Mark Estacion, PhD
Research ScientistDownloadHi-Res Photo
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Additional Titles
Deputy Director, Center for Neuroscience & Regeneration Research, Neurology
About
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Titles
Research Scientist
Deputy Director, Center for Neuroscience & Regeneration Research, Neurology
Appointments
Neurology
Research ScientistPrimary
Other Departments & Organizations
Education & Training
- Senior Researcher
- MetroHealth Medical Center (2007)
- Researcher PhD
- MetroHealth Medical Center (1998)
- Assistant Researcher
- UC Irvine (1996)
- Post Graduate Researcher
- UC Irvine (1994)
- Assistant Researcher
- University of Hawaii (1993)
- Junior Researcher
- University of Hawaii (1991)
- Post Graduate Researcher
- UC Irvine (1990)
- PhD
- University of California/Irvine (1989)
- BS
- Harvey Mudd College (1982)
Research
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Overview
Medical Research Interests
Biophysics; Electrophysiology; Neurophysiology; Neurosciences; Physiology
ORCID
0000-0002-7271-1165
Research at a Glance
Yale Co-Authors
Frequent collaborators of Mark Estacion's published research.
Publications Timeline
A big-picture view of Mark Estacion's research output by year.
Research Interests
Research topics Mark Estacion is interested in exploring.
Stephen Waxman, MD, PhD
Sulayman Dib-Hajj, PhD
Betsy Schulman, PhD
Peng Zhao, PhD
Jin Choi
Former YSMMohammad-Reza Ghovanloo, PhD
48Publications
2,730Citations
Electrophysiology
Publications
2026
Human-specific features of the cerebellum and ZP2-regulated synapse development
Kim S, Cherskov A, Sindhwani A, Choi S, Kim H, Li M, Zhang M, Mato-Blanco X, Liu Y, Micali N, Young D, Estacion M, Zhang Y, Ruiz-Jiménez J, Nadkarni A, Luria V, Sindhu S, Chatterjee I, Shibata A, Liang D, Cho H, Park S, Spajic A, Kovner R, Glavan M, Chen R, Risgaard R, Li X, Pochareddy S, Karger A, Huttner A, Morozov Y, Daadi E, Colantuoni C, Gobeske K, Ely J, Hof P, Daadi M, Sherwood C, Duque A, Ma S, Sousa A, Waxman S, Rakic P, Santpere G, Sanders S, Sestan N. Human-specific features of the cerebellum and ZP2-regulated synapse development. Cell 2026, 189: 1802-1819.e28. PMID: 41819103, DOI: 10.1016/j.cell.2026.02.014.Peer-Reviewed Original ResearchCitationsAltmetric
2025
High-throughput multiplex voltage-clamp/current-clamp evaluation of acutely isolated neurons
Ghovanloo M, Tyagi S, Zhao P, Kiziltug E, Estacion M, Effraim P, Dib-Hajj S, Waxman S. High-throughput multiplex voltage-clamp/current-clamp evaluation of acutely isolated neurons. Nature Protocols 2025, 21: 609-634. PMID: 40514421, PMCID: PMC13037423, DOI: 10.1038/s41596-025-01194-0.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCitationsAltmetric
2023
Kv7-specific activators hyperpolarize resting membrane potential and modulate human iPSC-derived sensory neuron excitability
Estacion M, Liu S, Cheng X, Dib-Hajj S, Waxman S. Kv7-specific activators hyperpolarize resting membrane potential and modulate human iPSC-derived sensory neuron excitability. Frontiers In Pharmacology 2023, 14: 1138556. PMID: 36923357, PMCID: PMC10008904, DOI: 10.3389/fphar.2023.1138556.Peer-Reviewed Original ResearchCitationsAltmetricHigh-throughput combined voltage-clamp/current-clamp analysis of freshly isolated neurons
Ghovanloo M, Tyagi S, Zhao P, Kiziltug E, Estacion M, Dib-Hajj S, Waxman S. High-throughput combined voltage-clamp/current-clamp analysis of freshly isolated neurons. Cell Reports Methods 2023, 3: 100385. PMID: 36814833, PMCID: PMC9939380, DOI: 10.1016/j.crmeth.2022.100385.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords
2022
Fibroblast growth factor homologous factor 2 attenuates excitability of DRG neurons
Effraim PR, Estacion M, Zhao P, Sosniak D, Waxman SG, Dib-Hajj SD. Fibroblast growth factor homologous factor 2 attenuates excitability of DRG neurons. Journal Of Neurophysiology 2022, 128: 1258-1266. PMID: 36222860, PMCID: PMC9909838, DOI: 10.1152/jn.00361.2022.Peer-Reviewed Original ResearchCitationsAltmetric
2020
Differential effect of lacosamide on Nav1.7 variants from responsive and non-responsive patients with small fibre neuropathy
Labau J, Estacion M, Tanaka BS, de Greef B, Hoeijmakers J, Geerts M, Gerrits MM, Smeets H, Faber CG, Merkies I, Lauria G, Dib-Hajj SD, Waxman SG. Differential effect of lacosamide on Nav1.7 variants from responsive and non-responsive patients with small fibre neuropathy. Brain 2020, 143: 771-782. PMID: 32011655, PMCID: PMC7089662, DOI: 10.1093/brain/awaa016.Peer-Reviewed Original ResearchCitationsAltmetricA 49-residue sequence motif in the C terminus of Nav1.9 regulates trafficking of the channel to the plasma membrane
Sizova D, Huang J, Akin E, Estacion M, Gomis-Perez C, Waxman S, Dib-Hajj S. A 49-residue sequence motif in the C terminus of Nav1.9 regulates trafficking of the channel to the plasma membrane. Journal Of Biological Chemistry 2020, 295: 1077-1090. DOI: 10.1016/s0021-9258(17)49917-0.Peer-Reviewed Original ResearchCitations
2018
Gain of Function NaV1.7 Mutations in Idiopathic Small Fiber Neuropathy
Faber C, Hoeijmakers J, Ahn H, Cheng X, Han C, Choi J, Estacion M, Lauria G, Vanhoutte E, Gerrits M, Dib-Hajj S, Drenth J, Waxman S, Merkies I. Gain of Function NaV1.7 Mutations in Idiopathic Small Fiber Neuropathy. 2018, 175-194. DOI: 10.7551/mitpress/10310.003.0022.Peer-Reviewed Original ResearchStructural Modelling and Mutant Cycle Analysis Predict Pharmacoresponsiveness of a NaV1.7 Mutant Channel
Yang Y, Dib-Hajj S, Zhang J, Zhang Y, Tyrrell L, Estacion M, Waxman S. Structural Modelling and Mutant Cycle Analysis Predict Pharmacoresponsiveness of a NaV1.7 Mutant Channel. 2018, 251-270. DOI: 10.7551/mitpress/10310.003.0029.Peer-Reviewed Original ResearchPharmacotherapy for Pain in a Family with Inherited Erythromelalgia Guided by Genomic Analysis and Functional Profiling
Geha P, Yang Y, Estacion M, Schulman B, Tokuno H, Apkarian A, Dib-Hajj S, Waxman S. Pharmacotherapy for Pain in a Family with Inherited Erythromelalgia Guided by Genomic Analysis and Functional Profiling. 2018, 275-288. DOI: 10.7551/mitpress/10310.003.0031.Peer-Reviewed Original Research
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