Activation of EphrinB2 Signaling Promotes Adaptive Venous Remodeling in Murine Arteriovenous Fistulae
Wang T, Liu J, Liu H, Lee SR, Gonzalez L, Gorecka J, Shu C, Dardik A. Activation of EphrinB2 Signaling Promotes Adaptive Venous Remodeling in Murine Arteriovenous Fistulae. Journal Of Surgical Research 2020, 262: 224-239. PMID: 33039109, PMCID: PMC8024410, DOI: 10.1016/j.jss.2020.08.071.Peer-Reviewed Original ResearchConceptsEndothelial nitric oxide synthasePhosphorylation of EphrinB2AVF maturationNitric oxide synthaseArteriovenous fistulaVenous remodelingEphB4-FcOxide synthaseEndothelial cell functionEndothelial cell tube formationExtracellular signal-regulated kinases 1/2Murine arteriovenous fistulaSignal-regulated kinases 1/2Cell tube formationAortocaval fistulaHuman endothelial cellsVascular accessExpression of ephrinB2Endothelial cell culture mediumDay 7FistulaEndothelial cellsArterial identityCell functionTube formation