2021
Single-Cell Transcriptional Heterogeneity of Neutrophils During Acute Pulmonary Cryptococcus neoformans Infection
Deerhake ME, Reyes EY, Xu-Vanpala S, Shinohara ML. Single-Cell Transcriptional Heterogeneity of Neutrophils During Acute Pulmonary Cryptococcus neoformans Infection. Frontiers In Immunology 2021, 12: 670574. PMID: 33995406, PMCID: PMC8116703, DOI: 10.3389/fimmu.2021.670574.Peer-Reviewed Original ResearchConceptsPulmonary Cryptococcus neoformans infectionDistinct neutrophil subsetsCryptococcus neoformans infectionRole of neutrophilsLigand-receptor analysisCytokine gene expressionFirst-line defensePulmonary cryptococcosisNeoformans infectionDendritic cellsNeutrophil subsetsNeutrophil heterogeneityNeutrophil functionImmune cellsCell transcriptional heterogeneityAlveolar macrophagesNeutrophilsFungal infectionsCryptococcus neoformansInfectionSingle-cell transcriptional analysisGene expressionGenerate ROSOxidative stress signatureTranscriptional heterogeneity
2020
Functional heterogeneity of alveolar macrophage population based on expression of CXCL2
Xu-Vanpala S, Deerhake ME, Wheaton JD, Parker ME, Juvvadi PR, MacIver N, Ciofani M, Shinohara ML. Functional heterogeneity of alveolar macrophage population based on expression of CXCL2. Science Immunology 2020, 5 PMID: 32769172, PMCID: PMC7717592, DOI: 10.1126/sciimmunol.aba7350.Peer-Reviewed Original ResearchConceptsPulmonary fungal infectionAlveolar macrophagesFungal infectionsAM subpopulationsPharmacological intervention targetPro-inflammatory moleculesLung-resident macrophagesAnti-inflammatory moleculesExpression of CXCL2Strong inflammatory responseAlveolar macrophage populationComplement component 1qDistinct metabolic profilesC1q expressionInterleukin-10Inflammatory responseSentinel cellsPhagocytic capacityMacrophage populationsCXCL2InfectionMetabolic profileIntervention targetsSubpopulationsAM population