2024
PET mapping of receptor occupancy using joint direct parametric reconstruction
Marin T, Belov V, Chemli Y, Ouyang J, Najmaoui Y, Fakhri G, Duvvuri S, Iredale P, Guehl N, Normandin M, Petibon Y. PET mapping of receptor occupancy using joint direct parametric reconstruction. IEEE Transactions On Biomedical Engineering 2024, PP: 1-15. PMID: 39446540, DOI: 10.1109/tbme.2024.3486191.Peer-Reviewed Original ResearchCentral nervous systemReceptor occupancyLow-binding regionsPET scansSimulation resultsPreclinical in vivo experimentsDynamic PET scansPairs of baselineEstimation of receptor occupancyEstimation frameworkPET neuroimagingReconstruction frameworkModulating drugsTime activity curvesParametric reconstructionDevelopment of drugs
2022
Human biodistribution and radiation dosimetry of the demyelination tracer [18F]3F4AP
Brugarolas P, Wilks M, Noel J, Kaiser J, Vesper D, Ramos-Torres K, Guehl N, Macdonald-Soccorso M, Sun Y, Rice P, Yokell D, Lim R, Normandin M, El Fakhri G. Human biodistribution and radiation dosimetry of the demyelination tracer [18F]3F4AP. European Journal Of Nuclear Medicine And Molecular Imaging 2022, 50: 344-351. PMID: 36197499, PMCID: PMC9816249, DOI: 10.1007/s00259-022-05980-w.Peer-Reviewed Original ResearchConceptsRadiation dosimetryTime-activity curvesAdverse eventsEffective doseMultiple bed positionsComprehensive metabolic panelNonhuman primatesHealthy human volunteersNo adverse eventsDynamic PET scansVoltage-gated potassiumAnimal models of neurological diseasesNonhuman primate studiesModels of neurological diseasesHuman biodistributionAverage effective doseMetabolic panelDosimetryOLINDA softwareHealthy volunteersUrinary bladderPET scansDemyelinating lesionsBed positionAnimal models
2014
Initial in vivo PET imaging of 5-HT1A receptors with 3-[(18)F]mefway.
Wooten DW, Hillmer AT, Murali D, Barnhart TE, Thio JP, Bajwa AK, Bonab AA, Normandin MD, Schneider ML, Mukherjee J, Christian BT. Initial in vivo PET imaging of 5-HT1A receptors with 3-[(18)F]mefway. American Journal Of Nuclear Medicine And Molecular Imaging 2014, 4: 483-9. PMID: 25143866, PMCID: PMC4138142.Peer-Reviewed Original ResearchCaudal anterior cingulate gyrusMesial temporal lobePET radiotracersPET imagingAnterior cingulate gyrusDynamic PET scansVivo PET imagingMale rhesus macaquesBolus injectionCingulate gyrusPET uptakeTemporal lobePET scansLower BPNDLow affinityVivo behaviorCerebellumRhesus macaquesReceptorsSufficient uptakeReference regionSpecific bindingMinutesRadiotracerShorter scan time