2019
Novel radioligands for imaging sigma-1 receptor in brain using positron emission tomography (PET)
Lan Y, Bai P, Chen Z, Neelamegam R, Placzek M, Wang H, Fiedler S, Yang J, Yuan G, Qu X, Schmidt H, Song J, Normandin M, Ran C, Wang C. Novel radioligands for imaging sigma-1 receptor in brain using positron emission tomography (PET). Acta Pharmaceutica Sinica B 2019, 9: 1204-1215. PMID: 31867166, PMCID: PMC6900558, DOI: 10.1016/j.apsb.2019.07.002.Peer-Reviewed Original ResearchPositron emission tomographySigma-1 receptorCentral nervous systemPET/CT imagingEmission tomographyOrgans of micePositron emission tomography tracersNeuropsychiatric disordersNon-invasive quantificationBrain regionsNoninvasive toolSigma-1RadioligandDisease pathophysiologyNervous systemNovel radioligandMiceMouse brainPathological conditionsBrainReceptorsTomographyIntracellular proteinsTarget validationPET/CT
2014
Initial in vivo PET imaging of 5-HT1A receptors with 3-[(18)F]mefway.
Wooten DW, Hillmer AT, Murali D, Barnhart TE, Thio JP, Bajwa AK, Bonab AA, Normandin MD, Schneider ML, Mukherjee J, Christian BT. Initial in vivo PET imaging of 5-HT1A receptors with 3-[(18)F]mefway. American Journal Of Nuclear Medicine And Molecular Imaging 2014, 4: 483-9. PMID: 25143866, PMCID: PMC4138142.Peer-Reviewed Original ResearchCaudal anterior cingulate gyrusMesial temporal lobePET radiotracersPET imagingAnterior cingulate gyrusDynamic PET scansVivo PET imagingMale rhesus macaquesBolus injectionCingulate gyrusPET uptakeTemporal lobePET scansLower BPNDLow affinityVivo behaviorCerebellumRhesus macaquesReceptorsSufficient uptakeReference regionSpecific bindingMinutesRadiotracerShorter scan time