2003
Differential αv integrin–mediated Ras-ERK signaling during two pathways of angiogenesis
Hood JD, Frausto R, Kiosses WB, Schwartz MA, Cheresh DA. Differential αv integrin–mediated Ras-ERK signaling during two pathways of angiogenesis. Journal Of Cell Biology 2003, 162: 933-943. PMID: 12952943, PMCID: PMC2172815, DOI: 10.1083/jcb.200304105.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChick EmbryoEnzyme ActivationFibroblast Growth Factor 2Focal Adhesion Protein-Tyrosine KinasesIntegrin alphaVbeta3IntegrinsMitogen-Activated Protein KinasesNeovascularization, PhysiologicP21-Activated KinasesProtein Serine-Threonine KinasesProtein-Tyrosine KinasesProto-Oncogene Proteins c-rafRas ProteinsReceptors, VitronectinSignal TransductionSrc-Family KinasesVascular Endothelial Growth Factor AConceptsPathways of angiogenesisC-RafDistinct vascular responsesDownstream of RasUpstream of RasC-Raf activationC-Raf activityKinase-dependent phosphorylationRas-ERK pathwayInhibition of FAKVascular responsesPhosphorylation/activationSignal-related kinaseEndothelial cell survivalSerine 338Blood vesselsRas-ERKActive RAChick chorioallantoic membraneRA activityAngiogenesisERK activityRetroviral deliveryVEGFCell survival
2001
Activation of integrins in endothelial cells by fluid shear stress mediates Rho‐dependent cytoskeletal alignment
Tzima E, del Pozo M, Shattil S, Chien S, Schwartz M. Activation of integrins in endothelial cells by fluid shear stress mediates Rho‐dependent cytoskeletal alignment. The EMBO Journal 2001, 20: 4639-4647. PMID: 11532928, PMCID: PMC125600, DOI: 10.1093/emboj/20.17.4639.Peer-Reviewed Original ResearchAnimalsAortaCattleCells, CulturedCulture Media, Serum-FreeCytoskeletonEndothelium, VascularExtracellular Matrix ProteinsFibronectinsGreen Fluorescent ProteinsIntegrinsKineticsLuminescent ProteinsProtein ConformationReceptors, VitronectinRecombinant ProteinsRho GTP-Binding ProteinsStress, MechanicalTime FactorsTransfectionRac recruits high-affinity integrin αvβ3 to lamellipodia in endothelial cell migration
Kiosses W, Shattil S, Pampori N, Schwartz M. Rac recruits high-affinity integrin αvβ3 to lamellipodia in endothelial cell migration. Nature Cell Biology 2001, 3: 316-320. PMID: 11231584, DOI: 10.1038/35060120.Peer-Reviewed Original ResearchAndrostadienesAnimalsAntibodies, MonoclonalCattleCell MovementCells, CulturedChromonesCollagenEndothelium, VascularEnzyme InhibitorsGenes, ReporterImmunoglobulin FragmentsMicroinjectionsMicroscopy, FluorescenceMorpholinesPhosphoinositide-3 Kinase InhibitorsProtein BindingPseudopodiaRac GTP-Binding ProteinsReceptors, VitronectinRecombinant Fusion ProteinsTransfectionWortmanninIntegrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands
Jalali S, del Pozo M, Chen K, Miao H, Li Y, Schwartz M, Shyy J, Chien S. Integrin-mediated mechanotransduction requires its dynamic interaction with specific extracellular matrix (ECM) ligands. Proceedings Of The National Academy Of Sciences Of The United States Of America 2001, 98: 1042-1046. PMID: 11158591, PMCID: PMC14705, DOI: 10.1073/pnas.98.3.1042.Peer-Reviewed Original ResearchAdaptor Proteins, Signal TransducingAdaptor Proteins, Vesicular TransportAntigens, CDCells, CulturedCollagenEndothelium, VascularExtracellular MatrixExtracellular Matrix ProteinsFibrinogenFibronectinsHumansIntegrin beta1Integrin beta3IntegrinsJNK Mitogen-Activated Protein KinasesLamininLigandsMitogen-Activated Protein KinasesPlatelet Membrane GlycoproteinsProteinsReceptors, VitronectinShc Signaling Adaptor ProteinsSignal TransductionSrc Homology 2 Domain-Containing, Transforming Protein 1Stress, MechanicalUmbilical VeinsVitronectin
1997
Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo.
Brooks P, Klemke R, Schon S, Lewis J, Schwartz M, Cheresh D. Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo. Journal Of Clinical Investigation 1997, 99: 1390-1398. PMID: 9077549, PMCID: PMC507955, DOI: 10.1172/jci119298.Peer-Reviewed Original ResearchConceptsAlpha v beta 5Integrin alpha v beta 5Beta 5Growth factor-mediated signalsInsulin-like growth factor receptorSpontaneous pulmonary metastasesTumor cell metastasisMultiple tumor cell typesGrowth factor receptorIntegrin ligationCell motilityAdhesion proteinsTumor cell interactionsFunctional cooperationTumor cell growthCytokine receptorsTumor cell typesPulmonary metastasesCell typesCell metastasisCell growthMultiple tumor typesMetastatic cascadeTumor cellsFactor receptor
1996
Protein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation.
Lewis J, Cheresh D, Schwartz M. Protein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation. Journal Of Cell Biology 1996, 134: 1323-1332. PMID: 8794871, PMCID: PMC2120976, DOI: 10.1083/jcb.134.5.1323.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell AdhesionCell Adhesion MoleculesCricetinaeCytoskeletal ProteinsCytoskeletonEnzyme ActivationFocal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine KinasesHumansIntegrinsMicroscopy, ConfocalPhosphorylationProtein Kinase CProtein-Tyrosine KinasesReceptors, VitronectinTumor Cells, CulturedVitronectinConceptsFocal adhesion kinaseAlpha v beta 5Protein kinase CAlpha v beta 3Phosphorylation of FAKActivation of PKCIntegrin alpha v beta 3Beta 3Kinase CBeta 5Focal adhesion proteinsFocal adhesion kinase phosphorylationAlpha vPKC inhibitor calphostin CTreatment of cellsCytoskeletal associationAdhesion kinaseTyrosine phosphorylationAdhesion proteinsCytoskeletal proteinsIntracellular proteinsCell spreadingKinase phosphorylationTalinTensin