2008
Endoscopic Therapy for Bleeding Ulcers: An Evidence-Based Approach Based on Meta-Analyses of Randomized Controlled Trials
Laine L, McQuaid KR. Endoscopic Therapy for Bleeding Ulcers: An Evidence-Based Approach Based on Meta-Analyses of Randomized Controlled Trials. Clinical Gastroenterology And Hepatology 2008, 7: 33-47. PMID: 18986845, DOI: 10.1016/j.cgh.2008.08.016.Peer-Reviewed Original ResearchConceptsEndoscopic therapyProton pump inhibitorsActive bleedingVisible vesselPump inhibitorsIntravenous proton pump inhibitorsAppropriate endoscopic treatmentNonbleeding visible vesselPrimary end pointSecond-look endoscopyEndoscopic hemostatic therapyRandomized Controlled TrialsEvidence-based approachPlacebo/Further bleedingHemostatic therapyInjection therapyControlled TrialsEndoscopic treatmentRandomized trialsBleeding ulcersSclerosant therapyReceptor antagonistBibliographic database searchBleeding
2006
Systematic Review and Meta-analysis of Adverse Events of Low-dose Aspirin and Clopidogrel in Randomized Controlled Trials
McQuaid KR, Laine L. Systematic Review and Meta-analysis of Adverse Events of Low-dose Aspirin and Clopidogrel in Randomized Controlled Trials. The American Journal Of Medicine 2006, 119: 624-638. PMID: 16887404, DOI: 10.1016/j.amjmed.2005.10.039.Peer-Reviewed Original ResearchConceptsLow-dose aspirinAspirin/clopidogrelMajor GI bleedingMajor bleedingGI bleedingAdverse eventsIntracranial bleedingRelative riskSystematic reviewMajor bleeding episodesMajor gastrointestinal bleedingRelevant adverse eventsRisk of GIAbsolute risk increaseRandomized Controlled TrialsDay aspirinMajor GIBleeding episodesCardiovascular prophylaxisGastrointestinal bleedingAntiplatelet agentsControlled TrialsWeighted incidenceAbsolute riskClopidogrel
2005
Nonsteroidal Anti-Inflammatory Drugs and Hepatic Toxicity: A Systematic Review of Randomized Controlled Trials in Arthritis Patients
Rostom A, Goldkind L, Laine L. Nonsteroidal Anti-Inflammatory Drugs and Hepatic Toxicity: A Systematic Review of Randomized Controlled Trials in Arthritis Patients. Clinical Gastroenterology And Hepatology 2005, 3: 489-498. PMID: 15880319, DOI: 10.1016/s1542-3565(04)00777-3.Peer-Reviewed Original ResearchConceptsLiver-related deathLiver-related hospitalizationsSerious adverse eventsAnti-inflammatory drugsAminotransferase elevationAdverse eventsSide effectsNonsteroidal anti-inflammatory drugsTrials of diclofenacHepatic side effectsProportion of patientsClinical side effectsRandomized Controlled TrialsBibliographic databases MEDLINEHigh rateArthritis patientsControlled TrialsRheumatoid arthritisHepatic toxicityInclusion criteriaDatabases MEDLINENSAIDsDrug AdministrationSystematic reviewToxicity outcomes