2021
Synthesis and Characterization of [18F]JNJ-46356479 as the First 18F-Labeled PET Imaging Ligand for Metabotropic Glutamate Receptor 2
Yuan G, Guehl N, Zheng B, Qu X, Moon S, Dhaynaut M, Shoup T, Afshar S, Kang H, Zhang Z, El Fakhri G, Normandin M, Brownell A. Synthesis and Characterization of [18F]JNJ-46356479 as the First 18F-Labeled PET Imaging Ligand for Metabotropic Glutamate Receptor 2. Molecular Imaging And Biology 2021, 23: 527-536. PMID: 33559035, PMCID: PMC8277681, DOI: 10.1007/s11307-021-01586-0.Peer-Reviewed Original ResearchConceptsNon-human primatesIn vivo PET imaging studiesNucleus accumbensGlutamate receptor 2PET imaging ligandsImaging ligandsParietal cortexBrain regionsPET imaging studiesPET radioligandIn vivo PET imaging experimentsVolume of distributionMGluR2C57BL/6 J micePET imaging experimentsPET studiesBrainSprague-Dawley ratsAlzheimer's diseaseBrain permeabilityPre-treatment studyImaging studiesDisordersRat studiesReversible kinetics
2019
[18F]-AV-1451 binding profile in chronic traumatic encephalopathy: a postmortem case series
Marquié M, Agüero C, Amaral A, Villarejo-Galende A, Ramanan P, Chong M, Sáez-Calveras N, Bennett R, Verwer E, Kim S, Dhaynaut M, Alvarez V, Johnson K, McKee A, Frosch M, Gómez-Isla T. [18F]-AV-1451 binding profile in chronic traumatic encephalopathy: a postmortem case series. Acta Neuropathologica Communications 2019, 7: 164. PMID: 31661038, PMCID: PMC6816221, DOI: 10.1186/s40478-019-0808-1.Peer-Reviewed Original ResearchConceptsTau aggregationPositron emission tomographyTau lesionsPresence of tau aggregatesInferior parietal cortexSuperior temporal cortexPaired helical filamentsTau seeding activityHyperphosphorylated tau speciesDetection of tau aggregatesTraumatic encephalopathyPostmortem brain tissue samplesCorticobasal degenerationProgressive supranuclear palsyBinding profilesTau-containing lesionsRepetitive head traumaDifferential binding affinityFrontal cortexTemporal cortexParietal cortexTau conformationTau speciesBinding affinityOccipital cortex