2024
Impact of a multicomponent strategy including decentralized molecular testing for tuberculosis on mortality: planned analysis of a cluster-randomized trial in Uganda
Katamba A, Mochizuki T, Nalugwa T, Nantale M, Oyuku D, Nabwire S, Babirye D, Musinguzi J, Nakawesa A, Nekesa I, Turyahabwe S, Joloba M, Dowdy D, Moore D, Davis J, Shete P, Adams K, Reza T, Fielding K, Cattamanchi A. Impact of a multicomponent strategy including decentralized molecular testing for tuberculosis on mortality: planned analysis of a cluster-randomized trial in Uganda. EClinicalMedicine 2024, 78: 102953. PMCID: PMC11629260, DOI: 10.1016/j.eclinm.2024.102953.Peer-Reviewed Original ResearchCommunity health centersCluster randomized trialHealth centersPragmatic cluster randomized trialMulticomponent strategiesSix-month mortality riskSecondary outcomesPan African Clinical Trials RegistryCluster-level analysisPatient-level covariatesAll-cause mortalityClinical Trials RegistryIntervention armSub-group analysisTB careMortality risk analysisRoutine careVital statusTrial armsMagnitude of effectPresumptive TBRate ratiosProximal outcomesTrial participantsUS National Institutes
2022
Assessing the quality of tuberculosis care using routine surveillance data: a process evaluation employing the Zero TB Indicator Framework in Mongolia
Saranjav A, Parisi C, Zhou X, Dorjnamjil K, Samdan T, Erdenebaatar S, Chuluun A, Dalkh T, Ganbaatar G, Brooks MB, Spiegelman D, Ganmaa D, Davis JL. Assessing the quality of tuberculosis care using routine surveillance data: a process evaluation employing the Zero TB Indicator Framework in Mongolia. BMJ Open 2022, 12: e061229. PMID: 35973702, PMCID: PMC9386240, DOI: 10.1136/bmjopen-2022-061229.Peer-Reviewed Original ResearchConceptsPrimary health centersTB preventive therapyRoutine surveillance dataHealth centersHousehold contactsCohort studyPreventive therapyTB careTB dispensariesRetrospective cross-sectional cohort studyCross-sectional cohort studySurveillance dataActive TB treatmentGuideline-adherent careHealth system predictorsQuality of tuberculosisOdds of patientsHealth system factorsQuality improvement interventionsLow-quality careCare cascadeTB screeningTB treatmentTuberculosis careIndex patients
2021
Multicomponent Strategy with Decentralized Molecular Testing for Tuberculosis
Cattamanchi A, Reza T, Nalugwa T, Adams K, Nantale M, Oyuku D, Nabwire S, Babirye D, Turyahabwe S, Tucker A, Sohn H, Ferguson O, Thompson R, Shete P, Handley M, Ackerman S, Joloba M, Moore D, Davis J, Dowdy D, Fielding K, Katamba A. Multicomponent Strategy with Decentralized Molecular Testing for Tuberculosis. New England Journal Of Medicine 2021, 385: 2441-2450. PMID: 34936740, PMCID: PMC9212879, DOI: 10.1056/nejmoa2105470.Peer-Reviewed Original ResearchConceptsSame-day treatmentSame-day diagnosisHealth centersMolecular testingTuberculosis testingHuman immunodeficiency virus (HIV) infectionDiagnostic strategiesImmunodeficiency virus infectionCommunity health centersCluster-randomized trialTreatment of tuberculosisSecondary outcomesMore patientsPrimary outcomePrompt diagnosisRoutine careEligible adultsIntervention groupIntervention periodHigh burdenVirus infectionIntervention centersControl groupPatientsTuberculosis