use disorder
Lovejoy TI, Dobscha SK, Turk DC, Weimer MB, Morasco BJ. Correlates of prescription opioid therapy in Veterans with chronic pain and history of substance use disorder. The Journal Of Rehabilitation Research And Development 2016, 53: 25-36. PMID: 27005461, DOI: 10.1682/jrrd.2014.10.0230.Peer-Reviewed Original ResearchConceptsLong-term opioid therapyPrescription opioid therapySubstance use disordersOpioid therapyChronic painSUD historyPain diagnosisUse disordersChronic noncancer painVeterans Affairs electronic medical recordsPain-related functioningLow chronic painElectronic medical recordsNoncancer painOpioid medicationsOpioid prescriptionsClinical characteristicsPain severityPain interferencePharmacy dataMedical recordsPainPsychosocial questionnairesPatientsTherapy
2014
Research Gaps on Methadone Harms and Comparative Harms: Findings From a Review of the Evidence for an American Pain Society and College on Problems of Drug Dependence Clinical Practice Guideline
Weimer MB, Chou R. Research Gaps on Methadone Harms and Comparative Harms: Findings From a Review of the Evidence for an American Pain Society and College on Problems of Drug Dependence Clinical Practice Guideline. Journal Of Pain 2014, 15: 366-376. PMID: 24685460, DOI: 10.1016/j.jpain.2014.01.496.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAmerican Pain SocietyClinical practice guidelinesMethadone safetyPain SocietyAdverse eventsPractice guidelinesInsufficient evidenceEvidence-based clinical practice guidelinesSystematic reviewDependence Clinical Practice GuidelineMost guideline recommendationsTitration of therapyProlonged QTc intervalUrine drug testingLack of evidenceMethadone useGuideline recommendationsQTc intervalCochrane LibrarySafe prescribingRisk factorsUpdate searchOvid MEDLINEInclusion criteriaMethadone prescribing
2013
Patterns of care and side effects for patients prescribed methadone for treatment of chronic pain.
Macey TA, Weimer MB, Grimaldi EM, Dobscha SK, Morasco BJ. Patterns of care and side effects for patients prescribed methadone for treatment of chronic pain. Journal Of Opioid Management 2013, 9: 325-33. PMID: 24353045, PMCID: PMC4001870, DOI: 10.5055/jom.2013.0175.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAnalgesics, OpioidChronic PainElectrocardiographyFemaleHumansMaleMethadoneMiddle AgedRetrospective StudiesConceptsChronic painSide effectsSingle VA medical centerInitiation of methadoneInsufficient pain reliefCardiac side effectsChronic pain patientsHealth service utilizationPatterns of careMedical record dataVA Medical CenterNew initiationOpioid initiationPain reliefPain patientsQTc prolongationSustained releaseService utilizationClinical dataClinical significanceMedical CenterCalendar year 2008PatientsClinical information systemsMethadone