2007
Absence of Significant Interactive Effects of High‐Dose d‐Cycloserine and Ethanol in Healthy Human Subjects: Preliminary Insights Into Ethanol Actions at the GlycineB Site of NMDA Glutamate Receptors
Trevisan L, Petrakis IL, Pittman B, Gueorguieva R, D’Souza D, Perry E, Limoncelli D, Krystal JH. Absence of Significant Interactive Effects of High‐Dose d‐Cycloserine and Ethanol in Healthy Human Subjects: Preliminary Insights Into Ethanol Actions at the GlycineB Site of NMDA Glutamate Receptors. Alcohol Clinical And Experimental Research 2007, 32: 36-42. PMID: 18028532, DOI: 10.1111/j.1530-0277.2007.00543.x.Peer-Reviewed Original ResearchConceptsCo-agonist siteHealthy human subjectsEthanol administrationD-cycloserineHigh-dose d-cycloserineAlcohol levelsReceptor functionPlacebo 4 hoursDouble-blind conditionsNMDA receptor functionNMDA glutamate receptorsMild sedative effectDoses of ethanolGlutamate receptor functionBreath alcohol levelsHuman subjectsVerbal fluencyGlycineB siteGroups of subjectsEthanol antagonismCombination of ethanolSedative effectsNMDA receptorsClinical significanceGlutamate receptors
1995
Biochemical actions of chronic ethanol exposure in the mesolimbic dopamine system
Ortiz J, Fitzgerald L, Charlton M, Lane S, Trevisan L, Guitart X, Shoemaker W, Duman R, Nestler E. Biochemical actions of chronic ethanol exposure in the mesolimbic dopamine system. Synapse 1995, 21: 289-298. PMID: 8869159, DOI: 10.1002/syn.890210403.Peer-Reviewed Original ResearchConceptsVentral tegmental areaChronic ethanol exposure resultsMesolimbic dopamine systemChronic ethanol treatmentEthanol exposure resultsAction of ethanolDopamine systemEthanol exposureNucleus accumbensGlutamate receptorsProtein immunoreactivityTyrosine hydroxylaseNeural pathwaysGlial fibrillary acidic protein immunoreactivityEthanol treatmentLong-term ethanol exposureNigrostriatal dopamine systemChronic ethanol exposureExposure resultsNMDA glutamate receptorsTyrosine hydroxylase expressionAMPA glutamate receptorsGABAA receptor complexLevels of immunoreactivityNeurofilament protein immunoreactivity