2022
The AIM2 inflammasome is activated in astrocytes during the late phase of EAE
Barclay WE, Aggarwal N, Deerhake ME, Inoue M, Nonaka T, Nozaki K, Luzum NA, Miao EA, Shinohara ML. The AIM2 inflammasome is activated in astrocytes during the late phase of EAE. JCI Insight 2022, 7: e155563. PMID: 35451371, PMCID: PMC9089781, DOI: 10.1172/jci.insight.155563.Peer-Reviewed Original ResearchConceptsExperimental autoimmune encephalomyelitisCentral nervous systemInflammasome activationInflammasome-mediated inflammationRole of inflammasomesApoptosis-associated speck-like proteinIL-1β releaseAIM2 inflammasome activationSpeck-like proteinAutoimmune encephalomyelitisEffector cytokinesAutoimmune conditionsIL-18Multiple sclerosisIL-1βDisease peakInflammatory responseSpinal cordMelanoma 2Mouse modelAnimal modelsReporter miceNervous systemMyeloid cellsAIM2 inflammasome
2020
Functional heterogeneity of alveolar macrophage population based on expression of CXCL2
Xu-Vanpala S, Deerhake ME, Wheaton JD, Parker ME, Juvvadi PR, MacIver N, Ciofani M, Shinohara ML. Functional heterogeneity of alveolar macrophage population based on expression of CXCL2. Science Immunology 2020, 5 PMID: 32769172, PMCID: PMC7717592, DOI: 10.1126/sciimmunol.aba7350.Peer-Reviewed Original ResearchConceptsPulmonary fungal infectionAlveolar macrophagesFungal infectionsAM subpopulationsPharmacological intervention targetPro-inflammatory moleculesLung-resident macrophagesAnti-inflammatory moleculesExpression of CXCL2Strong inflammatory responseAlveolar macrophage populationComplement component 1qDistinct metabolic profilesC1q expressionInterleukin-10Inflammatory responseSentinel cellsPhagocytic capacityMacrophage populationsCXCL2InfectionMetabolic profileIntervention targetsSubpopulationsAM population