2023
Homeostatic, Non-Canonical Role of Macrophage Elastase in Vascular Integrity
Salarian M, Ghim M, Toczek J, Han J, Weiss D, Spronck B, Ramachandra A, Jung J, Kukreja G, Zhang J, Lakheram D, Kim S, Humphrey J, Sadeghi M. Homeostatic, Non-Canonical Role of Macrophage Elastase in Vascular Integrity. Circulation Research 2023, 132: 432-448. PMID: 36691905, PMCID: PMC9930896, DOI: 10.1161/circresaha.122.322096.Peer-Reviewed Original ResearchConceptsMMP-12 deficiencyAdverse aortic remodelingAbdominal aortic aneurysmAng IIAortic remodelingAortic aneurysmMMP-12Complement component 3 levelsNeutrophil extracellular traps markersAbdominal aortic aneurysm ruptureAortic aneurysm ruptureElastic lamina degradationPlasma complement componentsAortic ruptureC3 levelsComplement depositionPlasma C5aMore neutrophilsVascular remodelingAneurysm ruptureNeutrophil elastaseAortic integrityMatrix metalloproteinaseComplement inhibitorsNETosis pathway
2021
Characteristics and outcomes of small abdominal aortic aneurysm rupture in the American College of Surgeons National Surgical Quality Improvement Program database
Bellamkonda K, Nassiri N, Sadeghi MM, Zhang Y, Guzman RJ, Ochoa Chaar CI. Characteristics and outcomes of small abdominal aortic aneurysm rupture in the American College of Surgeons National Surgical Quality Improvement Program database. Journal Of Vascular Surgery 2021, 74: 729-737. PMID: 33617982, DOI: 10.1016/j.jvs.2021.01.063.Peer-Reviewed Original ResearchConceptsEndovascular aneurysm repairRAAA groupElective repairSmall AAAsRAAA repairAAA repairAneurysm repairAmerican CollegeSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseSurgeons National Surgical Quality Improvement ProgramElective abdominal aortic aneurysm repairNational Surgical Quality Improvement ProgramShorter mean operative timeQuality Improvement Program databaseAbdominal aortic aneurysm repairLower body mass indexSurgical Quality Improvement ProgramImprovement Program databaseMean operative timeAortic aneurysm repairOpen AAA repairBody mass indexMultivariable logistic regressionAbdominal aortic aneurysm rupture