2022
Endothelial Cell TGF-β (Transforming Growth Factor-Beta) Signaling Regulates Venous Adaptive Remodeling to Improve Arteriovenous Fistula Patency
Taniguchi R, Ohashi Y, Lee JS, Hu H, Gonzalez L, Zhang W, Langford J, Matsubara Y, Yatsula B, Tellides G, Fahmy TM, Hoshina K, Dardik A. Endothelial Cell TGF-β (Transforming Growth Factor-Beta) Signaling Regulates Venous Adaptive Remodeling to Improve Arteriovenous Fistula Patency. Arteriosclerosis Thrombosis And Vascular Biology 2022, 42: 868-883. PMID: 35510552, PMCID: PMC9233042, DOI: 10.1161/atvbaha.122.317676.Peer-Reviewed Original ResearchConceptsArteriovenous fistulaSMC proliferationAVF patencyCollagen densityMouse aortocaval fistula modelTGF-β receptor IArteriovenous fistula patencyAortocaval fistula modelInhibition of TGFPredetermined time pointsTGF-β inhibitionTGF-β signalingTGF-β receptorDisruption of TGFFistula patencyAVF failureWall thicknessVascular accessVenous remodelingSuccessful hemodialysisDoppler ultrasoundFistula modelReceptor IPatencyTGF
2020
Activation of EphrinB2 Signaling Promotes Adaptive Venous Remodeling in Murine Arteriovenous Fistulae
Wang T, Liu J, Liu H, Lee SR, Gonzalez L, Gorecka J, Shu C, Dardik A. Activation of EphrinB2 Signaling Promotes Adaptive Venous Remodeling in Murine Arteriovenous Fistulae. Journal Of Surgical Research 2020, 262: 224-239. PMID: 33039109, PMCID: PMC8024410, DOI: 10.1016/j.jss.2020.08.071.Peer-Reviewed Original ResearchConceptsEndothelial nitric oxide synthasePhosphorylation of EphrinB2AVF maturationNitric oxide synthaseArteriovenous fistulaVenous remodelingEphB4-FcOxide synthaseEndothelial cell functionEndothelial cell tube formationExtracellular signal-regulated kinases 1/2Murine arteriovenous fistulaSignal-regulated kinases 1/2Cell tube formationAortocaval fistulaHuman endothelial cellsVascular accessExpression of ephrinB2Endothelial cell culture mediumDay 7FistulaEndothelial cellsArterial identityCell functionTube formation