Inherited Retinal Degenerations and Non-Neovascular Age-Related Macular Degeneration: Progress and Unmet Needs
Duncan J, Bowman A, Laster A, Gelfman C, Birch D, Boye S, Daiger S, del Priore L, Zack D, Handa J, Board T. Inherited Retinal Degenerations and Non-Neovascular Age-Related Macular Degeneration: Progress and Unmet Needs. Translational Vision Science & Technology 2024, 13: 28. PMID: 39688851, PMCID: PMC11654773, DOI: 10.1167/tvst.13.12.28.Peer-Reviewed Original ResearchTo Treat or Not to Treat Geographic Atrophy – That is the Question
Del Priore L. To Treat or Not to Treat Geographic Atrophy – That is the Question. Ophthalmology Retina 2024, 8: 207-209. PMID: 38448115, DOI: 10.1016/j.oret.2023.12.008.Peer-Reviewed Original ResearchGeographic AtrophyHumansPhenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic health
Zekavat S, Jorshery S, Rauscher F, Horn K, Sekimitsu S, Koyama S, Nguyen T, Costanzo M, Jang D, Burtt N, Kühnapfel A, Shweikh Y, Ye Y, Raghu V, Zhao H, Ghassemi M, Elze T, Segrè A, Wiggs J, Del Priore L, Scholz M, Wang J, Natarajan P, Zebardast N. Phenome- and genome-wide analyses of retinal optical coherence tomography images identify links between ocular and systemic health. Science Translational Medicine 2024, 16: eadg4517. PMID: 38266105, DOI: 10.1126/scitranslmed.adg4517.Peer-Reviewed Original ResearchConceptsGenome-wide association studiesRetinal layer thicknessPhotoreceptor segmentsOptical coherence tomographyRetinal layersUK Biobank participantsLIFE-Adult-StudyInherited genetic lociGenome-wide associationGanglion cell complex layerRetinal optical coherence tomography imagesRetinal nerve fiber layerAge-related macular degenerationBiobank participantsEye careNerve fiber layerOptical coherence tomography imagesIncident mortalityMacular OCT imagesLIFE-AdultIndependent associationsAssociation studiesSystemic healthGenetic associationGenome-wide analysis