2021
Targeting the CSF1/CSF1R axis is a potential treatment strategy for malignant meningiomas
Yeung J, Yaghoobi V, Miyagishima D, Vesely MD, Zhang T, Badri T, Nassar A, Han X, Sanmamed MF, Youngblood M, Peyre M, Kalamarides M, Rimm DL, Gunel M, Chen L. Targeting the CSF1/CSF1R axis is a potential treatment strategy for malignant meningiomas. Neuro-Oncology 2021, 23: 1922-1935. PMID: 33914067, PMCID: PMC8563319, DOI: 10.1093/neuonc/noab075.Peer-Reviewed Original ResearchConceptsColony-stimulating factor-1Myeloid cellsMalignant meningiomasTumor microenvironmentCSF1/CSF1RRNA-seqRNA sequencingHuman meningiomasImmune subsetsGene expressionT cellsTreatment strategiesNormalization cancer immunotherapyImportant regulatorCell typesNovel immunocompetent murine modelDeath ligand 1 (PD-L1) expressionCell death receptor-1Immunosuppressive myeloid cellsDeath receptor-1Ligand 1 expressionFactor 1Immune cell typesImmunocompetent murine modelEffective treatment strategies
2001
Evidence for an Atrial Natriuretic Peptide–-Like Gene in Plants
Vesely M, Gower W, Perez-Lamboy G, Overton R, Graddy L, Vesely D. Evidence for an Atrial Natriuretic Peptide–-Like Gene in Plants. Experimental Biology And Medicine 2001, 226: 61-65. PMID: 11368240, DOI: 10.1177/153537020122600109.Peer-Reviewed Original ResearchConceptsGene sequencesTotal plant RNAAtrial natriuretic-like peptidesNorthern blot analysisPlant RNAAnimal kingdomGene expressionGenomic DNAPeptide genesSouthern blotNorthern blotGenesPlantsEnglish ivyBlot analysisLeavesTotal RNAHormonal systemsRNANatriuretic peptide geneSequenceExpressionBlotRootsAtrial natriuretic peptide gene
1999
Environmental Upregulation of the Atrial Natriuretic Peptide Gene in the Living Fossil,Limulus polyphemus
Vesely M, Vesely D. Environmental Upregulation of the Atrial Natriuretic Peptide Gene in the Living Fossil,Limulus polyphemus. Biochemical And Biophysical Research Communications 1999, 254: 751-756. PMID: 9920813, DOI: 10.1006/bbrc.1998.9990.Peer-Reviewed Original ResearchConceptsGene expressionLimulus polyphemusNorthern blot analysisLow salinityVertebrate heartLiving fossilPeptide genesMessenger RNAHorseshoe crabsPeptide gene expressionBlot analysisANP gene expressionFreshwaterMedium salinityGillsExpressionSalinityAtrial natriuretic peptide gene expressionNatriuretic peptide genePolyphemusAtrial natriuretic peptide geneGenesRNACrabsFossils