2021
A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice
Mao T, Israelow B, Lucas C, Vogels CBF, Gomez-Calvo ML, Fedorova O, Breban MI, Menasche BL, Dong H, Linehan M, Alpert T, Anderson F, Earnest R, Fauver J, Kalinich C, Munyenyembe K, Ott I, Petrone M, Rothman J, Watkins A, Wilen C, Landry M, Grubaugh N, Pyle A, Iwasaki A. A stem-loop RNA RIG-I agonist protects against acute and chronic SARS-CoV-2 infection in mice. Journal Of Experimental Medicine 2021, 219: e20211818. PMID: 34757384, PMCID: PMC8590200, DOI: 10.1084/jem.20211818.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntiviral AgentsCOVID-19COVID-19 Drug TreatmentDisease Models, AnimalImmunity, InnateInterferon Type IMiceMice, Inbred BALB CRNASARS-CoV-2ConceptsSARS-CoV-2 infectionChronic SARS-CoV-2 infectionVariants of concernLethal SARS-CoV-2 infectionPost-infection therapyLower respiratory tractPost-exposure treatmentType I interferonSARS-CoV-2Effective medical countermeasuresAdaptive immune systemBroad-spectrum antiviralsContext of infectionSingle doseRespiratory tractViral controlImmunodeficient miceSevere diseaseMouse modelI interferonViral infectionImmune systemInnate immunityDisease preventionConsiderable efficacy
1984
Genital Herpes: Pathogenesis and Chemotherapy in the Guinea Pig Model
Hsiung G, Mayo D, Lucia H, Landry M. Genital Herpes: Pathogenesis and Chemotherapy in the Guinea Pig Model. Clinical Infectious Diseases 1984, 6: 33-50. PMID: 6324317, DOI: 10.1093/clinids/6.1.33.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornDisease Models, AnimalFemaleGuinea PigsHerpes GenitalisMaleSimplexvirusConceptsGuinea pig modelGenital herpesAnimal modelsPig modelHuman infectionsNatural historyCommon venereal diseaseRecurrent genital diseaseEffect of immunosuppressionHerpes simplex virusIndividual host responsesNeonatal herpesHerpes infectionPathologic featuresGenital diseaseSimplex virusAntiviral drugsLatent infectionNervous systemHost responseHerpesLow dosesGuinea pigsInfectionDisease