2024
Opportunities for Improving Biopsy and Non–Biopsy-Based Diagnosis of Celiac Disease
Robert M, Ciacci C, Lebwohl B. Opportunities for Improving Biopsy and Non–Biopsy-Based Diagnosis of Celiac Disease. Gastroenterology 2024, 167: 79-89. PMID: 38302007, DOI: 10.1053/j.gastro.2024.01.031.Peer-Reviewed Original Research
2023
Clinical Data Do Not Reliably Predict Duodenal Histology at Follow-up in Celiac Disease
Patel N, Leffler D, Al-Toma A, Mulder C, Elli L, Gan G, Patil P, Atsawarungruangkit A, Kuijpers K, Del Gobbo A, Goldsmith J, Hintze Z, Pacheco M, Vieth M, Melcher B, Salomao M, Pai R, Hart J, Olivas A, Naini B, Meyerson C, Choi W, Kakar S, Westerhoff M, Cheng J, Gopal P, Hammer S, Prats M, Bronner M, Robert M. Clinical Data Do Not Reliably Predict Duodenal Histology at Follow-up in Celiac Disease. The American Journal Of Surgical Pathology 2023, 48: 212-220. PMID: 37994653, DOI: 10.1097/pas.0000000000002150.Peer-Reviewed Original ResearchIntraepithelial lymphocytesCeliac diseaseClinical dataMarsh scoreMucosal recoveryVillous bluntingDuodenal biopsiesMucosal injuryDiet adherenceGluten-free diet adherenceComplete histologic remissionPersistent mucosal injuryMinority of patientsCeliac disease patientsDuodenal histologyHistologic remissionPathologists' awarenessMucosal statusMucosal healingGastrointestinal pathologistsDisease patientsFollow-upPatient managementEligibility criteriaPatientsStandardizing Randomized Controlled Trials in Celiac Disease: An International Multidisciplinary Appropriateness Study
Lebwohl B, Ma C, Lagana S, Pai R, Baker K, Zayadi A, Hogan M, Bouma G, Cellier C, Goldsmith J, Lundin K, Pinto-Sanchez M, Robert M, Rubio-Tapia A, Sanders D, Schaeffer D, Semrad C, Silvester J, Verdú E, Verma R, Wu T, Feagan B, Crowley E, Jairath V, Murray J. Standardizing Randomized Controlled Trials in Celiac Disease: An International Multidisciplinary Appropriateness Study. Gastroenterology 2023, 166: 88-102. PMID: 37704112, DOI: 10.1053/j.gastro.2023.08.051.Peer-Reviewed Original ResearchConceptsRandomized controlled trialsSecondary patient-reported outcome measuresOutcome measuresRandomized controlled trial designPatient-reported outcome measuresControlled trialsGluten challengeStandard Randomized Controlled TrialPatient-reported outcomesGluten-free dietReversal of histological changesMethods studyCeliac diseaseEligibility criteriaHistological end pointsPrevention of relapseEffective pharmacological optionsAppropriate studiesTrial outcomesExclusion criteriaClinical trial designTrial designTreatment of celiac diseasePediatric patientsPharmacological options
2020
Frontiers in Celiac Disease
Patel N, Robert ME. Frontiers in Celiac Disease. The American Journal Of Surgical Pathology 2020, 46: e43-e54. PMID: 33739793, DOI: 10.1097/pas.0000000000001639.Peer-Reviewed Original ResearchConceptsCeliac diseaseType II refractory celiac diseaseMonoclonal T-cell populationChildhood viral infectionsDuodenal mucosal histologyImportant autoimmune diseasesRefractory celiac diseaseCommon autoimmune disorderT cell populationsCeliac disease patientsCeliac disease pathogenesisEvaluation of responseCeliac disease manifestationsGluten toleranceDietary glutenGluten exposureMechanisms of diseaseAutoimmune conditionsHLA-DQ2Mucosal histologySymptomatic diseaseInflammatory cascadeInitial diagnosisPatient's symptomsAutoimmune disordersImmune Checkpoint Inhibitor–Induced Upper Gastrointestinal Tract Inflammation Shows Morphologic Similarities to, but Is Immunologically Distinct From, Helicobacter pylori Gastritis and Celiac Disease
Irshaid L, Robert ME, Zhang X. Immune Checkpoint Inhibitor–Induced Upper Gastrointestinal Tract Inflammation Shows Morphologic Similarities to, but Is Immunologically Distinct From, Helicobacter pylori Gastritis and Celiac Disease. Archives Of Pathology & Laboratory Medicine 2020, 145: 191-200. PMID: 33501492, DOI: 10.5858/arpa.2019-0700-oa.Peer-Reviewed Original ResearchConceptsHelicobacter pylori gastritisUpper gastrointestinal tractCeliac diseasePylori gastritisCPI therapyCD8 ratioDuodenal biopsiesInflammatory changesLymphoid aggregatesGastrointestinal tractAnti-programmed death receptor-1/Anti-cytotoxic T-lymphocyteDeath receptor-1/Immune checkpoint inhibitor therapyImmune-related adverse eventsDeath ligand 1 antibodyColonic mucosal changesGastrointestinal tract inflammationLamina propria CD3Lamina propria inflammationUpper gastrointestinal biopsiesUpper gastrointestinal injuryCheckpoint inhibitor therapyH pylori gastritisCD8 T cells
2019
Mo1984 – Symptom Profiles, Gluten Free Diet Adherence, and Laboratory Data Do Not Reliably Predict Duodenal Mucosal Healing in Follow Up Biopsies from Patients with Celiac Disease in a Multinational Pathology Based Cohort
Patel N, Atsawarungruangkit A, Leffler D, Hart J, Olivas A, Vieth M, Melcher B, Al-toma A, Mulder C, Salomao M, Pai R, Bronner M, Prats M, Naini B, Meyerson C, Elli L, del Gobbo A, Kakar S, Choi W, Gopal P, Westerhoff M, Cheng J, Robert M. Mo1984 – Symptom Profiles, Gluten Free Diet Adherence, and Laboratory Data Do Not Reliably Predict Duodenal Mucosal Healing in Follow Up Biopsies from Patients with Celiac Disease in a Multinational Pathology Based Cohort. Gastroenterology 2019, 156: s-911. DOI: 10.1016/s0016-5085(19)39247-9.Peer-Reviewed Original Research600 – Concordance of Bulb and Distal Duodenal Findings in Celiac Disease Follow Up Biopsies: Limited Clinical Relevance of Bulb Only Persistent Mucosal Injury
Patel N, Atsawarungruangkit A, Leffler D, Hart J, Olivas A, Vieth M, Melcher B, Al-toma A, Mulder C, Pai R, Salomao M, Bronner M, Prats M, Naini B, Meyerson C, Elli L, del Gobbo A, Kakar S, Choi W, Gopal P, Westerhoff M, Cheng J, Robert M. 600 – Concordance of Bulb and Distal Duodenal Findings in Celiac Disease Follow Up Biopsies: Limited Clinical Relevance of Bulb Only Persistent Mucosal Injury. Gastroenterology 2019, 156: s-119-s-120. DOI: 10.1016/s0016-5085(19)37091-x.Peer-Reviewed Original ResearchClinical Insignficance of Monoclonal T-Cell Populations and Duodenal Intraepithelial T-Cell Phenotypes in Celiac and Nonceliac Patients
Celli R, Hui P, Triscott H, Bogardus S, Gibson J, Hwang M, Robert ME. Clinical Insignficance of Monoclonal T-Cell Populations and Duodenal Intraepithelial T-Cell Phenotypes in Celiac and Nonceliac Patients. The American Journal Of Surgical Pathology 2019, 43: 151-160. PMID: 30334829, DOI: 10.1097/pas.0000000000001172.Peer-Reviewed Original ResearchConceptsRefractory celiac diseaseT cell populationsMonoclonal T-cell populationRCD IRCD IICeliac diseasePersistent symptomsCD patientsIntraepithelial lymphocytesType II refractory celiac diseaseCD8-positive intraepithelial lymphocytesClonal T-cell populationsT-cell receptor gene rearrangementsAbnormal intraepithelial lymphocytesT-cell phenotypeReceptor gene rearrangementsParaffin-embedded biopsiesParaffin-embedded tissuesCD8 stainingLymphocyte phenotypingNonceliac patientsVillous bluntingDuodenal biopsiesRare conditionSpecialized centers
2018
Statement on Best Practices in the Use of Pathology as a Diagnostic Tool for Celiac Disease
Robert ME, Crowe SE, Burgart L, Yantiss RK, Lebwohl B, Greenson JK, Guandalini S, Murray JA. Statement on Best Practices in the Use of Pathology as a Diagnostic Tool for Celiac Disease. The American Journal Of Surgical Pathology 2018, 42: e44-e58. PMID: 29923907, DOI: 10.1097/pas.0000000000001107.Peer-Reviewed Original ResearchConceptsDuodenal mucosal biopsiesCeliac diseaseMucosal biopsiesPossible celiac diseaseUse of pathologySpecific serological testsUse of endoscopyEndoscopic findingsIntraepithelial lymphocytesPathologic assessmentPathologic findingsVillous architectureNorth American AssociationPathology formsBiopsy interpretationBiopsySerological testsTissue samplingDiseasePatientsDiagnostic toolDiagnosisAmerican AssociationPathologistsCritical appraisal
2000
The Histologic Spectrum and Clinical Outcome of Refractory and Unclassified Sprue
Robert M, Ament M, Weinstein W. The Histologic Spectrum and Clinical Outcome of Refractory and Unclassified Sprue. The American Journal Of Surgical Pathology 2000, 24: 676-687. PMID: 10800986, DOI: 10.1097/00000478-200005000-00006.Peer-Reviewed Original ResearchConceptsSmall bowel biopsyBowel biopsyCollagenous sprueUnclassified sprueRefractory patientsCeliac diseaseNormal duodenal biopsiesResidual mucosal abnormalityResponsive celiac diseaseSetting of malabsorptionGluten-free dietTotal parenteral nutritionGroup of patientsLong-term followB-cell lymphomaSubtle histologic changesMucosal thinningPersistent malabsorptionDuodenal biopsiesParenteral nutritionRefractory courseRefractory diseaseNonspecific findingsClinical outcomesChronic inflammation