Low doses ionizing radiation enhances the invasiveness of breast cancer cells by inducing epithelial–mesenchymal transition
Zhang X, Li X, Zhang N, Yang Q, Moran MS. Low doses ionizing radiation enhances the invasiveness of breast cancer cells by inducing epithelial–mesenchymal transition. Biochemical And Biophysical Research Communications 2011, 412: 188-192. PMID: 21810413, DOI: 10.1016/j.bbrc.2011.07.074.Peer-Reviewed Original ResearchMeSH KeywordsActinsBreast NeoplasmsCadherinsCell Line, TumorDose-Response Relationship, RadiationDown-RegulationEpithelial-Mesenchymal TransitionFemaleGamma RaysHumansNeoplasm InvasivenessUp-RegulationVimentinConceptsEpithelial-mesenchymal transitionBreast cancer cellsMCF-7 cellsCancer cellsMCF-7 breast cancer cellsEpithelial differentiation markersBreast cancerEMT markersLow doseMesenchymal markersTherapeutic effectivenessTranswell assaysMolecular alterationsLow dosesMesenchymal transitionRT-PCRCell invasionEnhanced migrationDifferentiation markersLDIRInvasivenessMarkersCellsPhenotypic changesInvasion